Molecular basis of bilirubin UDP-glucuronosyltransferase induction in spontaneously diabetic rats, acetone-treated rats and starved rats
The co-ordinated induction of several hepatic drug-metabolizing enzymes is a common feature in the regulation of drug biotransformation under normal and pathological conditions. In the present study the activity and expression of bilirubin UDP-glucuronosyltransferase (UGT1A1) were investigated in li...
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| Veröffentlicht in: | Biochemical journal 1998-12, Vol.336 ( Pt 3) (3), p.587-592 |
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| container_title | Biochemical journal |
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| creator | Braun, L Coffey, M J Puskás, F Kardon, T Nagy, G Conley, A A Burchell, B Mandl, J |
| description | The co-ordinated induction of several hepatic drug-metabolizing enzymes is a common feature in the regulation of drug biotransformation under normal and pathological conditions. In the present study the activity and expression of bilirubin UDP-glucuronosyltransferase (UGT1A1) were investigated in livers of BioBreeding/Worcester diabetic, fasted and acetone-treated rats. Bilirubin glucuronidation was stimulated by all three treatments; this was correlated with an increase in the UGT1A1 protein concentration in hepatic microsomes. Transcriptional induction of UGT1A1 was also observed in diabetes and starvation but not with acetone treatment, which apparently caused translational stabilization of the enzyme protein. The hormonal/metabolic alterations in diabetes and starvation might be a model for postnatal development. The sudden interruption of maternal glucose supply signals the enhanced expression of UGT1A1, giving a novel explanation for the physiological induction of bilirubin glucuronidation in newborn infants. |
| doi_str_mv | 10.1042/bj3360587 |
| format | Article |
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In the present study the activity and expression of bilirubin UDP-glucuronosyltransferase (UGT1A1) were investigated in livers of BioBreeding/Worcester diabetic, fasted and acetone-treated rats. Bilirubin glucuronidation was stimulated by all three treatments; this was correlated with an increase in the UGT1A1 protein concentration in hepatic microsomes. Transcriptional induction of UGT1A1 was also observed in diabetes and starvation but not with acetone treatment, which apparently caused translational stabilization of the enzyme protein. The hormonal/metabolic alterations in diabetes and starvation might be a model for postnatal development. The sudden interruption of maternal glucose supply signals the enhanced expression of UGT1A1, giving a novel explanation for the physiological induction of bilirubin glucuronidation in newborn infants.</description><identifier>ISSN: 0264-6021</identifier><identifier>EISSN: 1470-8728</identifier><identifier>DOI: 10.1042/bj3360587</identifier><identifier>PMID: 9841869</identifier><language>eng</language><publisher>England</publisher><subject>Acetone - pharmacology ; Animals ; Diabetes Mellitus, Type 1 - enzymology ; Electrophoresis, Polyacrylamide Gel ; Enzyme Induction ; Glucuronosyltransferase - biosynthesis ; Glucuronosyltransferase - genetics ; Male ; Microsomes, Liver - enzymology ; Rats ; Rats, Inbred BB ; Rats, Wistar ; Starvation - enzymology</subject><ispartof>Biochemical journal, 1998-12, Vol.336 ( Pt 3) (3), p.587-592</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-53e8af8af734c24f2c4592c0d3d2b40a48cdeb009ece602f94d1f5f08fd8398c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1219908/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1219908/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,725,778,782,883,27907,27908,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9841869$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Braun, L</creatorcontrib><creatorcontrib>Coffey, M J</creatorcontrib><creatorcontrib>Puskás, F</creatorcontrib><creatorcontrib>Kardon, T</creatorcontrib><creatorcontrib>Nagy, G</creatorcontrib><creatorcontrib>Conley, A A</creatorcontrib><creatorcontrib>Burchell, B</creatorcontrib><creatorcontrib>Mandl, J</creatorcontrib><title>Molecular basis of bilirubin UDP-glucuronosyltransferase induction in spontaneously diabetic rats, acetone-treated rats and starved rats</title><title>Biochemical journal</title><addtitle>Biochem J</addtitle><description>The co-ordinated induction of several hepatic drug-metabolizing enzymes is a common feature in the regulation of drug biotransformation under normal and pathological conditions. In the present study the activity and expression of bilirubin UDP-glucuronosyltransferase (UGT1A1) were investigated in livers of BioBreeding/Worcester diabetic, fasted and acetone-treated rats. Bilirubin glucuronidation was stimulated by all three treatments; this was correlated with an increase in the UGT1A1 protein concentration in hepatic microsomes. Transcriptional induction of UGT1A1 was also observed in diabetes and starvation but not with acetone treatment, which apparently caused translational stabilization of the enzyme protein. The hormonal/metabolic alterations in diabetes and starvation might be a model for postnatal development. The sudden interruption of maternal glucose supply signals the enhanced expression of UGT1A1, giving a novel explanation for the physiological induction of bilirubin glucuronidation in newborn infants.</description><subject>Acetone - pharmacology</subject><subject>Animals</subject><subject>Diabetes Mellitus, Type 1 - enzymology</subject><subject>Electrophoresis, Polyacrylamide Gel</subject><subject>Enzyme Induction</subject><subject>Glucuronosyltransferase - biosynthesis</subject><subject>Glucuronosyltransferase - genetics</subject><subject>Male</subject><subject>Microsomes, Liver - enzymology</subject><subject>Rats</subject><subject>Rats, Inbred BB</subject><subject>Rats, Wistar</subject><subject>Starvation - enzymology</subject><issn>0264-6021</issn><issn>1470-8728</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUV1rVDEQDWKp2-qDP0DIkyD06uRj7819EaStH9CiD_Y55CaTmpJN1iS3sP_An-3VXRaFgRnOHM7M4RDyksFbBpK_mx6E6GGthidkxeQAnRq4ekpWwHvZ9cDZM3JW6wMAkyDhlJyOSjLVjyvy6zZHtHM0hU6mhkqzp1OIocxTSPTu6lt3H2c7l5xy3cVWTKoei6lIQ3KzbSGnZaJ1m1MzCfNc4466YCZswdJiWr2gxmLLCbtW0DR0f1FqkqO1mfJ4AJ6TE29ixReHfk7uPl5_v_zc3Xz99OXyw01npehbtxaojF9qENJy6bmV65FbcMLxSYKRyjqcAEa0uBj3o3TMrz0o75QYlRXn5P1edztPG3QW02Iq6m0JG1N2Opug_9-k8EPf50fNOBtHUIvA64NAyT9nrE1vQrUY496-HoABFwNbiG_2RFtyrQX98QgD_Sc2fYxt4b7696sj85CT-A3aVpgU</recordid><startdate>19981215</startdate><enddate>19981215</enddate><creator>Braun, L</creator><creator>Coffey, M J</creator><creator>Puskás, F</creator><creator>Kardon, T</creator><creator>Nagy, G</creator><creator>Conley, A A</creator><creator>Burchell, B</creator><creator>Mandl, J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19981215</creationdate><title>Molecular basis of bilirubin UDP-glucuronosyltransferase induction in spontaneously diabetic rats, acetone-treated rats and starved rats</title><author>Braun, L ; Coffey, M J ; Puskás, F ; Kardon, T ; Nagy, G ; Conley, A A ; Burchell, B ; Mandl, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-53e8af8af734c24f2c4592c0d3d2b40a48cdeb009ece602f94d1f5f08fd8398c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Acetone - pharmacology</topic><topic>Animals</topic><topic>Diabetes Mellitus, Type 1 - enzymology</topic><topic>Electrophoresis, Polyacrylamide Gel</topic><topic>Enzyme Induction</topic><topic>Glucuronosyltransferase - biosynthesis</topic><topic>Glucuronosyltransferase - genetics</topic><topic>Male</topic><topic>Microsomes, Liver - enzymology</topic><topic>Rats</topic><topic>Rats, Inbred BB</topic><topic>Rats, Wistar</topic><topic>Starvation - enzymology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Braun, L</creatorcontrib><creatorcontrib>Coffey, M J</creatorcontrib><creatorcontrib>Puskás, F</creatorcontrib><creatorcontrib>Kardon, T</creatorcontrib><creatorcontrib>Nagy, G</creatorcontrib><creatorcontrib>Conley, A A</creatorcontrib><creatorcontrib>Burchell, B</creatorcontrib><creatorcontrib>Mandl, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biochemical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Braun, L</au><au>Coffey, M J</au><au>Puskás, F</au><au>Kardon, T</au><au>Nagy, G</au><au>Conley, A A</au><au>Burchell, B</au><au>Mandl, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular basis of bilirubin UDP-glucuronosyltransferase induction in spontaneously diabetic rats, acetone-treated rats and starved rats</atitle><jtitle>Biochemical journal</jtitle><addtitle>Biochem J</addtitle><date>1998-12-15</date><risdate>1998</risdate><volume>336 ( Pt 3)</volume><issue>3</issue><spage>587</spage><epage>592</epage><pages>587-592</pages><issn>0264-6021</issn><eissn>1470-8728</eissn><abstract>The co-ordinated induction of several hepatic drug-metabolizing enzymes is a common feature in the regulation of drug biotransformation under normal and pathological conditions. 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| ispartof | Biochemical journal, 1998-12, Vol.336 ( Pt 3) (3), p.587-592 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Acetone - pharmacology Animals Diabetes Mellitus, Type 1 - enzymology Electrophoresis, Polyacrylamide Gel Enzyme Induction Glucuronosyltransferase - biosynthesis Glucuronosyltransferase - genetics Male Microsomes, Liver - enzymology Rats Rats, Inbred BB Rats, Wistar Starvation - enzymology |
| title | Molecular basis of bilirubin UDP-glucuronosyltransferase induction in spontaneously diabetic rats, acetone-treated rats and starved rats |
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