Anti-cancer-prostaglandin-induced cell-cycle arrest and its modulation by an inhibitor of the ATP-dependent glutathione S-conjugate export pump (GS-X pump)

The A and J series of prostaglandins (PGs) accumulate in the nuclei to suppress the proliferation of cancer cells. Here we report that Delta7-PGA1 methyl ester, a synthetic anti-cancer PG, increased the level of mRNA for the cyclin-dependent kinase inhibitor p21 in human leukaemia HL-60 cells. The i...

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Veröffentlicht in:	Biochemical journal 1998-12, Vol.336 ( Pt 3) (3), p.569-576
Hauptverfasser:	Ishikawa, T, Akimaru, K, Nakanishi, M, Tomokiyo, K, Furuta, K, Suzuki, M, Noyori, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Antineoplastic Agents - pharmacology Carrier Proteins - antagonists & inhibitors Cell Cycle Cell Division - drug effects Cell Membrane - metabolism Cyclin-Dependent Kinase Inhibitor p21 Cyclins - genetics Cyclins - pharmacology Enzyme Inhibitors - pharmacology Gene Expression Genes, myc Growth Inhibitors - pharmacology HL-60 Cells Humans Membrane Transport Proteins Prostaglandins A, Synthetic - pharmacology RNA, Messenger - metabolism
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