Early steps in glycosylphosphatidylinositol biosynthesis in Leishmania major

A cell-free system based on washed Leishmania major membranes was labelled with GDP-[3H]Man in the presence of synthetic glucosaminyl-phosphatidylinositol (GlcN-PI) and N-acetylglucosaminyl-phosphatidylinositol (GlcNAc-PI). In both cases, the major radiolabelled products were Man alpha 1-4GlcN alpha...

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Veröffentlicht in:	Biochemical journal 1997-09, Vol.326 ( Pt 2) (2), p.393-400
Hauptverfasser:	Smith, T K, Milne, F C, Sharma, D K, Crossman, A, Brimacombe, J S, Ferguson, M A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidohydrolases - metabolism Animals Cell Membrane - enzymology Cell-Free System Glycosylphosphatidylinositols - biosynthesis Leishmania major - enzymology Leishmania major - metabolism Mannosyltransferases - metabolism Polyisoprenyl Phosphate Oligosaccharides - metabolism Substrate Specificity
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