Sphingosine 1-phosphate stimulates rho-mediated tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 fibroblasts

Sphingosine 1-phosphate (SPP), a sphingolipid second messenger implicated in the mitogenic action of platelet-derived growth factor [Olivera, A. and Spiegel, S. (1993) Nature (London) 365, 557-560], induced rapid reorganization of the actin cytoskeleton resulting in stress-fibre formation. SPP also...

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Veröffentlicht in:	Biochemical journal 1997-06, Vol.324 ( Pt 2) (2), p.481-488
Hauptverfasser:	Wang, F, Nobes, C D, Hall, A, Spiegel, S
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells - drug effects 3T3 Cells - enzymology Actin Cytoskeleton - drug effects Actins - metabolism ADP Ribose Transferases - pharmacology Animals Botulinum Toxins Cell Adhesion Molecules - metabolism Cell Division - drug effects Cytoskeletal Proteins - metabolism DNA Replication - drug effects Enzyme Activation - drug effects Focal Adhesion Kinase 1 Focal Adhesion Protein-Tyrosine Kinases GTP-Binding Proteins - physiology Lysophospholipids - antagonists & inhibitors Lysophospholipids - pharmacology Mice Paxillin Phosphoproteins - metabolism Phosphorylation - drug effects Protein Kinase C - antagonists & inhibitors Protein Kinase C - physiology Protein Processing, Post-Translational - drug effects Protein-Tyrosine Kinases - metabolism Recombinant Proteins - pharmacology rho GTP-Binding Proteins Second Messenger Systems Sphingosine - analogs & derivatives Sphingosine - pharmacology Stimulation, Chemical Suramin - pharmacology Tetradecanoylphorbol Acetate - pharmacology
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