Phosphatidylinositol 3,5-bisphosphate defines a novel PI 3-kinase pathway in resting mouse fibroblasts

PtdIns(3,5)P2 is identified as the product of an agonist-independent, wortmannin-sensitive pathway in resting mouse cells. Results are presented here to indicate that PtdIns(3,5)P2 is formed by phosphorylation of PtdIns3P at the D-5 position, and they suggest that relatively constant cellular levels...

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Veröffentlicht in:	Biochemical journal 1997-05, Vol.323 ( Pt 3) (3), p.597-601
Hauptverfasser:	Whiteford, C C, Brearley, C A, Ulug, E T
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstadienes - pharmacology Animals Cell Line Enzyme Inhibitors - pharmacology Fibroblasts - drug effects Fibroblasts - enzymology Interphase Mice Phosphatidylinositol 3-Kinases Phosphatidylinositol Phosphates - metabolism Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors Phosphotransferases (Alcohol Group Acceptor) - metabolism Wortmannin
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