Transgenic mice overexpressing ornithine and S-adenosylmethionine decarboxylases maintain a physiological polyamine homoeostasis in their tissues

Recent work has shown that transgenic mice overexpressing human ornithine decarboxylase display no marked changes in the tissue concentrations of spermidine or spermine in spite of a dramatic increase in putrescine levels. In the tissues of transgenic mice carrying the human spermidine synthase gene...

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Veröffentlicht in:	Biochemical journal 1997-04, Vol.323 ( Pt 2) (2), p.457-462
Hauptverfasser:	Heljasvaara, R, Veress, I, Halmekytö, M, Alhonen, L, Jänne, J, Laajala, P, Pajunen, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosylmethionine Decarboxylase - metabolism Animals Blotting, Northern Brain - metabolism Homeostasis Humans Liver - enzymology Mice Mice, Transgenic Ornithine Decarboxylase - metabolism Polyamines - metabolism Rats RNA - metabolism
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