Structure-activity relationships for chemical and glutathione S-transferase-catalysed glutathione conjugation reactions of a series of 2-substituted 1-chloro-4-nitrobenzenes

Glutathione S-transferases (GSTs) constitute an important class of phase II (de)toxifying enzymes, catalysing the conjugation of glutathione (GSH) with electrophilic compounds. In the present study, Km, kcat and kcat/Km values for the rat GST 1-1-, 3-3-, 4-4- and 7-7-catalysed conjugation reactions...

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Veröffentlicht in:	Biochemical journal 1996-12, Vol.320 ( Pt 2) (2), p.531-540
Hauptverfasser:	Van der Aar, E M, Bouwman, T, Commandeur, J N, Vermeulen, N P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Glutathione Transferase - metabolism Isoenzymes - metabolism Kinetics Models, Chemical Nitrobenzenes - chemistry Nitrobenzenes - metabolism Rats Regression Analysis Structure-Activity Relationship Substrate Specificity
Online-Zugang:	Volltext
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