Primary structures of decapod crustacean metallothioneins with special emphasis on freshwater and semi-terrestrial species
Cadmium injections induced only a single form of metallothionein (MT) in the midgut gland of Potamon potamios, whereas the same treatment induced two isoforms in Astacus astacus. The only difference between the two latter isoforms was that one had an extra N-terminal methionine residue. MT from P. p...
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| Veröffentlicht in: | Biochemical journal 1996-11, Vol.319 ( Pt 3) (3), p.999-1003 |
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| creator | Pedersen, S N Pedersen, K L Højrup, P Depledge, M H Knudsen, J |
| description | Cadmium injections induced only a single form of metallothionein (MT) in the midgut gland of Potamon potamios, whereas the same treatment induced two isoforms in Astacus astacus. The only difference between the two latter isoforms was that one had an extra N-terminal methionine residue. MT from P. potamios showed structural differences from other decapod crustacean MTs. It contained a Gly-Thr motif at positions 8 and 8a, which had previously been found only in certain vertebrate and molluscan MTs. Furthermore P. potamios MT contained two to three times as many glutamic acid residues as normally found in decapod crustacean MT. The primary structure of MT from the freshwater crayfish A. astacus showed a high degree of sequence identity with MT from other decapod crustaceans, especially the marine astacidean Homarus americanus, although two valine residues were unexpectedly found at positions 8 and 21, where lysine residues are normally found. |
| doi_str_mv | 10.1042/bj3190999 |
| format | Article |
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The only difference between the two latter isoforms was that one had an extra N-terminal methionine residue. MT from P. potamios showed structural differences from other decapod crustacean MTs. It contained a Gly-Thr motif at positions 8 and 8a, which had previously been found only in certain vertebrate and molluscan MTs. Furthermore P. potamios MT contained two to three times as many glutamic acid residues as normally found in decapod crustacean MT. The primary structure of MT from the freshwater crayfish A. astacus showed a high degree of sequence identity with MT from other decapod crustaceans, especially the marine astacidean Homarus americanus, although two valine residues were unexpectedly found at positions 8 and 21, where lysine residues are normally found.</description><identifier>ISSN: 0264-6021</identifier><identifier>EISSN: 1470-8728</identifier><identifier>DOI: 10.1042/bj3190999</identifier><identifier>PMID: 8921011</identifier><language>eng</language><publisher>England</publisher><subject>Amino Acid Sequence ; Animals ; Astacus astacus ; Brachyura ; Cadmium - pharmacology ; Chromatography, High Pressure Liquid ; Crustacea - metabolism ; Fishes ; Fresh Water ; Freshwater ; Humans ; Mass Spectrometry ; Metallothionein - biosynthesis ; Metallothionein - chemistry ; Metallothionein - isolation & purification ; Molecular Sequence Data ; Mollusca ; Nephropidae ; Peptide Fragments - chemistry ; Peptide Fragments - isolation & purification ; Peptide Mapping ; Potamon potamios ; Seawater ; Sequence Homology, Amino Acid ; Species Specificity</subject><ispartof>Biochemical journal, 1996-11, Vol.319 ( Pt 3) (3), p.999-1003</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-fb9ba13395290c2a5354a8eaae276c9a944b1e219f8068c1604eafbe3357393</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1217887/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1217887/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8921011$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pedersen, S N</creatorcontrib><creatorcontrib>Pedersen, K L</creatorcontrib><creatorcontrib>Højrup, P</creatorcontrib><creatorcontrib>Depledge, M H</creatorcontrib><creatorcontrib>Knudsen, J</creatorcontrib><title>Primary structures of decapod crustacean metallothioneins with special emphasis on freshwater and semi-terrestrial species</title><title>Biochemical journal</title><addtitle>Biochem J</addtitle><description>Cadmium injections induced only a single form of metallothionein (MT) in the midgut gland of Potamon potamios, whereas the same treatment induced two isoforms in Astacus astacus. The only difference between the two latter isoforms was that one had an extra N-terminal methionine residue. MT from P. potamios showed structural differences from other decapod crustacean MTs. It contained a Gly-Thr motif at positions 8 and 8a, which had previously been found only in certain vertebrate and molluscan MTs. Furthermore P. potamios MT contained two to three times as many glutamic acid residues as normally found in decapod crustacean MT. The primary structure of MT from the freshwater crayfish A. astacus showed a high degree of sequence identity with MT from other decapod crustaceans, especially the marine astacidean Homarus americanus, although two valine residues were unexpectedly found at positions 8 and 21, where lysine residues are normally found.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Astacus astacus</subject><subject>Brachyura</subject><subject>Cadmium - pharmacology</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Crustacea - metabolism</subject><subject>Fishes</subject><subject>Fresh Water</subject><subject>Freshwater</subject><subject>Humans</subject><subject>Mass Spectrometry</subject><subject>Metallothionein - biosynthesis</subject><subject>Metallothionein - chemistry</subject><subject>Metallothionein - isolation & purification</subject><subject>Molecular Sequence Data</subject><subject>Mollusca</subject><subject>Nephropidae</subject><subject>Peptide Fragments - chemistry</subject><subject>Peptide Fragments - isolation & purification</subject><subject>Peptide Mapping</subject><subject>Potamon potamios</subject><subject>Seawater</subject><subject>Sequence Homology, Amino Acid</subject><subject>Species Specificity</subject><issn>0264-6021</issn><issn>1470-8728</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV-L1TAQxYO4rNfVBz-AkCfBh2omSdvkRZDFf7CwC_peprlTm6VtapK6uJ_erPdy0Sefhpn5zeEMh7EXIN6A0PJtf6vACmvtI7YD3YrKtNI8ZjshG101QsIT9jSlWyFACy3O2bmxEgTAjt3fRD9j_MVTjpvLW6TEw8D35HANe-7iljI6woXPlHGaQh59WMgvid_5PPK0kvM4cZrXEZMvxwsfish4h5kix2XPE82-Kk2Z5vjA_rmh9IydDTglen6sF-zrxw_fLj9XV9efvly-v6qcFpCrobc9glK2llY4ibWqNRpCJNk2zqLVugeSYAcjGuOgEZpw6EmpulVWXbB3B9V162faO1pyxKlbD293AX3372bxY_c9_OxAQmtMWwReHQVi-LGVH7rZJ0fThAuFLXWtqZVR8v9gcdZoEE0BXx9AF0NKkYaTGxDdQ57dKc_Cvvzb_ok8Bqh-Ax96nyQ</recordid><startdate>19961101</startdate><enddate>19961101</enddate><creator>Pedersen, S N</creator><creator>Pedersen, K L</creator><creator>Højrup, P</creator><creator>Depledge, M H</creator><creator>Knudsen, J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19961101</creationdate><title>Primary structures of decapod crustacean metallothioneins with special emphasis on freshwater and semi-terrestrial species</title><author>Pedersen, S N ; Pedersen, K L ; Højrup, P ; Depledge, M H ; Knudsen, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-fb9ba13395290c2a5354a8eaae276c9a944b1e219f8068c1604eafbe3357393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Astacus astacus</topic><topic>Brachyura</topic><topic>Cadmium - pharmacology</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Crustacea - metabolism</topic><topic>Fishes</topic><topic>Fresh Water</topic><topic>Freshwater</topic><topic>Humans</topic><topic>Mass Spectrometry</topic><topic>Metallothionein - biosynthesis</topic><topic>Metallothionein - chemistry</topic><topic>Metallothionein - isolation & purification</topic><topic>Molecular Sequence Data</topic><topic>Mollusca</topic><topic>Nephropidae</topic><topic>Peptide Fragments - chemistry</topic><topic>Peptide Fragments - isolation & purification</topic><topic>Peptide Mapping</topic><topic>Potamon potamios</topic><topic>Seawater</topic><topic>Sequence Homology, Amino Acid</topic><topic>Species Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pedersen, S N</creatorcontrib><creatorcontrib>Pedersen, K L</creatorcontrib><creatorcontrib>Højrup, P</creatorcontrib><creatorcontrib>Depledge, M H</creatorcontrib><creatorcontrib>Knudsen, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biochemical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pedersen, S N</au><au>Pedersen, K L</au><au>Højrup, P</au><au>Depledge, M H</au><au>Knudsen, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Primary structures of decapod crustacean metallothioneins with special emphasis on freshwater and semi-terrestrial species</atitle><jtitle>Biochemical journal</jtitle><addtitle>Biochem J</addtitle><date>1996-11-01</date><risdate>1996</risdate><volume>319 ( Pt 3)</volume><issue>3</issue><spage>999</spage><epage>1003</epage><pages>999-1003</pages><issn>0264-6021</issn><eissn>1470-8728</eissn><abstract>Cadmium injections induced only a single form of metallothionein (MT) in the midgut gland of Potamon potamios, whereas the same treatment induced two isoforms in Astacus astacus. The only difference between the two latter isoforms was that one had an extra N-terminal methionine residue. MT from P. potamios showed structural differences from other decapod crustacean MTs. It contained a Gly-Thr motif at positions 8 and 8a, which had previously been found only in certain vertebrate and molluscan MTs. Furthermore P. potamios MT contained two to three times as many glutamic acid residues as normally found in decapod crustacean MT. The primary structure of MT from the freshwater crayfish A. astacus showed a high degree of sequence identity with MT from other decapod crustaceans, especially the marine astacidean Homarus americanus, although two valine residues were unexpectedly found at positions 8 and 21, where lysine residues are normally found.</abstract><cop>England</cop><pmid>8921011</pmid><doi>10.1042/bj3190999</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Amino Acid Sequence Animals Astacus astacus Brachyura Cadmium - pharmacology Chromatography, High Pressure Liquid Crustacea - metabolism Fishes Fresh Water Freshwater Humans Mass Spectrometry Metallothionein - biosynthesis Metallothionein - chemistry Metallothionein - isolation & purification Molecular Sequence Data Mollusca Nephropidae Peptide Fragments - chemistry Peptide Fragments - isolation & purification Peptide Mapping Potamon potamios Seawater Sequence Homology, Amino Acid Species Specificity |
| title | Primary structures of decapod crustacean metallothioneins with special emphasis on freshwater and semi-terrestrial species |
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