High rates of extracellular superoxide generation by cultured human fibroblasts: involvement of a lipid-metabolizing enzyme

Expression of NADPH oxidase and low superoxide generation (approx. 0.06 nmol/min per 10(6) cells) by cytokine- or ionophore-stimulated human fibroblasts is known. However, we here show that these cells also contain an ectoplasmic enzyme, distinct from NADPH oxidase, which can generate superoxide (2....

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Veröffentlicht in:	Biochemical journal 1996-09, Vol.318 ( Pt 3) (3), p.805-812
Hauptverfasser:	O'Donnell, V B, Azzi, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonate 15-Lipoxygenase - metabolism Cell Line Cytochrome c Group - metabolism Electron Transport Extracellular Space - metabolism Fatty Acids - metabolism Fibroblasts - metabolism Humans Kinetics Lipid Metabolism Luminescent Measurements NAD - metabolism NAD - pharmacology NADP - metabolism NADP - pharmacology NADPH Oxidases - metabolism Oxidation-Reduction Rabbits Reactive Oxygen Species - metabolism Recombinant Proteins - metabolism Superoxides - metabolism
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