The proximal element of the human apolipoprotein A-II promoter increases the enhancer activity of the distal region

We have previously shown that human apolipoprotein A-II (apoA-II) transcription is controlled by a complex set of regulatory elements. In this study, we demonstrate that the distal region of the apoA-II promoter (-911/-614) acts as an enhancer and results in a 6-fold increase in activity when the pr...

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Veröffentlicht in:	Biochemical journal 1996-09, Vol.318 ( Pt 2) (2), p.681-688
Hauptverfasser:	Lacorte, J M, Fourniat, E, Pastier, D, Chambaz, J, Ribeiro, A, Cardot, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoprotein A-II - biosynthesis Apolipoprotein A-II - genetics Base Sequence Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Binding Sites Cercopithecus aethiops Chloramphenicol O-Acetyltransferase - biosynthesis COS Cells DNA Primers DNA-Binding Proteins - metabolism Enhancer Elements, Genetic Gene Expression Regulation, Enzymologic Hepatocyte Nuclear Factor 4 Humans Mutagenesis, Site-Directed Phosphoproteins - metabolism Polymerase Chain Reaction Promoter Regions, Genetic Recombinant Fusion Proteins - biosynthesis TATA Box Transcription Factors - metabolism Transcription, Genetic Transcriptional Activation Transfection
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