A type 2A phosphatase-sensitive phosphorylation site controls modal gating of L-type Ca2+ channels in human vascular smooth-muscle cells

The patch-clamp technique was employed to investigate phosphorylation/dephosphorylation-dependent modulation of L-type Ca2+ channels in smooth-muscle cells isolated from human umbilical vein. Okadaic acid, an inhibitor of phosphoprotein phosphatases type 1 (PP1) and 2A (PP2A), increased the probabil...

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Veröffentlicht in:	Biochemical journal 1996-09, Vol.318 ( Pt 2) (2), p.513-517
Hauptverfasser:	Groschner, K, Schuhmann, K, Mieskes, G, Baumgartner, W, Romanin, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium Channels - drug effects Calcium Channels - physiology Calcium Channels, L-Type Enzyme Inhibitors - pharmacology Humans Ion Channel Gating Kinetics Models, Biological Muscle, Smooth, Vascular - physiology Okadaic Acid - pharmacology Patch-Clamp Techniques Phosphoprotein Phosphatases - antagonists & inhibitors Phosphoprotein Phosphatases - metabolism Phosphorylation Time Factors Umbilical Veins - physiology
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