Effects of insulin on the regulation of branched-chain alpha-keto acid dehydrogenase E1 alpha subunit gene expression

Alterations in dietary intake, especially of protein, may produce changes in the hepatic levels of the branched-chain alpha-keto acid dehydrogenase (BCKAD) complex. The possible role of insulin in the regulation of these observed changes in hepatic capacity for BCKAD expression was therefore examine...

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Veröffentlicht in:	Biochemical journal 1996-08, Vol.318 ( Pt 1) (1), p.85-92
Hauptverfasser:	Costeas, P A, Chinsky, J M
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) Amino Acid Sequence Animals Base Sequence Blotting, Northern Blotting, Western Cloning, Molecular Dietary Carbohydrates - administration & dosage Dietary Proteins - administration & dosage Gene Expression Regulation, Enzymologic - drug effects Insulin - pharmacology Insulin - physiology Ketone Oxidoreductases - chemistry Ketone Oxidoreductases - genetics Ketone Oxidoreductases - metabolism Liver - enzymology Mice Mice, Inbred C57BL Molecular Sequence Data Multienzyme Complexes - chemistry Multienzyme Complexes - genetics Multienzyme Complexes - metabolism Rats Ribosomal Proteins - metabolism RNA, Messenger - metabolism Starvation Tumor Cells, Cultured
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