Cold-induced reduction in Gi alpha proteins in brown adipose tissue. Effects on the cellular hypersensitization to noradrenaline caused by pertussis-toxin treatment

The significance of Gi proteins for the physiological desensitization phenomena observed in brown-fat cells from cold-acclimated hamsters was investigated. For this purpose, pertussis toxin (the inhibitor of Gi function) was injected into control and cold-acclimated hamsters. After 3 days the thermo...

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Veröffentlicht in:	Biochemical journal 1996-03, Vol.314 ( Pt 3) (3), p.761-768
Hauptverfasser:	Svoboda, P, Unelius, L, Dicker, A, Cannon, B, Milligan, G, Nedergaard, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acclimatization Adenylate Cyclase Toxin Adipose Tissue, Brown - drug effects Adipose Tissue, Brown - metabolism Amino Acid Sequence Animals Body Temperature Regulation Cell Membrane - drug effects Cell Membrane - metabolism Cold Temperature Cricetinae Electrophoresis, Polyacrylamide Gel Female GTP-Binding Proteins - analysis GTP-Binding Proteins - metabolism Immune Sera Immunoblotting Kinetics Male Mesocricetus Molecular Sequence Data Norepinephrine - pharmacology Peptide Fragments - chemical synthesis Peptide Fragments - chemistry Peptide Fragments - immunology Pertussis Toxin Virulence Factors, Bordetella - pharmacology
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