Antigenicity and conformational analysis of the Zn(2+)-binding sites of two Zn(2+)-metalloproteases: Leishmania gp63 and mammalian endopeptidase-24.11

The antigenic properties of the Zn(2+)-binding region of two Zn(2+)-metalloproteases, Leishmania surface protease gp63 and mammalian endopeptidase-24.11 (E-24.11), possessing in their active site the characteristic amino acid sequence HEXXH, were investigated by using oligoclonal antibodies raised a...

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Veröffentlicht in:	Biochemical journal 1996-01, Vol.313 ( Pt 2) (Pt 2), p.455-466
Hauptverfasser:	Soteriadou, K P, Tzinia, A K, Panou-Pamonis, E, Tsikaris, V, Sakarellos-Daitsiotis, M, Sakarellos, C, Papapoulou, Y, Matsas, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies, Monoclonal - immunology Antigens, Protozoan - chemistry Antigens, Protozoan - immunology Antigens, Protozoan - metabolism Binding Sites Humans Kidney - enzymology Leishmania - enzymology Leishmania - immunology Leishmania - metabolism Magnetic Resonance Spectroscopy Metalloendopeptidases - chemistry Metalloendopeptidases - immunology Metalloendopeptidases - metabolism Molecular Sequence Data Neprilysin - chemistry Neprilysin - immunology Neprilysin - metabolism Sequence Homology, Amino Acid Substrate Specificity Swine Zinc - metabolism
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