Genetic control of phosphorus assimilation in Neurospora crassa : dose-dependent dominance and recessiveness in constitutive mutants
Mutants called nuc-1c, constitutive for alkaline phosphatase synthesis, were isolated and mapped very close to nuc-1 mutants in which this enzyme is not expressed. nuc-1 is epistatic to nuc-1c. nuc-1c acts only if it is cis to normal nuc-1 function. The preparation of partial diploids heterozygous f...
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| Veröffentlicht in: | Genetics (Austin) 1979-11, Vol.93 (3), p.625-643 |
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| creator | Metzenberg, R.L Chia, W |
| description | Mutants called nuc-1c, constitutive for alkaline phosphatase synthesis, were isolated and mapped very close to nuc-1 mutants in which this enzyme is not expressed. nuc-1 is epistatic to nuc-1c. nuc-1c acts only if it is cis to normal nuc-1 function. The preparation of partial diploids heterozygous for various nuc-1 alleles is described; nuc-1c is dominant to nuc-1+, which in turn is dominant to nuc-1. In heterocaryons with nuc-1+, nuc-1c is dominant when it is present in high proportion, but essentially recessive if it is present in low proportions. In heterocaryons with nuc-1, nuc-1c is again dominant when present in high proportions, but in low proportions it "complements" to give essentially normal repressibility. A model of regulation consistent with these findings is presented. |
| doi_str_mv | 10.1093/genetics/93.3.625 |
| format | Article |
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The preparation of partial diploids heterozygous for various nuc-1 alleles is described; nuc-1c is dominant to nuc-1+, which in turn is dominant to nuc-1. In heterocaryons with nuc-1+, nuc-1c is dominant when it is present in high proportion, but essentially recessive if it is present in low proportions. In heterocaryons with nuc-1, nuc-1c is again dominant when present in high proportions, but in low proportions it "complements" to give essentially normal repressibility. A model of regulation consistent with these findings is presented.</description><identifier>ISSN: 0016-6731</identifier><identifier>ISSN: 1943-2631</identifier><identifier>EISSN: 1943-2631</identifier><identifier>DOI: 10.1093/genetics/93.3.625</identifier><identifier>PMID: 161751</identifier><language>eng</language><publisher>United States: Genetics Soc America</publisher><subject>Alkaline Phosphatase - genetics ; Cell Nucleus ; Epistasis, Genetic ; fungi ; Genes ; Heterozygote ; Investigations ; Mutation ; Neurospora - genetics ; Neurospora crassa - cytology ; Neurospora crassa - genetics ; Phosphorus - metabolism</subject><ispartof>Genetics (Austin), 1979-11, Vol.93 (3), p.625-643</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-47e87d9c0c81f31a327d775c04ff3be34849dcf9d162cf4a336f54e16f6cb0d73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/161751$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Metzenberg, R.L</creatorcontrib><creatorcontrib>Chia, W</creatorcontrib><title>Genetic control of phosphorus assimilation in Neurospora crassa : dose-dependent dominance and recessiveness in constitutive mutants</title><title>Genetics (Austin)</title><addtitle>Genetics</addtitle><description>Mutants called nuc-1c, constitutive for alkaline phosphatase synthesis, were isolated and mapped very close to nuc-1 mutants in which this enzyme is not expressed. nuc-1 is epistatic to nuc-1c. nuc-1c acts only if it is cis to normal nuc-1 function. The preparation of partial diploids heterozygous for various nuc-1 alleles is described; nuc-1c is dominant to nuc-1+, which in turn is dominant to nuc-1. In heterocaryons with nuc-1+, nuc-1c is dominant when it is present in high proportion, but essentially recessive if it is present in low proportions. In heterocaryons with nuc-1, nuc-1c is again dominant when present in high proportions, but in low proportions it "complements" to give essentially normal repressibility. A model of regulation consistent with these findings is presented.</description><subject>Alkaline Phosphatase - genetics</subject><subject>Cell Nucleus</subject><subject>Epistasis, Genetic</subject><subject>fungi</subject><subject>Genes</subject><subject>Heterozygote</subject><subject>Investigations</subject><subject>Mutation</subject><subject>Neurospora - genetics</subject><subject>Neurospora crassa - cytology</subject><subject>Neurospora crassa - genetics</subject><subject>Phosphorus - metabolism</subject><issn>0016-6731</issn><issn>1943-2631</issn><issn>1943-2631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplUsuOFCEUJcZXO_oBGhPZ6K56uAUFVS5MzERHk4kudNaE5tGNqYIeoKbj3g-XtkYdYwLhcc4994QDQk-BrIEM9HRrgy1e59OBrumat90dtIKB0ablFO6iFSHAGy4oPESPcv5GCOFD1z9A94GD6GCFfpwvCljHUFIccXR4v4u5zjRnrHL2kx9V8TFgH_AnO6cKxqSwThVU-DU2MdvG2L0NxoZSj5MPKmiLVTA4WW2rxnXtkvNRofbJxZe51Ds8zUWFkh-je06N2T65WU_Q5ft3X88-NBefzz-evb1oNOO8NEzYXphBE92Do6BoK4wQnSbMObqxlPVsMNoNBnirHVOUctcxC9xxvSFG0BP0ZtHdz5vJGl3tJjXKffKTSt9lVF7-iwS_k9t4LaEFBqStAq9uBFK8mm0ucvJZ23FUwcY5S8EGwQU7EmEh6vpcOVn3pwkQeUxO_k5O1j2VNbla8_y2u78Vv6Kq8MsF3vnt7uCTlXlS41jJIA-Hwy2ZZwvPqSjVNvksL7_0NXgKR18v_gdbArQOWv-NoD8B0_y6aQ</recordid><startdate>19791101</startdate><enddate>19791101</enddate><creator>Metzenberg, R.L</creator><creator>Chia, W</creator><general>Genetics Soc America</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19791101</creationdate><title>Genetic control of phosphorus assimilation in Neurospora crassa : dose-dependent dominance and recessiveness in constitutive mutants</title><author>Metzenberg, R.L ; Chia, W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-47e87d9c0c81f31a327d775c04ff3be34849dcf9d162cf4a336f54e16f6cb0d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Alkaline Phosphatase - genetics</topic><topic>Cell Nucleus</topic><topic>Epistasis, Genetic</topic><topic>fungi</topic><topic>Genes</topic><topic>Heterozygote</topic><topic>Investigations</topic><topic>Mutation</topic><topic>Neurospora - genetics</topic><topic>Neurospora crassa - cytology</topic><topic>Neurospora crassa - genetics</topic><topic>Phosphorus - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Metzenberg, R.L</creatorcontrib><creatorcontrib>Chia, W</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genetics (Austin)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Metzenberg, R.L</au><au>Chia, W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic control of phosphorus assimilation in Neurospora crassa : dose-dependent dominance and recessiveness in constitutive mutants</atitle><jtitle>Genetics (Austin)</jtitle><addtitle>Genetics</addtitle><date>1979-11-01</date><risdate>1979</risdate><volume>93</volume><issue>3</issue><spage>625</spage><epage>643</epage><pages>625-643</pages><issn>0016-6731</issn><issn>1943-2631</issn><eissn>1943-2631</eissn><abstract>Mutants called nuc-1c, constitutive for alkaline phosphatase synthesis, were isolated and mapped very close to nuc-1 mutants in which this enzyme is not expressed. nuc-1 is epistatic to nuc-1c. nuc-1c acts only if it is cis to normal nuc-1 function. The preparation of partial diploids heterozygous for various nuc-1 alleles is described; nuc-1c is dominant to nuc-1+, which in turn is dominant to nuc-1. In heterocaryons with nuc-1+, nuc-1c is dominant when it is present in high proportion, but essentially recessive if it is present in low proportions. In heterocaryons with nuc-1, nuc-1c is again dominant when present in high proportions, but in low proportions it "complements" to give essentially normal repressibility. A model of regulation consistent with these findings is presented.</abstract><cop>United States</cop><pub>Genetics Soc America</pub><pmid>161751</pmid><doi>10.1093/genetics/93.3.625</doi><tpages>19</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0016-6731 |
| ispartof | Genetics (Austin), 1979-11, Vol.93 (3), p.625-643 |
| issn | 0016-6731 1943-2631 1943-2631 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1214102 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Alkaline Phosphatase - genetics Cell Nucleus Epistasis, Genetic fungi Genes Heterozygote Investigations Mutation Neurospora - genetics Neurospora crassa - cytology Neurospora crassa - genetics Phosphorus - metabolism |
| title | Genetic control of phosphorus assimilation in Neurospora crassa : dose-dependent dominance and recessiveness in constitutive mutants |
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