The study of genic variation by electrophoretic and heat denaturation techniques at the octanol dehydrogenase locus in members of the Drosophila virilis group
Heat denaturation studies of three different electrophoretic allozymes of octanol dehydrogenase were performed from 10 species of the Drosophila virilis group. A total of 18 alleles were discovered, and in 3 species in which electrophoretic studies indicated that the locus was monomorphic, heat dena...
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| Veröffentlicht in: | Genetics (Austin) 1975-07, Vol.80 (3), p.637-650 |
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| container_title | Genetics (Austin) |
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| creator | Singh, R.S Hubby, J.L Throckmorton, L.H |
| description | Heat denaturation studies of three different electrophoretic allozymes of octanol dehydrogenase were performed from 10 species of the Drosophila virilis group. A total of 18 alleles were discovered, and in 3 species in which electrophoretic studies indicated that the locus was monomorphic, heat denaturation showed that the locus was polymorphic. We show that electrophoretic studies underestimate the number of alleles at this locus by a factor of 2.6 in these species. The results are discussed in the light of the continuing controversy over selection and neutral theories of genetic variation. |
| doi_str_mv | 10.1093/genetics/80.3.637 |
| format | Article |
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A total of 18 alleles were discovered, and in 3 species in which electrophoretic studies indicated that the locus was monomorphic, heat denaturation showed that the locus was polymorphic. We show that electrophoretic studies underestimate the number of alleles at this locus by a factor of 2.6 in these species. 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A total of 18 alleles were discovered, and in 3 species in which electrophoretic studies indicated that the locus was monomorphic, heat denaturation showed that the locus was polymorphic. We show that electrophoretic studies underestimate the number of alleles at this locus by a factor of 2.6 in these species. The results are discussed in the light of the continuing controversy over selection and neutral theories of genetic variation.</description><subject>Alcohol Oxidoreductases - biosynthesis</subject><subject>Animals</subject><subject>Drosophila - enzymology</subject><subject>Electrophoresis</subject><subject>Female</subject><subject>Genetic Variation</subject><subject>Hot Temperature</subject><subject>Investigations</subject><subject>Male</subject><subject>Polymorphism, Genetic</subject><subject>Protein Denaturation</subject><subject>Selection, Genetic</subject><subject>Species Specificity</subject><issn>0016-6731</issn><issn>1943-2631</issn><issn>1943-2631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc1u1DAURiMEKtPCA4CE5A3sMvVP4iQbpKpQQKrEgnZteezrxMiJB9uZ0bwMz4pDCpSVF9-557N9i-IVwVuCO3bZwwTJqnjZ4i3bctY8KTakq1hJOSNPiw3GhJe8YeR5cR7jd4wx7-r2rDgjlFFMu03x824AFNOsT8gblH1WoYMMVibrJ7Q7IXCgUvD7wYelCslJowFkQhommeawggnUMNkfM0SUo5SdXiU5eZex4aSDz2YZATmv5ojshEYYdxDiUrrQH4KPucM6iQ42WGcj6oOf9y-KZ0a6CC8fzovi_ubj3fXn8vbrpy_XV7elqmjVlF2LsdzpuuMtq0zHasBAjKEd1o1hmmGlgVbGNJXUTd01SlaUkDxEqaoJa9hF8X717ufdCFrBlIJ0Yh_sKMNJeGnF_8lkB9H7gyCUMMbrLHj3IAh--YYkRhsVOCcn8HMULWOEtQxnkKygyk-OAczfEoLFslTxZ6mixYIJ_vt2bx7f7t_EusWcv13zwfbD0QYQcZTOZZqI4_H4yPN65Yz0QvbBRnH_reG45bn3F4Knudg</recordid><startdate>19750701</startdate><enddate>19750701</enddate><creator>Singh, R.S</creator><creator>Hubby, J.L</creator><creator>Throckmorton, L.H</creator><general>Genetics Soc America</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19750701</creationdate><title>The study of genic variation by electrophoretic and heat denaturation techniques at the octanol dehydrogenase locus in members of the Drosophila virilis group</title><author>Singh, R.S ; Hubby, J.L ; Throckmorton, L.H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4247-9800abd596834f935e0e1ff290d7f3d30cde24ff74ad7597ca421180022c51373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Alcohol Oxidoreductases - biosynthesis</topic><topic>Animals</topic><topic>Drosophila - enzymology</topic><topic>Electrophoresis</topic><topic>Female</topic><topic>Genetic Variation</topic><topic>Hot Temperature</topic><topic>Investigations</topic><topic>Male</topic><topic>Polymorphism, Genetic</topic><topic>Protein Denaturation</topic><topic>Selection, Genetic</topic><topic>Species Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Singh, R.S</creatorcontrib><creatorcontrib>Hubby, J.L</creatorcontrib><creatorcontrib>Throckmorton, L.H</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genetics (Austin)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singh, R.S</au><au>Hubby, J.L</au><au>Throckmorton, L.H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The study of genic variation by electrophoretic and heat denaturation techniques at the octanol dehydrogenase locus in members of the Drosophila virilis group</atitle><jtitle>Genetics (Austin)</jtitle><addtitle>Genetics</addtitle><date>1975-07-01</date><risdate>1975</risdate><volume>80</volume><issue>3</issue><spage>637</spage><epage>650</epage><pages>637-650</pages><issn>0016-6731</issn><issn>1943-2631</issn><eissn>1943-2631</eissn><abstract>Heat denaturation studies of three different electrophoretic allozymes of octanol dehydrogenase were performed from 10 species of the Drosophila virilis group. A total of 18 alleles were discovered, and in 3 species in which electrophoretic studies indicated that the locus was monomorphic, heat denaturation showed that the locus was polymorphic. We show that electrophoretic studies underestimate the number of alleles at this locus by a factor of 2.6 in these species. The results are discussed in the light of the continuing controversy over selection and neutral theories of genetic variation.</abstract><cop>United States</cop><pub>Genetics Soc America</pub><pmid>1232029</pmid><doi>10.1093/genetics/80.3.637</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0016-6731 |
| ispartof | Genetics (Austin), 1975-07, Vol.80 (3), p.637-650 |
| issn | 0016-6731 1943-2631 1943-2631 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1213365 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Alcohol Oxidoreductases - biosynthesis Animals Drosophila - enzymology Electrophoresis Female Genetic Variation Hot Temperature Investigations Male Polymorphism, Genetic Protein Denaturation Selection, Genetic Species Specificity |
| title | The study of genic variation by electrophoretic and heat denaturation techniques at the octanol dehydrogenase locus in members of the Drosophila virilis group |
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