DIRECTED EVOLUTION OF METABOLIC PATHWAYS IN MICROBIAL POPULATIONS. I. MODIFICATION OF THE ACID PHOSPHATASE pH OPTIMUM IN S. CEREVISIAE

An experimental system for directing the evolution of enzymes and metabolic pathways in microbial populations is proposed and an initial test of its power is provided.-The test involved an attempt to genetically enhance certain functional properties of the enzyme acid phosphatase in S. cerevisiae by...

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Veröffentlicht in:	Genetics (Austin) 1972-01, Vol.70 (1), p.59-73
Hauptverfasser:	Francis, J. C, Hansche, P. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Phosphatase - analysis Adaptation, Physiological Biological Evolution Cell Count Cell Division Cell Survival Culture Media Genes Glycerophosphates - metabolism Hydrogen-Ion Concentration Investigations Kinetics Models, Biological Mutation Nutritional Requirements Phosphates - analysis Phosphates - metabolism Saccharomyces - enzymology Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - growth & development Selection, Genetic Spores, Fungal
Online-Zugang:	Volltext
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