hitchhiking effect on the site frequency spectrum of DNA polymorphisms

The level of DNA sequence variation is reduced in regions of the Drosophila melanogaster genome where the rate of crossing over per physical distance is also reduced. This observation has been interpreted as support for the simple model of genetic hitchhiking, in which directional selection on rare...

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Veröffentlicht in:	Genetics (Austin) 1995-06, Vol.140 (2), p.783-796
Hauptverfasser:	Braverman, J.M, Hudson, R.R, Kaplan, N.L, Langley, C.H, Stephan, W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals computer simulation crossing over Deoxyribonucleic acid DNA DNA - genetics dna sequence polymorphism Drosophila melanogaster Drosophila melanogaster - genetics genetic hitchhiking genetic models genetic polymorphism Genetic Variation Genetics genome Insects Investigations loci Models, Genetic mutation Polymorphism, Genetic regions of restricted crossing over simulation models tajima' test
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