Characterization of the mus308 gene in Drosophila melanogaster
Among the available mutagen-sensitive mutations in Drosophila, those at the mus308 locus are unique in conferring hypersensitivity to DNA cross-linking agents but not to monofunctional agents. Those mutations are also associated with an elevated frequency of chromosomal aberrations, altered DNA meta...
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| Veröffentlicht in: | Genetics (Austin) 1993-01, Vol.133 (1), p.87-96 |
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| creator | Leonhardt, E.A. (University of California, San Francisco, CA) Henderson, D.S Rinehart, J.E Boyd, J.B |
| description | Among the available mutagen-sensitive mutations in Drosophila, those at the mus308 locus are unique in conferring hypersensitivity to DNA cross-linking agents but not to monofunctional agents. Those mutations are also associated with an elevated frequency of chromosomal aberrations, altered DNA metabolism and the modification of a deoxyribonuclease. This spectrum of phenotypes is shared with selected mammalian mutations including Fanconi anemia in humans. In anticipation of the molecular characterization of the mus308 gene, it has been localized cytogenetically to 87C9-87D1,2 on the right arm of chromosome three. Nine new mutant alleles of the gene have been generated by X-ray mutagenesis and one was recovered following hybrid dysgenesis. Characterization of these new alleles has uncovered additional phenotypes of mutations at this locus. Homozygous mus308 flies that have survived moderate mutagen treatment exhibit an altered wing position that is correlated with reduced flight ability and an altered mitochondria morphology. In addition, observations of elevated embryo mortality are potentially explained by an aberrant distribution of nuclear material in early embryos which is similar to that seen in the mutant giant nuclei |
| doi_str_mv | 10.1093/genetics/133.1.87 |
| format | Article |
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(University of California, San Francisco, CA) ; Henderson, D.S ; Rinehart, J.E ; Boyd, J.B</creator><creatorcontrib>Leonhardt, E.A. (University of California, San Francisco, CA) ; Henderson, D.S ; Rinehart, J.E ; Boyd, J.B</creatorcontrib><description>Among the available mutagen-sensitive mutations in Drosophila, those at the mus308 locus are unique in conferring hypersensitivity to DNA cross-linking agents but not to monofunctional agents. Those mutations are also associated with an elevated frequency of chromosomal aberrations, altered DNA metabolism and the modification of a deoxyribonuclease. This spectrum of phenotypes is shared with selected mammalian mutations including Fanconi anemia in humans. In anticipation of the molecular characterization of the mus308 gene, it has been localized cytogenetically to 87C9-87D1,2 on the right arm of chromosome three. Nine new mutant alleles of the gene have been generated by X-ray mutagenesis and one was recovered following hybrid dysgenesis. Characterization of these new alleles has uncovered additional phenotypes of mutations at this locus. Homozygous mus308 flies that have survived moderate mutagen treatment exhibit an altered wing position that is correlated with reduced flight ability and an altered mitochondria morphology. In addition, observations of elevated embryo mortality are potentially explained by an aberrant distribution of nuclear material in early embryos which is similar to that seen in the mutant giant nuclei</description><identifier>ISSN: 0016-6731</identifier><identifier>ISSN: 1943-2631</identifier><identifier>EISSN: 1943-2631</identifier><identifier>DOI: 10.1093/genetics/133.1.87</identifier><identifier>PMID: 8417992</identifier><identifier>CODEN: GENTAE</identifier><language>eng</language><publisher>Bethesda, MD: Genetics Soc America</publisher><subject>ADN ; AILE ; ALAS ; ANEMIAS ; ANIMALS ; ARTHROPODS ; BASIC BIOLOGICAL SCIENCES ; Biological and medical sciences ; BIOLOGICAL MODELS ; Chromatin - metabolism ; CHROMOSOMAL ABERRATIONS ; CHROMOSOME ; Chromosome Mapping ; CHROMOSOMES ; CITOGENETICA ; Classical genetics, quantitative genetics, hybrids ; CROMOSOMAS ; Crosses, Genetic ; CYTOGENETIQUE ; DIPTERA ; DISEASES ; DNA ; DNA-ASE ; DROSOPHILA ; DROSOPHILA MELANOGASTER ; Drosophila melanogaster - drug effects ; Drosophila melanogaster - genetics ; Drosophila melanogaster - physiology ; Drosophila melanogaster - radiation effects ; Embryo, Nonmammalian - metabolism ; ENZYMES ; ESTERASES ; FLIES ; FRUIT FLIES ; Fundamental and applied biological sciences. Psychology ; GENE ; GENE MUTATIONS ; GENES ; Genetics ; Genetics of eukaryotes. Biological and molecular evolution ; HEMIC DISEASES ; Homozygote ; HYDROLASES ; INSECTS ; Invertebrata ; INVERTEBRATES ; Investigations ; LOCI ; LOCOMOCION ; LOCOMOTION ; LOCUS ; MAPPING ; Mechlorethamine - toxicity ; METABOLISM ; MUTACION INDUCIDA ; MUTAGENE ; MUTAGENOS ; Mutagens - toxicity ; MUTANT ; MUTANTES ; Mutation ; MUTATION PROVOQUEE ; MUTATIONS ; NUCLEIC ACIDS ; ORGANIC COMPOUNDS ; Phenotype ; PHOSPHODIESTERASES ; PROTEINS ; Recombination, Genetic ; SYMPTOMS 550400 -- Genetics ; VIABILIDAD ; VIABILITE</subject><ispartof>Genetics (Austin), 1993-01, Vol.133 (1), p.87-96</ispartof><rights>1993 INIST-CNRS</rights><rights>Copyright Genetics Society of America Jan 1993</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c623t-3c783b2f92a793ed2d67b50f29d97546cb10ccdc499864ea149eff7705cbaf6a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4491440$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8417992$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/6199834$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Leonhardt, E.A. (University of California, San Francisco, CA)</creatorcontrib><creatorcontrib>Henderson, D.S</creatorcontrib><creatorcontrib>Rinehart, J.E</creatorcontrib><creatorcontrib>Boyd, J.B</creatorcontrib><title>Characterization of the mus308 gene in Drosophila melanogaster</title><title>Genetics (Austin)</title><addtitle>Genetics</addtitle><description>Among the available mutagen-sensitive mutations in Drosophila, those at the mus308 locus are unique in conferring hypersensitivity to DNA cross-linking agents but not to monofunctional agents. Those mutations are also associated with an elevated frequency of chromosomal aberrations, altered DNA metabolism and the modification of a deoxyribonuclease. This spectrum of phenotypes is shared with selected mammalian mutations including Fanconi anemia in humans. In anticipation of the molecular characterization of the mus308 gene, it has been localized cytogenetically to 87C9-87D1,2 on the right arm of chromosome three. Nine new mutant alleles of the gene have been generated by X-ray mutagenesis and one was recovered following hybrid dysgenesis. Characterization of these new alleles has uncovered additional phenotypes of mutations at this locus. Homozygous mus308 flies that have survived moderate mutagen treatment exhibit an altered wing position that is correlated with reduced flight ability and an altered mitochondria morphology. In addition, observations of elevated embryo mortality are potentially explained by an aberrant distribution of nuclear material in early embryos which is similar to that seen in the mutant giant nuclei</description><subject>ADN</subject><subject>AILE</subject><subject>ALAS</subject><subject>ANEMIAS</subject><subject>ANIMALS</subject><subject>ARTHROPODS</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL MODELS</subject><subject>Chromatin - metabolism</subject><subject>CHROMOSOMAL ABERRATIONS</subject><subject>CHROMOSOME</subject><subject>Chromosome Mapping</subject><subject>CHROMOSOMES</subject><subject>CITOGENETICA</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>CROMOSOMAS</subject><subject>Crosses, Genetic</subject><subject>CYTOGENETIQUE</subject><subject>DIPTERA</subject><subject>DISEASES</subject><subject>DNA</subject><subject>DNA-ASE</subject><subject>DROSOPHILA</subject><subject>DROSOPHILA MELANOGASTER</subject><subject>Drosophila melanogaster - drug effects</subject><subject>Drosophila melanogaster - genetics</subject><subject>Drosophila melanogaster - physiology</subject><subject>Drosophila melanogaster - radiation effects</subject><subject>Embryo, Nonmammalian - metabolism</subject><subject>ENZYMES</subject><subject>ESTERASES</subject><subject>FLIES</subject><subject>FRUIT FLIES</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GENE</subject><subject>GENE MUTATIONS</subject><subject>GENES</subject><subject>Genetics</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>HEMIC DISEASES</subject><subject>Homozygote</subject><subject>HYDROLASES</subject><subject>INSECTS</subject><subject>Invertebrata</subject><subject>INVERTEBRATES</subject><subject>Investigations</subject><subject>LOCI</subject><subject>LOCOMOCION</subject><subject>LOCOMOTION</subject><subject>LOCUS</subject><subject>MAPPING</subject><subject>Mechlorethamine - toxicity</subject><subject>METABOLISM</subject><subject>MUTACION INDUCIDA</subject><subject>MUTAGENE</subject><subject>MUTAGENOS</subject><subject>Mutagens - toxicity</subject><subject>MUTANT</subject><subject>MUTANTES</subject><subject>Mutation</subject><subject>MUTATION PROVOQUEE</subject><subject>MUTATIONS</subject><subject>NUCLEIC ACIDS</subject><subject>ORGANIC COMPOUNDS</subject><subject>Phenotype</subject><subject>PHOSPHODIESTERASES</subject><subject>PROTEINS</subject><subject>Recombination, Genetic</subject><subject>SYMPTOMS 550400 -- Genetics</subject><subject>VIABILIDAD</subject><subject>VIABILITE</subject><issn>0016-6731</issn><issn>1943-2631</issn><issn>1943-2631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkV-P1CAUxYnRrOPqB9DEpDHqW2e5QKG8bGLGv8kmPug-E0ppy6YtI1An-ull0nFcn3g4v3sO9x6EngPeApb0qrezTc7EK6B0C9taPEAbkIyWhFN4iDYYAy-5oPAYPYnxDmPMZVVfoIuagZCSbND1btBBm2SD-62T83PhuyINtpiWSHFdHBMKNxfvg49-P7hRF5Md9ex7HfPQU_So02O0z07vJbr9-OH77nN58_XTl927m9JwQlNJjahpQzpJtJDUtqTloqlwR2QrRcW4aQAb0xomZc2Z1cCk7TohcGUa3XFNL9H16rtfmsm2xs4p6FHtg5t0-KW8dup_ZXaD6v1PBQRXFEM2eLUa-JicisYlawbj59mapDjkXMoy9PaUEvyPxcakJheNHfO-1i9RAa8IkFr-czuDd34Jc76AIsByJlRHN1ghk28Xg-3O3wWsjvWpv_WpXJ8CVYs88_L-nueJU19Zf33SdTR67IKejYtnjDEJjOGMvVmxwfXDwQWr4qTHMZuCOhwO9-JerFynvdJ9yFa33yQltBJA_wBZCbnF</recordid><startdate>199301</startdate><enddate>199301</enddate><creator>Leonhardt, E.A. (University of California, San Francisco, CA)</creator><creator>Henderson, D.S</creator><creator>Rinehart, J.E</creator><creator>Boyd, J.B</creator><general>Genetics Soc America</general><general>Genetics Society of America</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>4T-</scope><scope>4U-</scope><scope>7QP</scope><scope>7SS</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>OTOTI</scope><scope>5PM</scope></search><sort><creationdate>199301</creationdate><title>Characterization of the mus308 gene in Drosophila melanogaster</title><author>Leonhardt, E.A. (University of California, San Francisco, CA) ; Henderson, D.S ; Rinehart, J.E ; Boyd, J.B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c623t-3c783b2f92a793ed2d67b50f29d97546cb10ccdc499864ea149eff7705cbaf6a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>ADN</topic><topic>AILE</topic><topic>ALAS</topic><topic>ANEMIAS</topic><topic>ANIMALS</topic><topic>ARTHROPODS</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL MODELS</topic><topic>Chromatin - metabolism</topic><topic>CHROMOSOMAL ABERRATIONS</topic><topic>CHROMOSOME</topic><topic>Chromosome Mapping</topic><topic>CHROMOSOMES</topic><topic>CITOGENETICA</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>CROMOSOMAS</topic><topic>Crosses, Genetic</topic><topic>CYTOGENETIQUE</topic><topic>DIPTERA</topic><topic>DISEASES</topic><topic>DNA</topic><topic>DNA-ASE</topic><topic>DROSOPHILA</topic><topic>DROSOPHILA MELANOGASTER</topic><topic>Drosophila melanogaster - drug effects</topic><topic>Drosophila melanogaster - genetics</topic><topic>Drosophila melanogaster - physiology</topic><topic>Drosophila melanogaster - radiation effects</topic><topic>Embryo, Nonmammalian - metabolism</topic><topic>ENZYMES</topic><topic>ESTERASES</topic><topic>FLIES</topic><topic>FRUIT FLIES</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GENE</topic><topic>GENE MUTATIONS</topic><topic>GENES</topic><topic>Genetics</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>HEMIC DISEASES</topic><topic>Homozygote</topic><topic>HYDROLASES</topic><topic>INSECTS</topic><topic>Invertebrata</topic><topic>INVERTEBRATES</topic><topic>Investigations</topic><topic>LOCI</topic><topic>LOCOMOCION</topic><topic>LOCOMOTION</topic><topic>LOCUS</topic><topic>MAPPING</topic><topic>Mechlorethamine - toxicity</topic><topic>METABOLISM</topic><topic>MUTACION INDUCIDA</topic><topic>MUTAGENE</topic><topic>MUTAGENOS</topic><topic>Mutagens - toxicity</topic><topic>MUTANT</topic><topic>MUTANTES</topic><topic>Mutation</topic><topic>MUTATION PROVOQUEE</topic><topic>MUTATIONS</topic><topic>NUCLEIC ACIDS</topic><topic>ORGANIC COMPOUNDS</topic><topic>Phenotype</topic><topic>PHOSPHODIESTERASES</topic><topic>PROTEINS</topic><topic>Recombination, Genetic</topic><topic>SYMPTOMS 550400 -- Genetics</topic><topic>VIABILIDAD</topic><topic>VIABILITE</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leonhardt, E.A. 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This spectrum of phenotypes is shared with selected mammalian mutations including Fanconi anemia in humans. In anticipation of the molecular characterization of the mus308 gene, it has been localized cytogenetically to 87C9-87D1,2 on the right arm of chromosome three. Nine new mutant alleles of the gene have been generated by X-ray mutagenesis and one was recovered following hybrid dysgenesis. Characterization of these new alleles has uncovered additional phenotypes of mutations at this locus. Homozygous mus308 flies that have survived moderate mutagen treatment exhibit an altered wing position that is correlated with reduced flight ability and an altered mitochondria morphology. 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| ispartof | Genetics (Austin), 1993-01, Vol.133 (1), p.87-96 |
| issn | 0016-6731 1943-2631 1943-2631 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1205301 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | ADN AILE ALAS ANEMIAS ANIMALS ARTHROPODS BASIC BIOLOGICAL SCIENCES Biological and medical sciences BIOLOGICAL MODELS Chromatin - metabolism CHROMOSOMAL ABERRATIONS CHROMOSOME Chromosome Mapping CHROMOSOMES CITOGENETICA Classical genetics, quantitative genetics, hybrids CROMOSOMAS Crosses, Genetic CYTOGENETIQUE DIPTERA DISEASES DNA DNA-ASE DROSOPHILA DROSOPHILA MELANOGASTER Drosophila melanogaster - drug effects Drosophila melanogaster - genetics Drosophila melanogaster - physiology Drosophila melanogaster - radiation effects Embryo, Nonmammalian - metabolism ENZYMES ESTERASES FLIES FRUIT FLIES Fundamental and applied biological sciences. Psychology GENE GENE MUTATIONS GENES Genetics Genetics of eukaryotes. Biological and molecular evolution HEMIC DISEASES Homozygote HYDROLASES INSECTS Invertebrata INVERTEBRATES Investigations LOCI LOCOMOCION LOCOMOTION LOCUS MAPPING Mechlorethamine - toxicity METABOLISM MUTACION INDUCIDA MUTAGENE MUTAGENOS Mutagens - toxicity MUTANT MUTANTES Mutation MUTATION PROVOQUEE MUTATIONS NUCLEIC ACIDS ORGANIC COMPOUNDS Phenotype PHOSPHODIESTERASES PROTEINS Recombination, Genetic SYMPTOMS 550400 -- Genetics VIABILIDAD VIABILITE |
| title | Characterization of the mus308 gene in Drosophila melanogaster |
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