Sequence analysis of N-ethyl-N-nitrosourea-induced vermilion mutations in Drosophila melanogaster

The mutational specificity of N-ethyl-N-nitrosourea (ENU) was determined in Drosophila melanogaster using the vermilion locus as a target gene. 25 mutants (16 F1 and 9 F2 mutants) were cloned and sequenced. Only base-pair changes were observed; three of the mutants represented double base substituti...

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Veröffentlicht in:	Genetics (Austin) 1989-09, Vol.123 (1), p.123-129
Hauptverfasser:	Pastink, A. (State University of Leiden, Leiden, The Netherlands), Vreeken, C, Nivard, M.J.M, Searles, L.L, Vogel, E.W
Format:	Artikel
Sprache:	eng
Schlagworte:	ADDUCTS AMINES ANIMALS AROMATICS ARTHROPODS AZAARENES AZINES Biological and medical sciences BIOLOGICAL EFFECTS Cloning, Molecular DIPTERA DNA ADDUCTS DNA BASE TRANSITIONS DNA SEQUENCING DNA, Recombinant DROSOPHILA Drosophila melanogaster - genetics Ethylnitrosourea - pharmacology FLIES FRUIT FLIES Fundamental and applied biological sciences. Psychology GENE MUTATIONS GENETIC EFFECTS GENETICA GENETIQUE GUANINE HETEROCYCLIC COMPOUNDS HYDROXY COMPOUNDS INSECTS INVERTEBRATES Investigations Molecular and cellular biology Molecular genetics MUTACION INDUCIDA MUTAGENESIS Mutagenesis. Repair MUTANT MUTANTES Mutation MUTATION PROVOQUEE MUTATIONS NITROSO COMPOUNDS NITROSOUREAS NUCLEOTIDE NUCLEOTIDOS ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS Plasmids Polymorphism, Restriction Fragment Length PURINES PYRIMIDINES RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT Restriction Mapping STRUCTURAL CHEMICAL ANALYSIS THYMINE URACILS 560300 > Chemicals Metabolism & Toxicology
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