Physiological significance of the alcohol dehydrogenase polymorphism in larvae of Drosophila
This study deals with biochemical and metabolic-physiological aspects of the relationship between variation in in vivo alcohol dehydrogenase activity and fitness in larvae homozygous for the alleles Adh71k, AdhF, AdhS, of Drosophila melanogaster, and for the common Adh allele of Drosophila simulans....
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| Veröffentlicht in: | Genetics (Austin) 1987-09, Vol.117 (1), p.75-84 |
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| creator | Heinstra, P.W.H Scharloo, W Thorig, G.E.W |
| description | This study deals with biochemical and metabolic-physiological aspects of the relationship between variation in in vivo alcohol dehydrogenase activity and fitness in larvae homozygous for the alleles Adh71k, AdhF, AdhS, of Drosophila melanogaster, and for the common Adh allele of Drosophila simulans. The Adh genotypes differ in the maximum oxidation rates of propan-2-ol into acetone in vivo. There are smaller differences between the Adh genotypes in rates of ethanol elimination. Rates of accumulation of ethanol in vivo are negatively associated with larval-to-adult survival of the Adh genotypes. The rank order of the maximum rates of the ADHs in elimination of propan-2-ol, as well as ethanol, is ADH-71k greater than ADH-F greater than ADH-S greater than simulans-ADH. The ratio of this maximum rate to ADH quantity reveals the rank order of ADH-S greater than ADH-F greater than ADH-71k greater than simulans-ADH, suggesting a compensation for allozymic efficiency by the ADH quantity in D. melanogaster. Our findings show that natural selection may act on the Adh polymorphism in larvae via differences in rates of alcohol metabolism. |
| doi_str_mv | 10.1093/genetics/117.1.75 |
| format | Article |
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The Adh genotypes differ in the maximum oxidation rates of propan-2-ol into acetone in vivo. There are smaller differences between the Adh genotypes in rates of ethanol elimination. Rates of accumulation of ethanol in vivo are negatively associated with larval-to-adult survival of the Adh genotypes. The rank order of the maximum rates of the ADHs in elimination of propan-2-ol, as well as ethanol, is ADH-71k greater than ADH-F greater than ADH-S greater than simulans-ADH. The ratio of this maximum rate to ADH quantity reveals the rank order of ADH-S greater than ADH-F greater than ADH-71k greater than simulans-ADH, suggesting a compensation for allozymic efficiency by the ADH quantity in D. melanogaster. Our findings show that natural selection may act on the Adh polymorphism in larvae via differences in rates of alcohol metabolism.</description><identifier>ISSN: 0016-6731</identifier><identifier>ISSN: 1943-2631</identifier><identifier>EISSN: 1943-2631</identifier><identifier>DOI: 10.1093/genetics/117.1.75</identifier><identifier>PMID: 3117619</identifier><identifier>CODEN: GENTAE</identifier><language>eng</language><publisher>Bethesda, MD: Genetics Soc America</publisher><subject>ACTIVIDAD ENZIMATICA ; ACTIVITE ENZYMATIQUE ; Alcohol Dehydrogenase - genetics ; Alleles ; Animals ; Biochemistry. Physiology. Immunology ; Biological and medical sciences ; Classical genetics, quantitative genetics, hybrids ; DROSOPHILA ; Drosophila - genetics ; Drosophila - growth & development ; Drosophila melanogaster - genetics ; Drosophila melanogaster - growth & development ; ENZYMIC ACTIVITY ; Fundamental and applied biological sciences. Psychology ; GENE ; GENES ; Genetic Variation ; GENETICA ; GENETICS ; Genetics of eukaryotes. Biological and molecular evolution ; GENETIQUE ; GENOTIPOS ; GENOTYPE ; GENOTYPES ; Insecta ; Invertebrata ; Invertebrates ; Investigations ; Larva ; LARVAE ; LARVAS ; LARVE ; OXIDOREDUCTASES ; OXIDORREDUCTASAS ; OXYDOREDUCTASE ; Physiology. Development ; POLIMORFISMO ; POLYMORPHISM ; Polymorphism, Genetic ; POLYMORPHISME ; Species Specificity</subject><ispartof>Genetics (Austin), 1987-09, Vol.117 (1), p.75-84</ispartof><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-80c8f8368ceb6a0abe3a6ac319e200798d03a2bda02c8bf71b8f6f107f3905f93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7442503$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3117619$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heinstra, P.W.H</creatorcontrib><creatorcontrib>Scharloo, W</creatorcontrib><creatorcontrib>Thorig, G.E.W</creatorcontrib><title>Physiological significance of the alcohol dehydrogenase polymorphism in larvae of Drosophila</title><title>Genetics (Austin)</title><addtitle>Genetics</addtitle><description>This study deals with biochemical and metabolic-physiological aspects of the relationship between variation in in vivo alcohol dehydrogenase activity and fitness in larvae homozygous for the alleles Adh71k, AdhF, AdhS, of Drosophila melanogaster, and for the common Adh allele of Drosophila simulans. The Adh genotypes differ in the maximum oxidation rates of propan-2-ol into acetone in vivo. There are smaller differences between the Adh genotypes in rates of ethanol elimination. Rates of accumulation of ethanol in vivo are negatively associated with larval-to-adult survival of the Adh genotypes. The rank order of the maximum rates of the ADHs in elimination of propan-2-ol, as well as ethanol, is ADH-71k greater than ADH-F greater than ADH-S greater than simulans-ADH. The ratio of this maximum rate to ADH quantity reveals the rank order of ADH-S greater than ADH-F greater than ADH-71k greater than simulans-ADH, suggesting a compensation for allozymic efficiency by the ADH quantity in D. melanogaster. Our findings show that natural selection may act on the Adh polymorphism in larvae via differences in rates of alcohol metabolism.</description><subject>ACTIVIDAD ENZIMATICA</subject><subject>ACTIVITE ENZYMATIQUE</subject><subject>Alcohol Dehydrogenase - genetics</subject><subject>Alleles</subject><subject>Animals</subject><subject>Biochemistry. Physiology. Immunology</subject><subject>Biological and medical sciences</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>DROSOPHILA</subject><subject>Drosophila - genetics</subject><subject>Drosophila - growth & development</subject><subject>Drosophila melanogaster - genetics</subject><subject>Drosophila melanogaster - growth & development</subject><subject>ENZYMIC ACTIVITY</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GENE</subject><subject>GENES</subject><subject>Genetic Variation</subject><subject>GENETICA</subject><subject>GENETICS</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>GENETIQUE</subject><subject>GENOTIPOS</subject><subject>GENOTYPE</subject><subject>GENOTYPES</subject><subject>Insecta</subject><subject>Invertebrata</subject><subject>Invertebrates</subject><subject>Investigations</subject><subject>Larva</subject><subject>LARVAE</subject><subject>LARVAS</subject><subject>LARVE</subject><subject>OXIDOREDUCTASES</subject><subject>OXIDORREDUCTASAS</subject><subject>OXYDOREDUCTASE</subject><subject>Physiology. Development</subject><subject>POLIMORFISMO</subject><subject>POLYMORPHISM</subject><subject>Polymorphism, Genetic</subject><subject>POLYMORPHISME</subject><subject>Species Specificity</subject><issn>0016-6731</issn><issn>1943-2631</issn><issn>1943-2631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUVuL1DAUDqKss6s_QFDog_rW2XOaXtIXQdb1AgsKum9COE2TNpI2Y9LZYf69WWcc1qeEfLeT8zH2AmGN0PLLQc96sSpeIjZrXDfVI7bCtuR5UXN8zFYAWOd1w_EpO4_xFwDUbSXO2BlPghrbFfv5bdxH650frCKXRTvM1qTrrHTmTbaMOiOn_Ohd1utx3wefMinqbOPdfvJhM9o4ZXbOHIU7-qv5EHz06d3RM_bEkIv6-fG8YLcfr39cfc5vvn76cvX-JldVCUsuQAkjeC2U7moC6jSnmhTHVhcATSt64FR0PUGhRGca7ISpDUJjeAuVafkFe3fw3Wy7SfdKz0sgJzfBThT20pOV_yOzHeXg7yQWwFHcG7w9GgT_e6vjIicblXaOZu23UQqEqkFeJCIeiCp9MgZtTiEI8r4S-a8SmTYsUTZV0rx6ON1Jcewg4a-POMXUgQlp-TaeaE1ZFhXwRHtzoI12GHc2aBknci6Zotztdg_iXh54hrykISSr2-9CQFFWIAT_AwHfrzo</recordid><startdate>19870901</startdate><enddate>19870901</enddate><creator>Heinstra, P.W.H</creator><creator>Scharloo, W</creator><creator>Thorig, G.E.W</creator><general>Genetics Soc America</general><general>Genetics Society of America</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19870901</creationdate><title>Physiological significance of the alcohol dehydrogenase polymorphism in larvae of Drosophila</title><author>Heinstra, P.W.H ; Scharloo, W ; Thorig, G.E.W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-80c8f8368ceb6a0abe3a6ac319e200798d03a2bda02c8bf71b8f6f107f3905f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>ACTIVIDAD ENZIMATICA</topic><topic>ACTIVITE ENZYMATIQUE</topic><topic>Alcohol Dehydrogenase - genetics</topic><topic>Alleles</topic><topic>Animals</topic><topic>Biochemistry. Physiology. Immunology</topic><topic>Biological and medical sciences</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>DROSOPHILA</topic><topic>Drosophila - genetics</topic><topic>Drosophila - growth & development</topic><topic>Drosophila melanogaster - genetics</topic><topic>Drosophila melanogaster - growth & development</topic><topic>ENZYMIC ACTIVITY</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GENE</topic><topic>GENES</topic><topic>Genetic Variation</topic><topic>GENETICA</topic><topic>GENETICS</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>GENETIQUE</topic><topic>GENOTIPOS</topic><topic>GENOTYPE</topic><topic>GENOTYPES</topic><topic>Insecta</topic><topic>Invertebrata</topic><topic>Invertebrates</topic><topic>Investigations</topic><topic>Larva</topic><topic>LARVAE</topic><topic>LARVAS</topic><topic>LARVE</topic><topic>OXIDOREDUCTASES</topic><topic>OXIDORREDUCTASAS</topic><topic>OXYDOREDUCTASE</topic><topic>Physiology. Development</topic><topic>POLIMORFISMO</topic><topic>POLYMORPHISM</topic><topic>Polymorphism, Genetic</topic><topic>POLYMORPHISME</topic><topic>Species Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heinstra, P.W.H</creatorcontrib><creatorcontrib>Scharloo, W</creatorcontrib><creatorcontrib>Thorig, G.E.W</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genetics (Austin)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heinstra, P.W.H</au><au>Scharloo, W</au><au>Thorig, G.E.W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physiological significance of the alcohol dehydrogenase polymorphism in larvae of Drosophila</atitle><jtitle>Genetics (Austin)</jtitle><addtitle>Genetics</addtitle><date>1987-09-01</date><risdate>1987</risdate><volume>117</volume><issue>1</issue><spage>75</spage><epage>84</epage><pages>75-84</pages><issn>0016-6731</issn><issn>1943-2631</issn><eissn>1943-2631</eissn><coden>GENTAE</coden><abstract>This study deals with biochemical and metabolic-physiological aspects of the relationship between variation in in vivo alcohol dehydrogenase activity and fitness in larvae homozygous for the alleles Adh71k, AdhF, AdhS, of Drosophila melanogaster, and for the common Adh allele of Drosophila simulans. The Adh genotypes differ in the maximum oxidation rates of propan-2-ol into acetone in vivo. There are smaller differences between the Adh genotypes in rates of ethanol elimination. Rates of accumulation of ethanol in vivo are negatively associated with larval-to-adult survival of the Adh genotypes. The rank order of the maximum rates of the ADHs in elimination of propan-2-ol, as well as ethanol, is ADH-71k greater than ADH-F greater than ADH-S greater than simulans-ADH. The ratio of this maximum rate to ADH quantity reveals the rank order of ADH-S greater than ADH-F greater than ADH-71k greater than simulans-ADH, suggesting a compensation for allozymic efficiency by the ADH quantity in D. melanogaster. Our findings show that natural selection may act on the Adh polymorphism in larvae via differences in rates of alcohol metabolism.</abstract><cop>Bethesda, MD</cop><pub>Genetics Soc America</pub><pmid>3117619</pmid><doi>10.1093/genetics/117.1.75</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Genetics (Austin), 1987-09, Vol.117 (1), p.75-84 |
| issn | 0016-6731 1943-2631 1943-2631 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1203189 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | ACTIVIDAD ENZIMATICA ACTIVITE ENZYMATIQUE Alcohol Dehydrogenase - genetics Alleles Animals Biochemistry. Physiology. Immunology Biological and medical sciences Classical genetics, quantitative genetics, hybrids DROSOPHILA Drosophila - genetics Drosophila - growth & development Drosophila melanogaster - genetics Drosophila melanogaster - growth & development ENZYMIC ACTIVITY Fundamental and applied biological sciences. Psychology GENE GENES Genetic Variation GENETICA GENETICS Genetics of eukaryotes. Biological and molecular evolution GENETIQUE GENOTIPOS GENOTYPE GENOTYPES Insecta Invertebrata Invertebrates Investigations Larva LARVAE LARVAS LARVE OXIDOREDUCTASES OXIDORREDUCTASAS OXYDOREDUCTASE Physiology. Development POLIMORFISMO POLYMORPHISM Polymorphism, Genetic POLYMORPHISME Species Specificity |
| title | Physiological significance of the alcohol dehydrogenase polymorphism in larvae of Drosophila |
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