CELLULAR GENES IN THE MOUSE REGULATE IN TRANS THE EXPRESSION OF ENDOGENOUS MOUSE MAMMARY TUMOR VIRUSES
The transcriptional activities of the eleven mouse mammary tumor virus (MMTV) proviruses endogenous to two sets of recombinant inbred (RI) mouse strains, BXD and BXH, were characterized. Comparison of the levels of virus-specific RNA quantitated in each strain showed no direct relationship between t...
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| Veröffentlicht in: | Genetics (Austin) 1985-11, Vol.111 (3), p.597-615 |
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| container_title | Genetics (Austin) |
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| creator | Traina-Dorge, Vicki L Carr, Jean K Bailey-Wilson, Joan E Elston, Robert C Taylor, Benjamin A Cohen, J. Craig |
| description | The transcriptional activities of the eleven mouse mammary tumor virus (MMTV) proviruses endogenous to two sets of recombinant inbred (RI) mouse strains, BXD and BXH, were characterized. Comparison of the levels of virus-specific RNA quantitated in each strain showed no direct relationship between the presence of a particular endogenous provirus or with increasing numbers of proviruses. Association of specific genetic markers with the level of MMTV-specific RNA was examined by using multiple regression analysis. Several cellular loci as well as proviral loci were identified that were significantly associated with viral expression. Importantly, these cellular loci associated with MMTV expression segregated independently of viral sequences. |
| doi_str_mv | 10.1093/genetics/111.3.597 |
| format | Article |
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Craig</creatorcontrib><title>CELLULAR GENES IN THE MOUSE REGULATE IN TRANS THE EXPRESSION OF ENDOGENOUS MOUSE MAMMARY TUMOR VIRUSES</title><title>Genetics (Austin)</title><addtitle>Genetics</addtitle><description>The transcriptional activities of the eleven mouse mammary tumor virus (MMTV) proviruses endogenous to two sets of recombinant inbred (RI) mouse strains, BXD and BXH, were characterized. Comparison of the levels of virus-specific RNA quantitated in each strain showed no direct relationship between the presence of a particular endogenous provirus or with increasing numbers of proviruses. Association of specific genetic markers with the level of MMTV-specific RNA was examined by using multiple regression analysis. Several cellular loci as well as proviral loci were identified that were significantly associated with viral expression. Importantly, these cellular loci associated with MMTV expression segregated independently of viral sequences.</description><subject>Alleles</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Transformation, Neoplastic</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>Genes, Viral</subject><subject>Investigations</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Mammary Tumor Virus, Mouse - drug effects</subject><subject>Mammary Tumor Virus, Mouse - genetics</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Nucleic Acid Hybridization</subject><subject>Oncogenes</subject><subject>RNA, Viral - genetics</subject><subject>RNA, Viral - isolation & purification</subject><subject>Species Specificity</subject><subject>Transcription, Genetic</subject><issn>0016-6731</issn><issn>1943-2631</issn><issn>1943-2631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUuP0zAUhS0EGsrAH0BC8gKxS8evOPEGKSqeTqU8UNIiWFmO67RBaTLELRX_HjMTOrC60v3OOfdKB4C3GM0xEvRmZ3t7bI27wRjP6TwU0TMww4LRgHCKn4MZQpgHPKL4JXjl3HeEEBdhfAWuiBBcxGQGmoVM002alHApc1nBVQ7XdxJmxaaSsJRLj9byYVsmefXA5NfPpayqVZHD4hbK_FPhrV4_mbIky5LyG1xvsqKEX1alX1avwYtGd86-meY12NzK9eIuSIvlapGkgWGIRkFDQoKNwVFtrA4jTmKMtxyFNWXC8jCODbfM0zriZssEIswio2tdU2GtEJpeg4-Pufen-mC3xvbHUXfqfmwPevylBt2q_0nf7tVu-KkwQYRz5AM-TAHj8ONk3VEdWmds1-neDienMKNRyOLQC8mj0IyDc6NtLkcwUn_aUX_bUb4dRZVvx5ve_fvexTLV4fn7iWtndNeMujetu8hixjlh9OnJfbvbn9vRKnfQXedDsTqfz0_3fgO0_J_r</recordid><startdate>19851101</startdate><enddate>19851101</enddate><creator>Traina-Dorge, Vicki L</creator><creator>Carr, Jean K</creator><creator>Bailey-Wilson, Joan E</creator><creator>Elston, Robert C</creator><creator>Taylor, Benjamin A</creator><creator>Cohen, J. 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Craig</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CELLULAR GENES IN THE MOUSE REGULATE IN TRANS THE EXPRESSION OF ENDOGENOUS MOUSE MAMMARY TUMOR VIRUSES</atitle><jtitle>Genetics (Austin)</jtitle><addtitle>Genetics</addtitle><date>1985-11-01</date><risdate>1985</risdate><volume>111</volume><issue>3</issue><spage>597</spage><epage>615</epage><pages>597-615</pages><issn>0016-6731</issn><issn>1943-2631</issn><eissn>1943-2631</eissn><coden>GENTAE</coden><abstract>The transcriptional activities of the eleven mouse mammary tumor virus (MMTV) proviruses endogenous to two sets of recombinant inbred (RI) mouse strains, BXD and BXH, were characterized. Comparison of the levels of virus-specific RNA quantitated in each strain showed no direct relationship between the presence of a particular endogenous provirus or with increasing numbers of proviruses. Association of specific genetic markers with the level of MMTV-specific RNA was examined by using multiple regression analysis. Several cellular loci as well as proviral loci were identified that were significantly associated with viral expression. Importantly, these cellular loci associated with MMTV expression segregated independently of viral sequences.</abstract><cop>Bethesda, MD</cop><pub>Genetics Soc America</pub><pmid>2996982</pmid><doi>10.1093/genetics/111.3.597</doi><tpages>19</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0016-6731 |
| ispartof | Genetics (Austin), 1985-11, Vol.111 (3), p.597-615 |
| issn | 0016-6731 1943-2631 1943-2631 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1202660 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Alleles Animals Biological and medical sciences Cell Transformation, Neoplastic Female Fundamental and applied biological sciences. Psychology Gene expression Genes, Viral Investigations Lipopolysaccharides - pharmacology Mammary Tumor Virus, Mouse - drug effects Mammary Tumor Virus, Mouse - genetics Mice Mice, Inbred Strains Molecular and cellular biology Molecular genetics Nucleic Acid Hybridization Oncogenes RNA, Viral - genetics RNA, Viral - isolation & purification Species Specificity Transcription, Genetic |
| title | CELLULAR GENES IN THE MOUSE REGULATE IN TRANS THE EXPRESSION OF ENDOGENOUS MOUSE MAMMARY TUMOR VIRUSES |
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