Direct effects of 9-anthracene compounds on cystic fibrosis transmembrane conductance regulator gating

Anthracene-9-carboxylic acid (9-AC) has been reported to show both potentiation and inhibitory effects on guinea-pig cardiac cAMP-activated chloride channels via two different binding sites, and inhibition of Mg(2+)-sensitive protein phosphatases has been proposed for the mechanism of 9-AC potentiat...

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Veröffentlicht in:	Pflügers Archiv 2004-10, Vol.449 (1), p.88-95
Hauptverfasser:	Ai, Tomohiko, Bompadre, Silvia G, Sohma, Yoshiro, Wang, Xiaohui, Li, Min, Hwang, Tzyh-Chang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthracenes - metabolism Anthracenes - pharmacology Binding sites CHO Cells Cricetinae Cystic fibrosis Cystic Fibrosis Transmembrane Conductance Regulator - metabolism Guinea Pigs Humans Ion Channel Gating - drug effects Mice NIH 3T3 Cells Patch-Clamp Techniques Proteins
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