Distribution and fate of cocaine- and amphetamine-regulated transcript peptide (CARTp)-expressing cells in rat urinary bladder: A developmental study
We examined the distribution and fate of cocaine‐ and amphetamine‐regulated transcript peptide (CARTp)55–102‐immunoreactive (IR) structures in the neonatal and adult rat urinary bladder. Double‐labeling studies examining CARTp with tyrosine hydroxylase (TH), neuronal nitric oxide synthase (nNOS), or...
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description | We examined the distribution and fate of cocaine‐ and amphetamine‐regulated transcript peptide (CARTp)55–102‐immunoreactive (IR) structures in the neonatal and adult rat urinary bladder. Double‐labeling studies examining CARTp with tyrosine hydroxylase (TH), neuronal nitric oxide synthase (nNOS), or choline acetyltransferase (ChAT) were performed in wholemounts of urothelium or detrusor or cryostat sections of the bladder. In younger animals (postnatal day [P]1, P3), CARTp‐IR cell bodies in detrusor smooth muscle were observed in large clusters (∼100 cells/cluster) at the ureteral insertion and along thick bundles of nerve fibers at the bladder base. The total number of CARTp‐IR cells was significantly reduced (by five‐fold) at P14, and this reduced number persisted into adulthood. The decrease in the number of CARTp‐expressing cells was complemented with positive staining for cleaved caspase‐3, suggesting that apoptosis contributed to this decrease. At birth (P1), all CARTp‐IR cells expressed the neuronal marker Hu. After birth, CARTp was expressed by some neurons (CARTp‐IR, Hu‐IR) that represent intramural ganglion cells and by cells that lacked a neuronal phenotype (CARTp‐IR, Hu‐) but did express TH. Neither of these cell populations expressed ChAT immunoreactivity in adult bladder. These cells (CARTp‐IR, Hu‐, TH‐IR) may represent paraganglion or small intensely fluorescent (SIF) cells. The percentage of colocalization of CARTp‐IR and nNOS or TH was dependent on postnatal age and showed an inverse relationship. At P1, 67.1 % of CARTp‐IR cells expressed nNOS immunoreactivity. Decreased colocalization was observed with increasing postnatal age. In contrast, 19.5% of CARTp‐IR cells expressed TH at P1, but colocalization increased with postnatal age. The suburothelial plexus lacked CARTp‐IR nerve fibers until P14, when nerve fibers with varicosities were observed in the urethra and bladder neck region. In summary, we demonstrate 1) a decrease in the number of CARTp‐IR cells in rat detrusor in early postnatal development; 2) apoptotic events in the bladder during early postnatal development; 3) rostral migration of CARTp‐IR cells from the ureteral insertion toward the bladder body during postnatal development; 4) the presence of different populations of CARTp‐IR cells, some with and others without a neuronal phenotype; and (5) age‐dependent changes in chemical coding of CARTp‐IR cells with postnatal development. This study demonstrates that CARTp‐IR intramur |
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Double‐labeling studies examining CARTp with tyrosine hydroxylase (TH), neuronal nitric oxide synthase (nNOS), or choline acetyltransferase (ChAT) were performed in wholemounts of urothelium or detrusor or cryostat sections of the bladder. In younger animals (postnatal day [P]1, P3), CARTp‐IR cell bodies in detrusor smooth muscle were observed in large clusters (∼100 cells/cluster) at the ureteral insertion and along thick bundles of nerve fibers at the bladder base. The total number of CARTp‐IR cells was significantly reduced (by five‐fold) at P14, and this reduced number persisted into adulthood. The decrease in the number of CARTp‐expressing cells was complemented with positive staining for cleaved caspase‐3, suggesting that apoptosis contributed to this decrease. At birth (P1), all CARTp‐IR cells expressed the neuronal marker Hu. After birth, CARTp was expressed by some neurons (CARTp‐IR, Hu‐IR) that represent intramural ganglion cells and by cells that lacked a neuronal phenotype (CARTp‐IR, Hu‐) but did express TH. Neither of these cell populations expressed ChAT immunoreactivity in adult bladder. These cells (CARTp‐IR, Hu‐, TH‐IR) may represent paraganglion or small intensely fluorescent (SIF) cells. The percentage of colocalization of CARTp‐IR and nNOS or TH was dependent on postnatal age and showed an inverse relationship. At P1, 67.1 % of CARTp‐IR cells expressed nNOS immunoreactivity. Decreased colocalization was observed with increasing postnatal age. In contrast, 19.5% of CARTp‐IR cells expressed TH at P1, but colocalization increased with postnatal age. The suburothelial plexus lacked CARTp‐IR nerve fibers until P14, when nerve fibers with varicosities were observed in the urethra and bladder neck region. In summary, we demonstrate 1) a decrease in the number of CARTp‐IR cells in rat detrusor in early postnatal development; 2) apoptotic events in the bladder during early postnatal development; 3) rostral migration of CARTp‐IR cells from the ureteral insertion toward the bladder body during postnatal development; 4) the presence of different populations of CARTp‐IR cells, some with and others without a neuronal phenotype; and (5) age‐dependent changes in chemical coding of CARTp‐IR cells with postnatal development. This study demonstrates that CARTp‐IR intramural ganglia and CARTp‐IR paraganglion or SIF cells exist in the postnatal and adult rat bladder, although the role of these cell types remains to be determined. J. Comp. Neurol. 489:501–517, 2005. © 2005 Wiley‐Liss, Inc.</description><identifier>ISSN: 0021-9967</identifier><identifier>EISSN: 1096-9861</identifier><identifier>DOI: 10.1002/cne.20657</identifier><identifier>PMID: 16025456</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aging - metabolism ; Animals ; Animals, Newborn ; apoptosis ; Apoptosis - physiology ; Autonomic Pathways - cytology ; Autonomic Pathways - metabolism ; Caspase 3 ; Caspases - metabolism ; Cell Count ; Cell Differentiation - physiology ; Choline O-Acetyltransferase - metabolism ; ELAV Proteins ; Female ; Ganglia, Autonomic - cytology ; Ganglia, Autonomic - growth & development ; Ganglia, Autonomic - metabolism ; Immunohistochemistry ; intramural ganglia ; Male ; Muscle, Smooth - cytology ; Muscle, Smooth - metabolism ; Nerve Endings - growth & development ; Nerve Endings - metabolism ; Nerve Endings - ultrastructure ; Nerve Tissue Proteins - metabolism ; Nitric Oxide Synthase - metabolism ; nNOS ; postnatal development ; Rats ; Rats, Wistar ; RNA-Binding Proteins - metabolism ; SIF cells ; Tyrosine 3-Monooxygenase - metabolism ; Urinary Bladder - cytology ; Urinary Bladder - growth & development ; Urinary Bladder - innervation ; Urothelium - cytology ; Urothelium - metabolism</subject><ispartof>Journal of comparative neurology (1911), 2005-09, Vol.489 (4), p.501-517</ispartof><rights>Copyright © 2005 Wiley‐Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4827-e52d8235706332bfd080f4a98e71ef79d6b6bee8b50bf491c1ff89a917161f323</citedby><cites>FETCH-LOGICAL-c4827-e52d8235706332bfd080f4a98e71ef79d6b6bee8b50bf491c1ff89a917161f323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcne.20657$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcne.20657$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16025456$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zvarova, Katarina</creatorcontrib><creatorcontrib>Vizzard, Margaret A.</creatorcontrib><title>Distribution and fate of cocaine- and amphetamine-regulated transcript peptide (CARTp)-expressing cells in rat urinary bladder: A developmental study</title><title>Journal of comparative neurology (1911)</title><addtitle>J. Comp. Neurol</addtitle><description>We examined the distribution and fate of cocaine‐ and amphetamine‐regulated transcript peptide (CARTp)55–102‐immunoreactive (IR) structures in the neonatal and adult rat urinary bladder. Double‐labeling studies examining CARTp with tyrosine hydroxylase (TH), neuronal nitric oxide synthase (nNOS), or choline acetyltransferase (ChAT) were performed in wholemounts of urothelium or detrusor or cryostat sections of the bladder. In younger animals (postnatal day [P]1, P3), CARTp‐IR cell bodies in detrusor smooth muscle were observed in large clusters (∼100 cells/cluster) at the ureteral insertion and along thick bundles of nerve fibers at the bladder base. The total number of CARTp‐IR cells was significantly reduced (by five‐fold) at P14, and this reduced number persisted into adulthood. The decrease in the number of CARTp‐expressing cells was complemented with positive staining for cleaved caspase‐3, suggesting that apoptosis contributed to this decrease. At birth (P1), all CARTp‐IR cells expressed the neuronal marker Hu. After birth, CARTp was expressed by some neurons (CARTp‐IR, Hu‐IR) that represent intramural ganglion cells and by cells that lacked a neuronal phenotype (CARTp‐IR, Hu‐) but did express TH. Neither of these cell populations expressed ChAT immunoreactivity in adult bladder. These cells (CARTp‐IR, Hu‐, TH‐IR) may represent paraganglion or small intensely fluorescent (SIF) cells. The percentage of colocalization of CARTp‐IR and nNOS or TH was dependent on postnatal age and showed an inverse relationship. At P1, 67.1 % of CARTp‐IR cells expressed nNOS immunoreactivity. Decreased colocalization was observed with increasing postnatal age. In contrast, 19.5% of CARTp‐IR cells expressed TH at P1, but colocalization increased with postnatal age. The suburothelial plexus lacked CARTp‐IR nerve fibers until P14, when nerve fibers with varicosities were observed in the urethra and bladder neck region. In summary, we demonstrate 1) a decrease in the number of CARTp‐IR cells in rat detrusor in early postnatal development; 2) apoptotic events in the bladder during early postnatal development; 3) rostral migration of CARTp‐IR cells from the ureteral insertion toward the bladder body during postnatal development; 4) the presence of different populations of CARTp‐IR cells, some with and others without a neuronal phenotype; and (5) age‐dependent changes in chemical coding of CARTp‐IR cells with postnatal development. This study demonstrates that CARTp‐IR intramural ganglia and CARTp‐IR paraganglion or SIF cells exist in the postnatal and adult rat bladder, although the role of these cell types remains to be determined. J. Comp. Neurol. 489:501–517, 2005. © 2005 Wiley‐Liss, Inc.</description><subject>Aging - metabolism</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>apoptosis</subject><subject>Apoptosis - physiology</subject><subject>Autonomic Pathways - cytology</subject><subject>Autonomic Pathways - metabolism</subject><subject>Caspase 3</subject><subject>Caspases - metabolism</subject><subject>Cell Count</subject><subject>Cell Differentiation - physiology</subject><subject>Choline O-Acetyltransferase - metabolism</subject><subject>ELAV Proteins</subject><subject>Female</subject><subject>Ganglia, Autonomic - cytology</subject><subject>Ganglia, Autonomic - growth & development</subject><subject>Ganglia, Autonomic - metabolism</subject><subject>Immunohistochemistry</subject><subject>intramural ganglia</subject><subject>Male</subject><subject>Muscle, Smooth - cytology</subject><subject>Muscle, Smooth - metabolism</subject><subject>Nerve Endings - growth & development</subject><subject>Nerve Endings - metabolism</subject><subject>Nerve Endings - ultrastructure</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Nitric Oxide Synthase - metabolism</subject><subject>nNOS</subject><subject>postnatal development</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>RNA-Binding Proteins - metabolism</subject><subject>SIF cells</subject><subject>Tyrosine 3-Monooxygenase - metabolism</subject><subject>Urinary Bladder - cytology</subject><subject>Urinary Bladder - growth & development</subject><subject>Urinary Bladder - innervation</subject><subject>Urothelium - cytology</subject><subject>Urothelium - metabolism</subject><issn>0021-9967</issn><issn>1096-9861</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkstuFDEQRS0EIkNgwQ8grxBZdGL3ww8WSMMkBKRRkGAQS8vdLk8M3e7GdofMh_C_9DwIsECsSqo6dXVLtxB6SskpJSQ_azyc5oRV_B6aUSJZJgWj99FsmtFMSsaP0KMYvxBCpCzEQ3REGcmrsmIz9OPcxRRcPSbXe6y9wVYnwL3FTd9o5yHbNXU3XEPS3bYRYD22E2RwCtrHJrgh4QGG5AzgF4v5h9VwksHtECBG59e4gbaN2HkcdMJjcF6HDa5bbQyEl3iODdxA2w8d-KRbHNNoNo_RA6vbCE8O9Rh9enOxWrzNlu8v3y3my6wpRc4zqHIj8qLihBVFXltDBLGllgI4BculYTWrAURdkdqWkjbUWiG1pJwyaou8OEav9rrDWHdgmslC0K0agusmk6rXTv098e5arfsbRXNCy2or8PwgEPpvI8SkOhe3B2sP_RgVE4QTIar_gpRPF-Q78GQPNqGPMYC9c0OJ2qatprTVLu2Jffan_d_kId4JONsD310Lm38rqcXVxS_JbL8xvQXc3m3o8FUxXvBKfb66VCv-kb0-F0tVFD8Bl3jGSQ</recordid><startdate>20050905</startdate><enddate>20050905</enddate><creator>Zvarova, Katarina</creator><creator>Vizzard, Margaret A.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20050905</creationdate><title>Distribution and fate of cocaine- and amphetamine-regulated transcript peptide (CARTp)-expressing cells in rat urinary bladder: A developmental study</title><author>Zvarova, Katarina ; Vizzard, Margaret A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4827-e52d8235706332bfd080f4a98e71ef79d6b6bee8b50bf491c1ff89a917161f323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aging - metabolism</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>apoptosis</topic><topic>Apoptosis - physiology</topic><topic>Autonomic Pathways - cytology</topic><topic>Autonomic Pathways - metabolism</topic><topic>Caspase 3</topic><topic>Caspases - metabolism</topic><topic>Cell Count</topic><topic>Cell Differentiation - physiology</topic><topic>Choline O-Acetyltransferase - metabolism</topic><topic>ELAV Proteins</topic><topic>Female</topic><topic>Ganglia, Autonomic - cytology</topic><topic>Ganglia, Autonomic - growth & development</topic><topic>Ganglia, Autonomic - metabolism</topic><topic>Immunohistochemistry</topic><topic>intramural ganglia</topic><topic>Male</topic><topic>Muscle, Smooth - cytology</topic><topic>Muscle, Smooth - metabolism</topic><topic>Nerve Endings - growth & development</topic><topic>Nerve Endings - metabolism</topic><topic>Nerve Endings - ultrastructure</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Nitric Oxide Synthase - metabolism</topic><topic>nNOS</topic><topic>postnatal development</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>RNA-Binding Proteins - metabolism</topic><topic>SIF cells</topic><topic>Tyrosine 3-Monooxygenase - metabolism</topic><topic>Urinary Bladder - cytology</topic><topic>Urinary Bladder - growth & development</topic><topic>Urinary Bladder - innervation</topic><topic>Urothelium - cytology</topic><topic>Urothelium - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zvarova, Katarina</creatorcontrib><creatorcontrib>Vizzard, Margaret A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of comparative neurology (1911)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zvarova, Katarina</au><au>Vizzard, Margaret A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution and fate of cocaine- and amphetamine-regulated transcript peptide (CARTp)-expressing cells in rat urinary bladder: A developmental study</atitle><jtitle>Journal of comparative neurology (1911)</jtitle><addtitle>J. Comp. Neurol</addtitle><date>2005-09-05</date><risdate>2005</risdate><volume>489</volume><issue>4</issue><spage>501</spage><epage>517</epage><pages>501-517</pages><issn>0021-9967</issn><eissn>1096-9861</eissn><abstract>We examined the distribution and fate of cocaine‐ and amphetamine‐regulated transcript peptide (CARTp)55–102‐immunoreactive (IR) structures in the neonatal and adult rat urinary bladder. Double‐labeling studies examining CARTp with tyrosine hydroxylase (TH), neuronal nitric oxide synthase (nNOS), or choline acetyltransferase (ChAT) were performed in wholemounts of urothelium or detrusor or cryostat sections of the bladder. In younger animals (postnatal day [P]1, P3), CARTp‐IR cell bodies in detrusor smooth muscle were observed in large clusters (∼100 cells/cluster) at the ureteral insertion and along thick bundles of nerve fibers at the bladder base. The total number of CARTp‐IR cells was significantly reduced (by five‐fold) at P14, and this reduced number persisted into adulthood. The decrease in the number of CARTp‐expressing cells was complemented with positive staining for cleaved caspase‐3, suggesting that apoptosis contributed to this decrease. At birth (P1), all CARTp‐IR cells expressed the neuronal marker Hu. After birth, CARTp was expressed by some neurons (CARTp‐IR, Hu‐IR) that represent intramural ganglion cells and by cells that lacked a neuronal phenotype (CARTp‐IR, Hu‐) but did express TH. Neither of these cell populations expressed ChAT immunoreactivity in adult bladder. These cells (CARTp‐IR, Hu‐, TH‐IR) may represent paraganglion or small intensely fluorescent (SIF) cells. The percentage of colocalization of CARTp‐IR and nNOS or TH was dependent on postnatal age and showed an inverse relationship. At P1, 67.1 % of CARTp‐IR cells expressed nNOS immunoreactivity. Decreased colocalization was observed with increasing postnatal age. In contrast, 19.5% of CARTp‐IR cells expressed TH at P1, but colocalization increased with postnatal age. The suburothelial plexus lacked CARTp‐IR nerve fibers until P14, when nerve fibers with varicosities were observed in the urethra and bladder neck region. In summary, we demonstrate 1) a decrease in the number of CARTp‐IR cells in rat detrusor in early postnatal development; 2) apoptotic events in the bladder during early postnatal development; 3) rostral migration of CARTp‐IR cells from the ureteral insertion toward the bladder body during postnatal development; 4) the presence of different populations of CARTp‐IR cells, some with and others without a neuronal phenotype; and (5) age‐dependent changes in chemical coding of CARTp‐IR cells with postnatal development. This study demonstrates that CARTp‐IR intramural ganglia and CARTp‐IR paraganglion or SIF cells exist in the postnatal and adult rat bladder, although the role of these cell types remains to be determined. J. Comp. Neurol. 489:501–517, 2005. © 2005 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>16025456</pmid><doi>10.1002/cne.20657</doi><tpages>17</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Aging - metabolism Animals Animals, Newborn apoptosis Apoptosis - physiology Autonomic Pathways - cytology Autonomic Pathways - metabolism Caspase 3 Caspases - metabolism Cell Count Cell Differentiation - physiology Choline O-Acetyltransferase - metabolism ELAV Proteins Female Ganglia, Autonomic - cytology Ganglia, Autonomic - growth & development Ganglia, Autonomic - metabolism Immunohistochemistry intramural ganglia Male Muscle, Smooth - cytology Muscle, Smooth - metabolism Nerve Endings - growth & development Nerve Endings - metabolism Nerve Endings - ultrastructure Nerve Tissue Proteins - metabolism Nitric Oxide Synthase - metabolism nNOS postnatal development Rats Rats, Wistar RNA-Binding Proteins - metabolism SIF cells Tyrosine 3-Monooxygenase - metabolism Urinary Bladder - cytology Urinary Bladder - growth & development Urinary Bladder - innervation Urothelium - cytology Urothelium - metabolism |
title | Distribution and fate of cocaine- and amphetamine-regulated transcript peptide (CARTp)-expressing cells in rat urinary bladder: A developmental study |
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