Single-Gene Disorders: What Role Could Moonlighting Enzymes Play?

Single-gene disorders with “simple” Mendelian inheritance do not always imply that there will be an easy prediction of the phenotype from the genotype, which has been shown for a number of metabolic disorders. We propose that moonlighting enzymes (i.e., metabolic enzymes with additional functional a...

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Veröffentlicht in:	American journal of human genetics 2005-06, Vol.76 (6), p.911-924
Hauptverfasser:	Sriram, Ganesh, Martinez, Julian A., McCabe, Edward R.B., Liao, James C., Dipple, Katrina M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anatomy & physiology Animals Apoptosis Biological and medical sciences Disease Enzymes Gene Expression Regulation General aspects. Genetic counseling Genetic Diseases, Inborn - enzymology Genetic Diseases, Inborn - metabolism Genotype & phenotype Humans Medical genetics Medical sciences Molecular Biology - methods Multienzyme Complexes - chemistry Multienzyme Complexes - genetics Multienzyme Complexes - metabolism Proteins Proteins - chemistry Proteins - genetics Proteins - metabolism Review Signal Transduction Structure-Activity Relationship Transcription, Genetic
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