Regression Mapping of Association between the Human Leukocyte Antigen Region and Graves Disease

The human leukocyte antigen class II genes DRB1, DQB1, and DQA1 are associated with Graves disease (GD), but, because of strong linkage disequilibrium within this region, the primary etiological variant(s) remains unknown. In the present study, 871 patients with GD and 621 control subjects were geno...

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Veröffentlicht in:	American journal of human genetics 2005-01, Vol.76 (1), p.157-163
Hauptverfasser:	Simmonds, Matthew J., Howson, Joanna M.M., Heward, Joanne M., Cordell, Heather J., Foxall, Helen, Carr-Smith, Jackie, Gibson, Sarah M., Walker, Neil, Tomer, Yaron, Franklyn, Jayne A., Todd, John A., Gough, Stephen C.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Autoimmune diseases Biological and medical sciences Case-Control Studies Chromosome Mapping Endocrinopathies Gene expression General aspects. Genetic counseling Genes, MHC Class II Genomics Genotype Graves Disease - genetics Histocompatibility Antigens Class II HLA-DQ alpha-Chains HLA-DQ Antigens - genetics HLA-DQ beta-Chains HLA-DR Antigens - genetics Humans Immune system Leukocytes Medical genetics Medical sciences Non tumoral diseases. Target tissue resistance. Benign neoplasms Odds Ratio Polymorphism, Genetic Regression Analysis Thyroid. Thyroid axis (diseases)
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