Intermittent prophylactic treatment of recurrent vaginal candidiasis by postmenstrual application of a 500 mg clotrimazole vaginal tablet
The therapeutic efficacy of intermittent, monthly, postmenstrual prophylaxis with a single 500 mg clotrimazole vaginal tablet (n = 33) was compared with placebo tablets (n = 29) in 62 woman (age 28.1, SD 7.2 years) with recurrent vulvovaginal candidiasis. The number of episodes of acute vulvovaginal...
Gespeichert in:
| Veröffentlicht in: | Genitourinary Medicine 1990-10, Vol.66 (5), p.357-360 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 360 |
|---|---|
| container_issue | 5 |
| container_start_page | 357 |
| container_title | Genitourinary Medicine |
| container_volume | 66 |
| creator | Roth, A C Milsom, I Forssman, L Wåhlén, P |
| description | The therapeutic efficacy of intermittent, monthly, postmenstrual prophylaxis with a single 500 mg clotrimazole vaginal tablet (n = 33) was compared with placebo tablets (n = 29) in 62 woman (age 28.1, SD 7.2 years) with recurrent vulvovaginal candidiasis. The number of episodes of acute vulvovaginal candidiasis experienced during the year prior to inclusion was 6.3, SD 1.9. The cumulative recurrence frequency after 6 months intermittent prophylaxis with clotrimazole (30.3%) was lower (p less than 0.001) than that recorded for the women who received placebo (79.3%). After an additional 6 months observation period without treatment there was no significant difference in the cumulative recurrence frequency between the groups (clotrimazole 84.9%; placebo 86.2%). The vagina was recolonised with Candida albicans in 70% of the women after 6 months prophylactic treatment with clotrimazole and in 86% of the women who had received placebo. Thus, this study has demonstrated that postmenstrual prophylactic treatment with a single 500 mg clotrimazole vaginal tablet, applied monthly, prevents recurrence of symptoms, although it does not eliminate yeasts from the vagina. |
| doi_str_mv | 10.1136/sti.66.5.357 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1194557</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3973172891</sourcerecordid><originalsourceid>FETCH-LOGICAL-b581t-93338fd59a8fee7ca0e5f75df60194ed1b9fc3bdd4e59b185b3669a407a34fd83</originalsourceid><addsrcrecordid>eNqFkk-P1CAYxhujWcfVm1eTJka92BFKgXIxMRPdXTNZPahX8pbSWUZaKtCN4zfwWy_dmYx_DnqBwPPjyfPyvln2GKMlxoS9CtEsGVvSJaH8TrbAFS8LUjJyN1ugkrGiIlV9P3sQwhYhxDgVJ9lJWVZU1GSR_bwYova9iVEPMR-9G692FlQ0Ko9eQ-zna9flXqvJ-_lwDRszgM0VDK1pDQQT8maXjy7McIh-SiKMozUKonHD_BpyilDeb3JlXfSmhx_O6qNThMbq-DC714EN-tFhP80-v3v7aXVerD-cXazerIuG1jgWghBSdy0VUHdacwVI047TtmMIi0q3uBGdIk3bVpqKBte0IYwJqBAHUnVtTU6z13vfcWp63apUkwcrxzmW30kHRv6pDOZKbty1xMmfUp4Mnh8MvPs26RBlb4LS1sKg3RRkjXApmED_BTGb-yHmSE__Ardu8ulrEsM5RgSTarZ7uaeUdyF43R0zYyTnSZBpEiRjkkpyG_PJ73Ue4UPrk_7soENQYDsPgzLhl6cgiNMSJ67YcyZE_f2og_8qGSecyssvqxTz8uM6LfJ94l_s-abf_jvhDeij2-0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1771031340</pqid></control><display><type>article</type><title>Intermittent prophylactic treatment of recurrent vaginal candidiasis by postmenstrual application of a 500 mg clotrimazole vaginal tablet</title><source>MEDLINE</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Roth, A C ; Milsom, I ; Forssman, L ; Wåhlén, P</creator><creatorcontrib>Roth, A C ; Milsom, I ; Forssman, L ; Wåhlén, P</creatorcontrib><description>The therapeutic efficacy of intermittent, monthly, postmenstrual prophylaxis with a single 500 mg clotrimazole vaginal tablet (n = 33) was compared with placebo tablets (n = 29) in 62 woman (age 28.1, SD 7.2 years) with recurrent vulvovaginal candidiasis. The number of episodes of acute vulvovaginal candidiasis experienced during the year prior to inclusion was 6.3, SD 1.9. The cumulative recurrence frequency after 6 months intermittent prophylaxis with clotrimazole (30.3%) was lower (p less than 0.001) than that recorded for the women who received placebo (79.3%). After an additional 6 months observation period without treatment there was no significant difference in the cumulative recurrence frequency between the groups (clotrimazole 84.9%; placebo 86.2%). The vagina was recolonised with Candida albicans in 70% of the women after 6 months prophylactic treatment with clotrimazole and in 86% of the women who had received placebo. Thus, this study has demonstrated that postmenstrual prophylactic treatment with a single 500 mg clotrimazole vaginal tablet, applied monthly, prevents recurrence of symptoms, although it does not eliminate yeasts from the vagina.</description><identifier>ISSN: 0266-4348</identifier><identifier>ISSN: 1368-4973</identifier><identifier>EISSN: 1472-3263</identifier><identifier>DOI: 10.1136/sti.66.5.357</identifier><identifier>PMID: 2245983</identifier><identifier>CODEN: GEMEE2</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>Administration, Intravaginal ; Adult ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antifungal agents ; Biological and medical sciences ; Candidiasis, Vulvovaginal - microbiology ; Candidiasis, Vulvovaginal - prevention & control ; Clotrimazole - administration & dosage ; Colony Count, Microbial ; Double-Blind Method ; Drug Administration Schedule ; Female ; Humans ; Medical sciences ; Menstruation ; Pharmacology. Drug treatments ; Recurrence ; Vagina - microbiology</subject><ispartof>Genitourinary Medicine, 1990-10, Vol.66 (5), p.357-360</ispartof><rights>1991 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Oct 1990</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b581t-93338fd59a8fee7ca0e5f75df60194ed1b9fc3bdd4e59b185b3669a407a34fd83</citedby><cites>FETCH-LOGICAL-b581t-93338fd59a8fee7ca0e5f75df60194ed1b9fc3bdd4e59b185b3669a407a34fd83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1194557/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1194557/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19307521$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2245983$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roth, A C</creatorcontrib><creatorcontrib>Milsom, I</creatorcontrib><creatorcontrib>Forssman, L</creatorcontrib><creatorcontrib>Wåhlén, P</creatorcontrib><title>Intermittent prophylactic treatment of recurrent vaginal candidiasis by postmenstrual application of a 500 mg clotrimazole vaginal tablet</title><title>Genitourinary Medicine</title><addtitle>Genitourin Med</addtitle><description>The therapeutic efficacy of intermittent, monthly, postmenstrual prophylaxis with a single 500 mg clotrimazole vaginal tablet (n = 33) was compared with placebo tablets (n = 29) in 62 woman (age 28.1, SD 7.2 years) with recurrent vulvovaginal candidiasis. The number of episodes of acute vulvovaginal candidiasis experienced during the year prior to inclusion was 6.3, SD 1.9. The cumulative recurrence frequency after 6 months intermittent prophylaxis with clotrimazole (30.3%) was lower (p less than 0.001) than that recorded for the women who received placebo (79.3%). After an additional 6 months observation period without treatment there was no significant difference in the cumulative recurrence frequency between the groups (clotrimazole 84.9%; placebo 86.2%). The vagina was recolonised with Candida albicans in 70% of the women after 6 months prophylactic treatment with clotrimazole and in 86% of the women who had received placebo. Thus, this study has demonstrated that postmenstrual prophylactic treatment with a single 500 mg clotrimazole vaginal tablet, applied monthly, prevents recurrence of symptoms, although it does not eliminate yeasts from the vagina.</description><subject>Administration, Intravaginal</subject><subject>Adult</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antifungal agents</subject><subject>Biological and medical sciences</subject><subject>Candidiasis, Vulvovaginal - microbiology</subject><subject>Candidiasis, Vulvovaginal - prevention & control</subject><subject>Clotrimazole - administration & dosage</subject><subject>Colony Count, Microbial</subject><subject>Double-Blind Method</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Menstruation</subject><subject>Pharmacology. Drug treatments</subject><subject>Recurrence</subject><subject>Vagina - microbiology</subject><issn>0266-4348</issn><issn>1368-4973</issn><issn>1472-3263</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkk-P1CAYxhujWcfVm1eTJka92BFKgXIxMRPdXTNZPahX8pbSWUZaKtCN4zfwWy_dmYx_DnqBwPPjyfPyvln2GKMlxoS9CtEsGVvSJaH8TrbAFS8LUjJyN1ugkrGiIlV9P3sQwhYhxDgVJ9lJWVZU1GSR_bwYova9iVEPMR-9G692FlQ0Ko9eQ-zna9flXqvJ-_lwDRszgM0VDK1pDQQT8maXjy7McIh-SiKMozUKonHD_BpyilDeb3JlXfSmhx_O6qNThMbq-DC714EN-tFhP80-v3v7aXVerD-cXazerIuG1jgWghBSdy0VUHdacwVI047TtmMIi0q3uBGdIk3bVpqKBte0IYwJqBAHUnVtTU6z13vfcWp63apUkwcrxzmW30kHRv6pDOZKbty1xMmfUp4Mnh8MvPs26RBlb4LS1sKg3RRkjXApmED_BTGb-yHmSE__Ardu8ulrEsM5RgSTarZ7uaeUdyF43R0zYyTnSZBpEiRjkkpyG_PJ73Ue4UPrk_7soENQYDsPgzLhl6cgiNMSJ67YcyZE_f2og_8qGSecyssvqxTz8uM6LfJ94l_s-abf_jvhDeij2-0</recordid><startdate>19901001</startdate><enddate>19901001</enddate><creator>Roth, A C</creator><creator>Milsom, I</creator><creator>Forssman, L</creator><creator>Wåhlén, P</creator><general>BMJ Publishing Group Ltd</general><general>British Medical Association</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>M7N</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19901001</creationdate><title>Intermittent prophylactic treatment of recurrent vaginal candidiasis by postmenstrual application of a 500 mg clotrimazole vaginal tablet</title><author>Roth, A C ; Milsom, I ; Forssman, L ; Wåhlén, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b581t-93338fd59a8fee7ca0e5f75df60194ed1b9fc3bdd4e59b185b3669a407a34fd83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Administration, Intravaginal</topic><topic>Adult</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antifungal agents</topic><topic>Biological and medical sciences</topic><topic>Candidiasis, Vulvovaginal - microbiology</topic><topic>Candidiasis, Vulvovaginal - prevention & control</topic><topic>Clotrimazole - administration & dosage</topic><topic>Colony Count, Microbial</topic><topic>Double-Blind Method</topic><topic>Drug Administration Schedule</topic><topic>Female</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Menstruation</topic><topic>Pharmacology. Drug treatments</topic><topic>Recurrence</topic><topic>Vagina - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roth, A C</creatorcontrib><creatorcontrib>Milsom, I</creatorcontrib><creatorcontrib>Forssman, L</creatorcontrib><creatorcontrib>Wåhlén, P</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genitourinary Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roth, A C</au><au>Milsom, I</au><au>Forssman, L</au><au>Wåhlén, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intermittent prophylactic treatment of recurrent vaginal candidiasis by postmenstrual application of a 500 mg clotrimazole vaginal tablet</atitle><jtitle>Genitourinary Medicine</jtitle><addtitle>Genitourin Med</addtitle><date>1990-10-01</date><risdate>1990</risdate><volume>66</volume><issue>5</issue><spage>357</spage><epage>360</epage><pages>357-360</pages><issn>0266-4348</issn><issn>1368-4973</issn><eissn>1472-3263</eissn><coden>GEMEE2</coden><abstract>The therapeutic efficacy of intermittent, monthly, postmenstrual prophylaxis with a single 500 mg clotrimazole vaginal tablet (n = 33) was compared with placebo tablets (n = 29) in 62 woman (age 28.1, SD 7.2 years) with recurrent vulvovaginal candidiasis. The number of episodes of acute vulvovaginal candidiasis experienced during the year prior to inclusion was 6.3, SD 1.9. The cumulative recurrence frequency after 6 months intermittent prophylaxis with clotrimazole (30.3%) was lower (p less than 0.001) than that recorded for the women who received placebo (79.3%). After an additional 6 months observation period without treatment there was no significant difference in the cumulative recurrence frequency between the groups (clotrimazole 84.9%; placebo 86.2%). The vagina was recolonised with Candida albicans in 70% of the women after 6 months prophylactic treatment with clotrimazole and in 86% of the women who had received placebo. Thus, this study has demonstrated that postmenstrual prophylactic treatment with a single 500 mg clotrimazole vaginal tablet, applied monthly, prevents recurrence of symptoms, although it does not eliminate yeasts from the vagina.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd</pub><pmid>2245983</pmid><doi>10.1136/sti.66.5.357</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0266-4348 |
| ispartof | Genitourinary Medicine, 1990-10, Vol.66 (5), p.357-360 |
| issn | 0266-4348 1368-4973 1472-3263 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1194557 |
| source | MEDLINE; PubMed Central; Alma/SFX Local Collection |
| subjects | Administration, Intravaginal Adult Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Biological and medical sciences Candidiasis, Vulvovaginal - microbiology Candidiasis, Vulvovaginal - prevention & control Clotrimazole - administration & dosage Colony Count, Microbial Double-Blind Method Drug Administration Schedule Female Humans Medical sciences Menstruation Pharmacology. Drug treatments Recurrence Vagina - microbiology |
| title | Intermittent prophylactic treatment of recurrent vaginal candidiasis by postmenstrual application of a 500 mg clotrimazole vaginal tablet |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T02%3A44%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Intermittent%20prophylactic%20treatment%20of%20recurrent%20vaginal%20candidiasis%20by%20postmenstrual%20application%20of%20a%20500%20mg%20clotrimazole%20vaginal%20tablet&rft.jtitle=Genitourinary%20Medicine&rft.au=Roth,%20A%20C&rft.date=1990-10-01&rft.volume=66&rft.issue=5&rft.spage=357&rft.epage=360&rft.pages=357-360&rft.issn=0266-4348&rft.eissn=1472-3263&rft.coden=GEMEE2&rft_id=info:doi/10.1136/sti.66.5.357&rft_dat=%3Cproquest_pubme%3E3973172891%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1771031340&rft_id=info:pmid/2245983&rfr_iscdi=true |