The response of the pancreas of the anaesthetized cat to secretin before, during and after reversible vagal blockade
Cooling the cervical vagi of the anaesthetized splanchnectomized cat to 2 degrees C caused a 54.4 +/- 8.8% inhibition of pancreatic electrolyte secretion stimulated submaximally with pure secretin. On rewarming the vagi there was a prolonged increase in secretion rate over and above the control rate...
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| Veröffentlicht in: | The Journal of physiology 1983-09, Vol.342 (1), p.517-526 |
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| creator | Grundy, D Hutson, D Scratcherd, T |
| description | Cooling the cervical vagi of the anaesthetized splanchnectomized cat to 2 degrees C caused a 54.4 +/- 8.8% inhibition of pancreatic
electrolyte secretion stimulated submaximally with pure secretin. On rewarming the vagi there was a prolonged increase in
secretion rate over and above the control rate which existed before cooling. The increase lasted about 90 min. There were
no changes in acid/base status due to interference of the lung inflation reflex which could account for the inhibition of
secretion and the subsequent rebound. Cold block of the cervical vagi increased the transpancreatic electrical conductance,
indicating that vasodilation had occurred and therefore eliminated a vasomotor cause for the inhibition. Electrolyte secretion
was also inhibited by bilateral vagal section. Atropine only partially prevented the inhibitory response to vagal cooling.
A cholinergic mechanism, therefore, accounted for some but not all of the response to vagal cooling. It is concluded that
even in the fasted, anaesthetized animal vagal impulses facilitate the action of secretin on the pancreas. This facilitation
is only partially cholinergic; the major part of the response is due to some non-cholinergic transmitter substance. Such a
mechanism may be necessary to potentiate the action of the very small amounts of secretin which appear to be released during
a meal. |
| doi_str_mv | 10.1113/jphysiol.1983.sp014866 |
| format | Article |
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electrolyte secretion stimulated submaximally with pure secretin. On rewarming the vagi there was a prolonged increase in
secretion rate over and above the control rate which existed before cooling. The increase lasted about 90 min. There were
no changes in acid/base status due to interference of the lung inflation reflex which could account for the inhibition of
secretion and the subsequent rebound. Cold block of the cervical vagi increased the transpancreatic electrical conductance,
indicating that vasodilation had occurred and therefore eliminated a vasomotor cause for the inhibition. Electrolyte secretion
was also inhibited by bilateral vagal section. Atropine only partially prevented the inhibitory response to vagal cooling.
A cholinergic mechanism, therefore, accounted for some but not all of the response to vagal cooling. It is concluded that
even in the fasted, anaesthetized animal vagal impulses facilitate the action of secretin on the pancreas. This facilitation
is only partially cholinergic; the major part of the response is due to some non-cholinergic transmitter substance. Such a
mechanism may be necessary to potentiate the action of the very small amounts of secretin which appear to be released during
a meal.</description><identifier>ISSN: 0022-3751</identifier><identifier>EISSN: 1469-7793</identifier><identifier>DOI: 10.1113/jphysiol.1983.sp014866</identifier><identifier>PMID: 6631748</identifier><identifier>CODEN: JPHYA7</identifier><language>eng</language><publisher>Oxford: The Physiological Society</publisher><subject>Acid-Base Equilibrium ; Animals ; Atropine - pharmacology ; Autonomic Nerve Block ; Biological and medical sciences ; Cats ; Cold Temperature ; Electric Conductivity ; Exocrine pancreas ; Female ; Fundamental and applied biological sciences. Psychology ; Male ; Pancreas - blood supply ; Pancreas - metabolism ; Pancreatic Juice - metabolism ; Potassium - metabolism ; Proteins - metabolism ; Secretin - pharmacology ; Secretory Rate - drug effects ; Sodium - metabolism ; Vagus Nerve - physiology ; Vasodilation ; Vertebrates: digestive system</subject><ispartof>The Journal of physiology, 1983-09, Vol.342 (1), p.517-526</ispartof><rights>1983 The Physiological Society</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5297-c3f3cf21d5dcf26c1e34c01c36f2e0e66ed2adc2b9d5b5901abde0962ea22d063</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1193974/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1193974/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,1412,27905,27906,45555,45556,53772,53774</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9323047$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6631748$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grundy, D</creatorcontrib><creatorcontrib>Hutson, D</creatorcontrib><creatorcontrib>Scratcherd, T</creatorcontrib><title>The response of the pancreas of the anaesthetized cat to secretin before, during and after reversible vagal blockade</title><title>The Journal of physiology</title><addtitle>J Physiol</addtitle><description>Cooling the cervical vagi of the anaesthetized splanchnectomized cat to 2 degrees C caused a 54.4 +/- 8.8% inhibition of pancreatic
electrolyte secretion stimulated submaximally with pure secretin. On rewarming the vagi there was a prolonged increase in
secretion rate over and above the control rate which existed before cooling. The increase lasted about 90 min. There were
no changes in acid/base status due to interference of the lung inflation reflex which could account for the inhibition of
secretion and the subsequent rebound. Cold block of the cervical vagi increased the transpancreatic electrical conductance,
indicating that vasodilation had occurred and therefore eliminated a vasomotor cause for the inhibition. Electrolyte secretion
was also inhibited by bilateral vagal section. Atropine only partially prevented the inhibitory response to vagal cooling.
A cholinergic mechanism, therefore, accounted for some but not all of the response to vagal cooling. It is concluded that
even in the fasted, anaesthetized animal vagal impulses facilitate the action of secretin on the pancreas. This facilitation
is only partially cholinergic; the major part of the response is due to some non-cholinergic transmitter substance. Such a
mechanism may be necessary to potentiate the action of the very small amounts of secretin which appear to be released during
a meal.</description><subject>Acid-Base Equilibrium</subject><subject>Animals</subject><subject>Atropine - pharmacology</subject><subject>Autonomic Nerve Block</subject><subject>Biological and medical sciences</subject><subject>Cats</subject><subject>Cold Temperature</subject><subject>Electric Conductivity</subject><subject>Exocrine pancreas</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Pancreas - blood supply</subject><subject>Pancreas - metabolism</subject><subject>Pancreatic Juice - metabolism</subject><subject>Potassium - metabolism</subject><subject>Proteins - metabolism</subject><subject>Secretin - pharmacology</subject><subject>Secretory Rate - drug effects</subject><subject>Sodium - metabolism</subject><subject>Vagus Nerve - physiology</subject><subject>Vasodilation</subject><subject>Vertebrates: digestive system</subject><issn>0022-3751</issn><issn>1469-7793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU2P0zAQhiMEWroLPwHkA4ILKR47ceoLEqz41EpwKGfLsSeNlzQOdtpV99fjkLaCG6fxzDzzju03y54DXQIAf3M7tIfofLcEueLLOFAoVkI8yBZQCJlXleQPswWljOW8KuFxdhnjLaXAqZQX2YUQHKpitcjGdYskYBx8H5H4howpH3RvAup4ynWvMabD6O7REqNHMnoSMTGj60mNjQ_4mthdcP0mwZboZsSQZPcYoqs7JHu90R2pO29-aotPskeN7iI-Pcar7MfHD-vrz_nNt09frt_d5KZkssoNb7hpGNjSpiAMIC8MBcNFw5CiEGiZtobV0pZ1KSno2iKVgqFmzFLBr7K3s-6wq7doDfZj0J0agtvqcFBeO_Vvp3et2vi9ApBcVkUSeHkUCP7XLv2B2rposOt0j34X1YpWDBhUCRQzaIKPMWBzXgJUTX6pk19q8kud_EqDz_6-4nnsaFDqvzj2dTS6a0KyxsUzJjnjtJj2v5-xO9fh4T-Xq_XX71OBFwzKP494NYu0btPeuYBqHoveOBwPKnEK1ET-Bm7Xx5w</recordid><startdate>19830901</startdate><enddate>19830901</enddate><creator>Grundy, D</creator><creator>Hutson, D</creator><creator>Scratcherd, T</creator><general>The Physiological Society</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19830901</creationdate><title>The response of the pancreas of the anaesthetized cat to secretin before, during and after reversible vagal blockade</title><author>Grundy, D ; Hutson, D ; Scratcherd, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5297-c3f3cf21d5dcf26c1e34c01c36f2e0e66ed2adc2b9d5b5901abde0962ea22d063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Acid-Base Equilibrium</topic><topic>Animals</topic><topic>Atropine - pharmacology</topic><topic>Autonomic Nerve Block</topic><topic>Biological and medical sciences</topic><topic>Cats</topic><topic>Cold Temperature</topic><topic>Electric Conductivity</topic><topic>Exocrine pancreas</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Pancreas - blood supply</topic><topic>Pancreas - metabolism</topic><topic>Pancreatic Juice - metabolism</topic><topic>Potassium - metabolism</topic><topic>Proteins - metabolism</topic><topic>Secretin - pharmacology</topic><topic>Secretory Rate - drug effects</topic><topic>Sodium - metabolism</topic><topic>Vagus Nerve - physiology</topic><topic>Vasodilation</topic><topic>Vertebrates: digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grundy, D</creatorcontrib><creatorcontrib>Hutson, D</creatorcontrib><creatorcontrib>Scratcherd, T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grundy, D</au><au>Hutson, D</au><au>Scratcherd, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The response of the pancreas of the anaesthetized cat to secretin before, during and after reversible vagal blockade</atitle><jtitle>The Journal of physiology</jtitle><addtitle>J Physiol</addtitle><date>1983-09-01</date><risdate>1983</risdate><volume>342</volume><issue>1</issue><spage>517</spage><epage>526</epage><pages>517-526</pages><issn>0022-3751</issn><eissn>1469-7793</eissn><coden>JPHYA7</coden><abstract>Cooling the cervical vagi of the anaesthetized splanchnectomized cat to 2 degrees C caused a 54.4 +/- 8.8% inhibition of pancreatic
electrolyte secretion stimulated submaximally with pure secretin. On rewarming the vagi there was a prolonged increase in
secretion rate over and above the control rate which existed before cooling. The increase lasted about 90 min. There were
no changes in acid/base status due to interference of the lung inflation reflex which could account for the inhibition of
secretion and the subsequent rebound. Cold block of the cervical vagi increased the transpancreatic electrical conductance,
indicating that vasodilation had occurred and therefore eliminated a vasomotor cause for the inhibition. Electrolyte secretion
was also inhibited by bilateral vagal section. Atropine only partially prevented the inhibitory response to vagal cooling.
A cholinergic mechanism, therefore, accounted for some but not all of the response to vagal cooling. It is concluded that
even in the fasted, anaesthetized animal vagal impulses facilitate the action of secretin on the pancreas. This facilitation
is only partially cholinergic; the major part of the response is due to some non-cholinergic transmitter substance. Such a
mechanism may be necessary to potentiate the action of the very small amounts of secretin which appear to be released during
a meal.</abstract><cop>Oxford</cop><pub>The Physiological Society</pub><pmid>6631748</pmid><doi>10.1113/jphysiol.1983.sp014866</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of physiology, 1983-09, Vol.342 (1), p.517-526 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Acid-Base Equilibrium Animals Atropine - pharmacology Autonomic Nerve Block Biological and medical sciences Cats Cold Temperature Electric Conductivity Exocrine pancreas Female Fundamental and applied biological sciences. Psychology Male Pancreas - blood supply Pancreas - metabolism Pancreatic Juice - metabolism Potassium - metabolism Proteins - metabolism Secretin - pharmacology Secretory Rate - drug effects Sodium - metabolism Vagus Nerve - physiology Vasodilation Vertebrates: digestive system |
| title | The response of the pancreas of the anaesthetized cat to secretin before, during and after reversible vagal blockade |
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