Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34

Mice heterozygous for targeted disruption of Pthrp exhibit, by 3 months of age, diminished bone volume and skeletal microarchitectural changes indicative of advanced osteoporosis. Impaired bone formation arising from decreased BM precursor cell recruitment and increased apoptotic death of osteoblast...

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Veröffentlicht in:	The Journal of clinical investigation 2005-09, Vol.115 (9), p.2402-2411
Hauptverfasser:	Miao, Dengshun, He, Bin, Jiang, Yebin, Kobayashi, Tatsuya, Sorocéanu, Maria A, Zhao, Jenny, Su, Hanyi, Tong, Xinkang, Amizuka, Norio, Gupta, Ajay, Genant, Harry K, Kronenberg, Henry M, Goltzman, David, Karaplis, Andrew C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology Biomedical research Bone and Bones - anatomy & histology Bone and Bones - cytology Bone and Bones - metabolism Bone Density Bone Diseases, Metabolic - genetics Bone Diseases, Metabolic - pathology Gene Targeting Homeostasis Male Mice Mice, Knockout Mice, Transgenic Osteoblasts - cytology Osteoblasts - metabolism Osteogenesis - physiology Osteoporosis Osteoporosis - pathology Osteoporosis - physiopathology Parathyroid Hormone - administration & dosage Parathyroid Hormone - genetics Parathyroid Hormone - metabolism Parathyroid Hormone - therapeutic use Parathyroid Hormone-Related Protein - genetics Parathyroid Hormone-Related Protein - metabolism Peptide Fragments - administration & dosage Peptide Fragments - genetics Peptide Fragments - metabolism Peptide Fragments - therapeutic use Phosphatase Proteins
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