Cardiac action potential duration and contractility in the intact dog heart
The maximum rate of rise of left ventricular pressure (DP) and action potential duration (a.p.d.) were measured in closed-chest anaesthetized dogs with atrioventricular dissociation and beta-adrenergic blockade. Right ventricular stimulation was carried out with protocols consisting of a conditionin...
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| Veröffentlicht in: | The Journal of physiology 1983-12, Vol.345 (1), p.75-85 |
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| creator | Drake-Holland, A.J Noble, M.I.M Pieterse, M Schouten, V.J.A Seed, W.A |
| description | The maximum rate of rise of left ventricular pressure (DP) and action potential duration (a.p.d.) were measured in closed-chest
anaesthetized dogs with atrioventricular dissociation and beta-adrenergic blockade. Right ventricular stimulation was carried
out with protocols consisting of a conditioning 'priming' period and a test period. When a single test stimulus was introduced
at varying intervals after the priming period, DP was found to be maximal at 800-1000 ms. With this single test stimulus fixed
at the optimum, DP was found to be a variable inverse function of the a.p.d. of the same beat; no positive correlation could
be found between DP and a.p.d. When a second test stimulus at the optimum interval was introduced after the first, the DP
(DP2) was found to be strongly dependent on that elicited by the first test stimulus (DP1); the relationship was positive,
linear, independent of the method used to vary DP, and independent of whether DP1 was depressed or potentiated. The slope
of the relationship was less than 1.0 and the line passed through the point where DP2 = DP1; this is the point of continuous
stimulation at the optimum interval in a steady state. This result is consistent with the hypothesis that the coefficient
relating DP1 to DP2, at constant a.p.d. of the first test pulse (AP1), is an index of the proportion of the activator of contraction
stored during relaxation of test beat 1 which is released again on beat 2. In order to test the hypothesis that the remaining
contractility depended on the action potential of test beat 1, AP1 was varied by changing the intervals between the priming
stimuli. In order to determine the relationship between DP2 and AP1 it was necessary to carry out multiple regression analysis
because DP2 was already known to be strongly dependent on DP1 (point 3 above), i.e. DP2 = BDP(DP1) + BAP(AP1 - D). This analysis
yielded highly significant positive values for the coefficients BDP and BAP. This result is compatible with the postulate
that a.p.d. influences the amount of the activator of contraction entering the intracellular store, but that this activator
is not available for release to the contractile proteins until the next depolarization. |
| doi_str_mv | 10.1113/jphysiol.1983.sp014966 |
| format | Article |
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anaesthetized dogs with atrioventricular dissociation and beta-adrenergic blockade. Right ventricular stimulation was carried
out with protocols consisting of a conditioning 'priming' period and a test period. When a single test stimulus was introduced
at varying intervals after the priming period, DP was found to be maximal at 800-1000 ms. With this single test stimulus fixed
at the optimum, DP was found to be a variable inverse function of the a.p.d. of the same beat; no positive correlation could
be found between DP and a.p.d. When a second test stimulus at the optimum interval was introduced after the first, the DP
(DP2) was found to be strongly dependent on that elicited by the first test stimulus (DP1); the relationship was positive,
linear, independent of the method used to vary DP, and independent of whether DP1 was depressed or potentiated. The slope
of the relationship was less than 1.0 and the line passed through the point where DP2 = DP1; this is the point of continuous
stimulation at the optimum interval in a steady state. This result is consistent with the hypothesis that the coefficient
relating DP1 to DP2, at constant a.p.d. of the first test pulse (AP1), is an index of the proportion of the activator of contraction
stored during relaxation of test beat 1 which is released again on beat 2. In order to test the hypothesis that the remaining
contractility depended on the action potential of test beat 1, AP1 was varied by changing the intervals between the priming
stimuli. In order to determine the relationship between DP2 and AP1 it was necessary to carry out multiple regression analysis
because DP2 was already known to be strongly dependent on DP1 (point 3 above), i.e. DP2 = BDP(DP1) + BAP(AP1 - D). This analysis
yielded highly significant positive values for the coefficients BDP and BAP. This result is compatible with the postulate
that a.p.d. influences the amount of the activator of contraction entering the intracellular store, but that this activator
is not available for release to the contractile proteins until the next depolarization.</description><identifier>ISSN: 0022-3751</identifier><identifier>EISSN: 1469-7793</identifier><identifier>DOI: 10.1113/jphysiol.1983.sp014966</identifier><identifier>PMID: 6663514</identifier><identifier>CODEN: JPHYA7</identifier><language>eng</language><publisher>Oxford: The Physiological Society</publisher><subject>Action Potentials ; animal physiology ; Animals ; Biological and medical sciences ; Blood Pressure ; Dogs ; Fundamental and applied biological sciences. Psychology ; Heart ; Heart - physiology ; Myocardial Contraction ; Regression Analysis ; Time Factors ; Ventricular Function ; Vertebrates: cardiovascular system</subject><ispartof>The Journal of physiology, 1983-12, Vol.345 (1), p.75-85</ispartof><rights>1983 The Physiological Society</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5515-46661f3b8608eec0d152f1c1e6932b4ec52823b04a6c8f969914ac5362a5ffa43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1193785/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1193785/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,27923,27924,45573,45574,53790,53792</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9432687$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6663514$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Drake-Holland, A.J</creatorcontrib><creatorcontrib>Noble, M.I.M</creatorcontrib><creatorcontrib>Pieterse, M</creatorcontrib><creatorcontrib>Schouten, V.J.A</creatorcontrib><creatorcontrib>Seed, W.A</creatorcontrib><title>Cardiac action potential duration and contractility in the intact dog heart</title><title>The Journal of physiology</title><addtitle>J Physiol</addtitle><description>The maximum rate of rise of left ventricular pressure (DP) and action potential duration (a.p.d.) were measured in closed-chest
anaesthetized dogs with atrioventricular dissociation and beta-adrenergic blockade. Right ventricular stimulation was carried
out with protocols consisting of a conditioning 'priming' period and a test period. When a single test stimulus was introduced
at varying intervals after the priming period, DP was found to be maximal at 800-1000 ms. With this single test stimulus fixed
at the optimum, DP was found to be a variable inverse function of the a.p.d. of the same beat; no positive correlation could
be found between DP and a.p.d. When a second test stimulus at the optimum interval was introduced after the first, the DP
(DP2) was found to be strongly dependent on that elicited by the first test stimulus (DP1); the relationship was positive,
linear, independent of the method used to vary DP, and independent of whether DP1 was depressed or potentiated. The slope
of the relationship was less than 1.0 and the line passed through the point where DP2 = DP1; this is the point of continuous
stimulation at the optimum interval in a steady state. This result is consistent with the hypothesis that the coefficient
relating DP1 to DP2, at constant a.p.d. of the first test pulse (AP1), is an index of the proportion of the activator of contraction
stored during relaxation of test beat 1 which is released again on beat 2. In order to test the hypothesis that the remaining
contractility depended on the action potential of test beat 1, AP1 was varied by changing the intervals between the priming
stimuli. In order to determine the relationship between DP2 and AP1 it was necessary to carry out multiple regression analysis
because DP2 was already known to be strongly dependent on DP1 (point 3 above), i.e. DP2 = BDP(DP1) + BAP(AP1 - D). This analysis
yielded highly significant positive values for the coefficients BDP and BAP. This result is compatible with the postulate
that a.p.d. influences the amount of the activator of contraction entering the intracellular store, but that this activator
is not available for release to the contractile proteins until the next depolarization.</description><subject>Action Potentials</subject><subject>animal physiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Dogs</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart</subject><subject>Heart - physiology</subject><subject>Myocardial Contraction</subject><subject>Regression Analysis</subject><subject>Time Factors</subject><subject>Ventricular Function</subject><subject>Vertebrates: cardiovascular system</subject><issn>0022-3751</issn><issn>1469-7793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkktv1DAUhS0EKkPhJwBZVOwy-PqVeINUjXhXAol2bXkcZ-IqEwfbQ5V_j9NMR2XHytK93z3n2scIvQG8BgD6_nbspuh8vwZZ03UcMTApxBO0AiZkWVWSPkUrjAkpacXhOXoR4y3GQLGUZ-hMCEE5sBX6vtGhcdoU2iTnh2L0yQ7J6b5oDkHfl_TQFMYPKcxI79JUuKFInc1HyqWi8buiszqkl-hZq_toXx3Pc3Tz6eP15kt59ePz183lVWk4B16ybA4t3dYC19Ya3AAnLRiwQlKyZdZwUhO6xUwLU7dSSAlMG04F0bxtNaPn6MOiOx62e9sYO-_WqzG4vQ6T8tqpfzuD69TO_1EAklY1zwLvjgLB_z7YmNTeRWP7Xg_WH6Kqcc0qTmcnsYAm-BiDbU8mgNUcg3qIQc0xqIcY8uDrxyuexo7vnvsXx76ORvdt0INx8YRJRomoq4xdLtid6-30n-bq-tvPuUAZh-rRZTu36-5csGqZit44myaVMQXqHny7gK32Su9C3ufmF5m_DOFEkqz4F5L9wCo</recordid><startdate>19831201</startdate><enddate>19831201</enddate><creator>Drake-Holland, A.J</creator><creator>Noble, M.I.M</creator><creator>Pieterse, M</creator><creator>Schouten, V.J.A</creator><creator>Seed, W.A</creator><general>The Physiological Society</general><general>Blackwell</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19831201</creationdate><title>Cardiac action potential duration and contractility in the intact dog heart</title><author>Drake-Holland, A.J ; Noble, M.I.M ; Pieterse, M ; Schouten, V.J.A ; Seed, W.A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5515-46661f3b8608eec0d152f1c1e6932b4ec52823b04a6c8f969914ac5362a5ffa43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Action Potentials</topic><topic>animal physiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure</topic><topic>Dogs</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart</topic><topic>Heart - physiology</topic><topic>Myocardial Contraction</topic><topic>Regression Analysis</topic><topic>Time Factors</topic><topic>Ventricular Function</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Drake-Holland, A.J</creatorcontrib><creatorcontrib>Noble, M.I.M</creatorcontrib><creatorcontrib>Pieterse, M</creatorcontrib><creatorcontrib>Schouten, V.J.A</creatorcontrib><creatorcontrib>Seed, W.A</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Drake-Holland, A.J</au><au>Noble, M.I.M</au><au>Pieterse, M</au><au>Schouten, V.J.A</au><au>Seed, W.A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiac action potential duration and contractility in the intact dog heart</atitle><jtitle>The Journal of physiology</jtitle><addtitle>J Physiol</addtitle><date>1983-12-01</date><risdate>1983</risdate><volume>345</volume><issue>1</issue><spage>75</spage><epage>85</epage><pages>75-85</pages><issn>0022-3751</issn><eissn>1469-7793</eissn><coden>JPHYA7</coden><abstract>The maximum rate of rise of left ventricular pressure (DP) and action potential duration (a.p.d.) were measured in closed-chest
anaesthetized dogs with atrioventricular dissociation and beta-adrenergic blockade. Right ventricular stimulation was carried
out with protocols consisting of a conditioning 'priming' period and a test period. When a single test stimulus was introduced
at varying intervals after the priming period, DP was found to be maximal at 800-1000 ms. With this single test stimulus fixed
at the optimum, DP was found to be a variable inverse function of the a.p.d. of the same beat; no positive correlation could
be found between DP and a.p.d. When a second test stimulus at the optimum interval was introduced after the first, the DP
(DP2) was found to be strongly dependent on that elicited by the first test stimulus (DP1); the relationship was positive,
linear, independent of the method used to vary DP, and independent of whether DP1 was depressed or potentiated. The slope
of the relationship was less than 1.0 and the line passed through the point where DP2 = DP1; this is the point of continuous
stimulation at the optimum interval in a steady state. This result is consistent with the hypothesis that the coefficient
relating DP1 to DP2, at constant a.p.d. of the first test pulse (AP1), is an index of the proportion of the activator of contraction
stored during relaxation of test beat 1 which is released again on beat 2. In order to test the hypothesis that the remaining
contractility depended on the action potential of test beat 1, AP1 was varied by changing the intervals between the priming
stimuli. In order to determine the relationship between DP2 and AP1 it was necessary to carry out multiple regression analysis
because DP2 was already known to be strongly dependent on DP1 (point 3 above), i.e. DP2 = BDP(DP1) + BAP(AP1 - D). This analysis
yielded highly significant positive values for the coefficients BDP and BAP. This result is compatible with the postulate
that a.p.d. influences the amount of the activator of contraction entering the intracellular store, but that this activator
is not available for release to the contractile proteins until the next depolarization.</abstract><cop>Oxford</cop><pub>The Physiological Society</pub><pmid>6663514</pmid><doi>10.1113/jphysiol.1983.sp014966</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Online Library All Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Action Potentials animal physiology Animals Biological and medical sciences Blood Pressure Dogs Fundamental and applied biological sciences. Psychology Heart Heart - physiology Myocardial Contraction Regression Analysis Time Factors Ventricular Function Vertebrates: cardiovascular system |
| title | Cardiac action potential duration and contractility in the intact dog heart |
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