The effects of oestrogens on spontaneous activity and responses to phenylephrine of the mammalian urethra
The electrical and mechanical activity of strips of urethral smooth muscle from female ovariectomized rabbits were studied. Results were compared with strips from guinea-pigs, dogs and Tammar wallabies and with anaesthetized rabbits. From pressure recordings in intact animals and contractile respons...
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| Veröffentlicht in: | The Journal of physiology 1985-01, Vol.358 (1), p.35-46 |
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| creator | Callahan, S M Creed, K E |
| description | The electrical and mechanical activity of strips of urethral smooth muscle from female ovariectomized rabbits were studied.
Results were compared with strips from guinea-pigs, dogs and Tammar wallabies and with anaesthetized rabbits. From pressure
recordings in intact animals and contractile responses of strips it was concluded that in the urethra of the rabbit both cholinergic
and alpha-adrenergic receptors were excitatory. Urethral strips from rabbits and wallabies had continuous spontaneous mechanical
activity that was reduced by pre-treatment with oestrogen. In dogs spontaneous activity was transient and in guinea-pigs was
usually absent. The alpha-adrenergic agonist, phenylephrine, produced a dose-related contraction of urethral strips from all
species. Pre-treatment with oestrogen produced no significant change in the rabbit and guinea-pig but increased sensitivity
in the dog and wallaby. Electrical activity was recorded with micro-electrodes from smooth muscle cells of rabbit and guinea-pig
urethra. In both species pre-treatment with oestrogen produced slight depolarization. In rabbits regular spike activity was
recorded from all animals but there was a tendency for double spikes and reduced amplitude following oestrogen treatment.
In guinea-pigs bursts of spikes occurred in control animals; after hormone treatment there was often incomplete recovery of
spikes within the burst. The results indicate that oestrogens can influence the smooth muscle of the urethra by modifying
both spontaneous activity and the responses to stimulation of alpha-adrenoceptors. |
| doi_str_mv | 10.1113/jphysiol.1985.sp015538 |
| format | Article |
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Results were compared with strips from guinea-pigs, dogs and Tammar wallabies and with anaesthetized rabbits. From pressure
recordings in intact animals and contractile responses of strips it was concluded that in the urethra of the rabbit both cholinergic
and alpha-adrenergic receptors were excitatory. Urethral strips from rabbits and wallabies had continuous spontaneous mechanical
activity that was reduced by pre-treatment with oestrogen. In dogs spontaneous activity was transient and in guinea-pigs was
usually absent. The alpha-adrenergic agonist, phenylephrine, produced a dose-related contraction of urethral strips from all
species. Pre-treatment with oestrogen produced no significant change in the rabbit and guinea-pig but increased sensitivity
in the dog and wallaby. Electrical activity was recorded with micro-electrodes from smooth muscle cells of rabbit and guinea-pig
urethra. In both species pre-treatment with oestrogen produced slight depolarization. In rabbits regular spike activity was
recorded from all animals but there was a tendency for double spikes and reduced amplitude following oestrogen treatment.
In guinea-pigs bursts of spikes occurred in control animals; after hormone treatment there was often incomplete recovery of
spikes within the burst. The results indicate that oestrogens can influence the smooth muscle of the urethra by modifying
both spontaneous activity and the responses to stimulation of alpha-adrenoceptors.</description><identifier>ISSN: 0022-3751</identifier><identifier>EISSN: 1469-7793</identifier><identifier>DOI: 10.1113/jphysiol.1985.sp015538</identifier><identifier>PMID: 3981469</identifier><identifier>CODEN: JPHYA7</identifier><language>eng</language><publisher>Oxford: The Physiological Society</publisher><subject>Animals ; Biological and medical sciences ; Calcium - metabolism ; Castration ; Diethylstilbestrol - pharmacology ; Dogs ; Dose-Response Relationship, Drug ; electrical properties ; estrogens ; Female ; Fundamental and applied biological sciences. Psychology ; Guinea Pigs ; Humans ; In Vitro Techniques ; Macropodidae ; Male ; Mammalia ; Muscle Contraction - drug effects ; Muscle, Smooth - drug effects ; phenylephrine ; Phenylephrine - pharmacology ; Rabbits ; urethra ; Urethra - physiology ; Urinary Bladder - physiology ; Vertebrates: urinary system</subject><ispartof>The Journal of physiology, 1985-01, Vol.358 (1), p.35-46</ispartof><rights>1985 The Physiological Society</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4735-f0a73a0e304e819805d46ebc1af32390fc876c9f887c7b22f3aa27bac65b34a23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1193329/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1193329/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,4010,27900,27901,27902,45550,45551,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8426945$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3981469$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Callahan, S M</creatorcontrib><creatorcontrib>Creed, K E</creatorcontrib><title>The effects of oestrogens on spontaneous activity and responses to phenylephrine of the mammalian urethra</title><title>The Journal of physiology</title><addtitle>J Physiol</addtitle><description>The electrical and mechanical activity of strips of urethral smooth muscle from female ovariectomized rabbits were studied.
Results were compared with strips from guinea-pigs, dogs and Tammar wallabies and with anaesthetized rabbits. From pressure
recordings in intact animals and contractile responses of strips it was concluded that in the urethra of the rabbit both cholinergic
and alpha-adrenergic receptors were excitatory. Urethral strips from rabbits and wallabies had continuous spontaneous mechanical
activity that was reduced by pre-treatment with oestrogen. In dogs spontaneous activity was transient and in guinea-pigs was
usually absent. The alpha-adrenergic agonist, phenylephrine, produced a dose-related contraction of urethral strips from all
species. Pre-treatment with oestrogen produced no significant change in the rabbit and guinea-pig but increased sensitivity
in the dog and wallaby. Electrical activity was recorded with micro-electrodes from smooth muscle cells of rabbit and guinea-pig
urethra. In both species pre-treatment with oestrogen produced slight depolarization. In rabbits regular spike activity was
recorded from all animals but there was a tendency for double spikes and reduced amplitude following oestrogen treatment.
In guinea-pigs bursts of spikes occurred in control animals; after hormone treatment there was often incomplete recovery of
spikes within the burst. The results indicate that oestrogens can influence the smooth muscle of the urethra by modifying
both spontaneous activity and the responses to stimulation of alpha-adrenoceptors.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calcium - metabolism</subject><subject>Castration</subject><subject>Diethylstilbestrol - pharmacology</subject><subject>Dogs</subject><subject>Dose-Response Relationship, Drug</subject><subject>electrical properties</subject><subject>estrogens</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Guinea Pigs</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Macropodidae</subject><subject>Male</subject><subject>Mammalia</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle, Smooth - drug effects</subject><subject>phenylephrine</subject><subject>Phenylephrine - pharmacology</subject><subject>Rabbits</subject><subject>urethra</subject><subject>Urethra - physiology</subject><subject>Urinary Bladder - physiology</subject><subject>Vertebrates: urinary system</subject><issn>0022-3751</issn><issn>1469-7793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUcFu1DAQjRCobAufAMoBcctix3EcX5CqCgqoEhyWszXxjjeuEjvY2Vb5exxlu8CNiy37vXkz816WvaVkSyllH-7Hbo7W91sqG76NI6Gcs-ZZtqFVLQshJHuebQgpy4IJTl9mlzHeE0IZkfIiu2CyWXibzO46zNEY1FPMvck9xin4A7r0cnkcvZvAoT_GHPRkH-w05-D2ecAFihjzyedjh27uceyCdbiITElzgGGA3oLLjwGnLsCr7IWBPuLr032V_fz8aXfzpbj7fvv15vqu0JVgvDAEBAOCjFTYpN0I31c1tpqCYSWTxOhG1FqaphFatGVpGEApWtA1b1kFJbvKPq6647EdcK_RTQF6NQY7QJiVB6v-RZzt1ME_KEolY6VMAu9PAsH_OiY_1GCjxr5fjVCLcaQUdSLWK1EHH2NAc25CiVpCUk8hqSUk9RRSKnzz94jnslMqCX93wiFq6E0Ap20805qqrGXFE-16pT3aHuf_bK52334sH4w3lPE_y3b20D3agGqtil5bnNJIvFE0new3ZO7Dmw</recordid><startdate>19850101</startdate><enddate>19850101</enddate><creator>Callahan, S M</creator><creator>Creed, K E</creator><general>The Physiological Society</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>19850101</creationdate><title>The effects of oestrogens on spontaneous activity and responses to phenylephrine of the mammalian urethra</title><author>Callahan, S M ; Creed, K E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4735-f0a73a0e304e819805d46ebc1af32390fc876c9f887c7b22f3aa27bac65b34a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Calcium - metabolism</topic><topic>Castration</topic><topic>Diethylstilbestrol - pharmacology</topic><topic>Dogs</topic><topic>Dose-Response Relationship, Drug</topic><topic>electrical properties</topic><topic>estrogens</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Guinea Pigs</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Macropodidae</topic><topic>Male</topic><topic>Mammalia</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle, Smooth - drug effects</topic><topic>phenylephrine</topic><topic>Phenylephrine - pharmacology</topic><topic>Rabbits</topic><topic>urethra</topic><topic>Urethra - physiology</topic><topic>Urinary Bladder - physiology</topic><topic>Vertebrates: urinary system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Callahan, S M</creatorcontrib><creatorcontrib>Creed, K E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Callahan, S M</au><au>Creed, K E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of oestrogens on spontaneous activity and responses to phenylephrine of the mammalian urethra</atitle><jtitle>The Journal of physiology</jtitle><addtitle>J Physiol</addtitle><date>1985-01-01</date><risdate>1985</risdate><volume>358</volume><issue>1</issue><spage>35</spage><epage>46</epage><pages>35-46</pages><issn>0022-3751</issn><eissn>1469-7793</eissn><coden>JPHYA7</coden><abstract>The electrical and mechanical activity of strips of urethral smooth muscle from female ovariectomized rabbits were studied.
Results were compared with strips from guinea-pigs, dogs and Tammar wallabies and with anaesthetized rabbits. From pressure
recordings in intact animals and contractile responses of strips it was concluded that in the urethra of the rabbit both cholinergic
and alpha-adrenergic receptors were excitatory. Urethral strips from rabbits and wallabies had continuous spontaneous mechanical
activity that was reduced by pre-treatment with oestrogen. In dogs spontaneous activity was transient and in guinea-pigs was
usually absent. The alpha-adrenergic agonist, phenylephrine, produced a dose-related contraction of urethral strips from all
species. Pre-treatment with oestrogen produced no significant change in the rabbit and guinea-pig but increased sensitivity
in the dog and wallaby. Electrical activity was recorded with micro-electrodes from smooth muscle cells of rabbit and guinea-pig
urethra. In both species pre-treatment with oestrogen produced slight depolarization. In rabbits regular spike activity was
recorded from all animals but there was a tendency for double spikes and reduced amplitude following oestrogen treatment.
In guinea-pigs bursts of spikes occurred in control animals; after hormone treatment there was often incomplete recovery of
spikes within the burst. The results indicate that oestrogens can influence the smooth muscle of the urethra by modifying
both spontaneous activity and the responses to stimulation of alpha-adrenoceptors.</abstract><cop>Oxford</cop><pub>The Physiological Society</pub><pmid>3981469</pmid><doi>10.1113/jphysiol.1985.sp015538</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Calcium - metabolism Castration Diethylstilbestrol - pharmacology Dogs Dose-Response Relationship, Drug electrical properties estrogens Female Fundamental and applied biological sciences. Psychology Guinea Pigs Humans In Vitro Techniques Macropodidae Male Mammalia Muscle Contraction - drug effects Muscle, Smooth - drug effects phenylephrine Phenylephrine - pharmacology Rabbits urethra Urethra - physiology Urinary Bladder - physiology Vertebrates: urinary system |
| title | The effects of oestrogens on spontaneous activity and responses to phenylephrine of the mammalian urethra |
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