The release of histamine by parasympathetic stimulation in guinea-pig auricle and rat ileum
Two preparations, a segment of rat ileum and the vagally innerved guinea-pig auricles, have been used in an analysis of the responses to vagal or to electrical field stimulation. The responses to parasympathetic stimulation were depressed by atropine and by tetrodotoxin, and potentiated by eserine....
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| Veröffentlicht in: | The Journal of physiology 1986-02, Vol.371 (1), p.29-43 |
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| container_title | The Journal of physiology |
| container_volume | 371 |
| creator | BANI-SACCHI, T BARATTINI, M BIANCHI, S BLANDINA, P BRUNELLESCHI, S FANTOZZI, R MANNAIONI, P. F MASINI, E |
| description | Two preparations, a segment of rat ileum and the vagally innerved guinea-pig auricles, have been used in an analysis of the
responses to vagal or to electrical field stimulation. The responses to parasympathetic stimulation were depressed by atropine
and by tetrodotoxin, and potentiated by eserine. Supramaximal stimulation (10-20 Hz) resulted in increased release of acetylcholine
and histamine, both in rat ileum and guinea-pig auricles. The release of histamine after parasympathetic stimulation did not
exhibit tachyphylaxis, and it was not reproduced by non-parasympathetic stimuli. In both preparations, atropine produced a
significant, dose-related reduction of histamine measured in the bath fluid after stimulation, while eserine increased histamine
output. A significant diminution of mast cell granules metachromasia was observed in guinea-pig auricles and in rat intestine
after parasympathetic stimulation. The possibility is discussed that acetylcholine released by parasympathetic stimulation
would in turn evoke the secretion of histamine from tissue mast cells. |
| doi_str_mv | 10.1113/jphysiol.1986.sp015960 |
| format | Article |
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responses to vagal or to electrical field stimulation. The responses to parasympathetic stimulation were depressed by atropine
and by tetrodotoxin, and potentiated by eserine. Supramaximal stimulation (10-20 Hz) resulted in increased release of acetylcholine
and histamine, both in rat ileum and guinea-pig auricles. The release of histamine after parasympathetic stimulation did not
exhibit tachyphylaxis, and it was not reproduced by non-parasympathetic stimuli. In both preparations, atropine produced a
significant, dose-related reduction of histamine measured in the bath fluid after stimulation, while eserine increased histamine
output. A significant diminution of mast cell granules metachromasia was observed in guinea-pig auricles and in rat intestine
after parasympathetic stimulation. The possibility is discussed that acetylcholine released by parasympathetic stimulation
would in turn evoke the secretion of histamine from tissue mast cells.</description><identifier>ISSN: 0022-3751</identifier><identifier>EISSN: 1469-7793</identifier><identifier>DOI: 10.1113/jphysiol.1986.sp015960</identifier><identifier>PMID: 2422351</identifier><identifier>CODEN: JPHYA7</identifier><language>eng</language><publisher>Oxford: The Physiological Society</publisher><subject>Acetylcholine - metabolism ; Animals ; Atrial Function ; Atropine - pharmacology ; Biological and medical sciences ; Cytoplasmic Granules - ultrastructure ; Female ; Fundamental and applied biological sciences. Psychology ; Guinea Pigs ; Histamine Release - drug effects ; Ileum - physiology ; In Vitro Techniques ; Male ; Mast Cells - cytology ; Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ ; Physostigmine - pharmacology ; Rats ; Rats, Inbred Strains ; Staining and Labeling ; Vagus Nerve - physiology ; Vertebrates: nervous system and sense organs</subject><ispartof>The Journal of physiology, 1986-02, Vol.371 (1), p.29-43</ispartof><rights>1986 The Physiological Society</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5919-8b0f6049fcff03e440240211ac8a15e5601acd60858c395f9490a4ec963fc3713</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1192709/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1192709/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1416,27923,27924,45573,45574,53790,53792</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7956412$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2422351$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BANI-SACCHI, T</creatorcontrib><creatorcontrib>BARATTINI, M</creatorcontrib><creatorcontrib>BIANCHI, S</creatorcontrib><creatorcontrib>BLANDINA, P</creatorcontrib><creatorcontrib>BRUNELLESCHI, S</creatorcontrib><creatorcontrib>FANTOZZI, R</creatorcontrib><creatorcontrib>MANNAIONI, P. F</creatorcontrib><creatorcontrib>MASINI, E</creatorcontrib><title>The release of histamine by parasympathetic stimulation in guinea-pig auricle and rat ileum</title><title>The Journal of physiology</title><addtitle>J Physiol</addtitle><description>Two preparations, a segment of rat ileum and the vagally innerved guinea-pig auricles, have been used in an analysis of the
responses to vagal or to electrical field stimulation. The responses to parasympathetic stimulation were depressed by atropine
and by tetrodotoxin, and potentiated by eserine. Supramaximal stimulation (10-20 Hz) resulted in increased release of acetylcholine
and histamine, both in rat ileum and guinea-pig auricles. The release of histamine after parasympathetic stimulation did not
exhibit tachyphylaxis, and it was not reproduced by non-parasympathetic stimuli. In both preparations, atropine produced a
significant, dose-related reduction of histamine measured in the bath fluid after stimulation, while eserine increased histamine
output. A significant diminution of mast cell granules metachromasia was observed in guinea-pig auricles and in rat intestine
after parasympathetic stimulation. The possibility is discussed that acetylcholine released by parasympathetic stimulation
would in turn evoke the secretion of histamine from tissue mast cells.</description><subject>Acetylcholine - metabolism</subject><subject>Animals</subject><subject>Atrial Function</subject><subject>Atropine - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cytoplasmic Granules - ultrastructure</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Guinea Pigs</subject><subject>Histamine Release - drug effects</subject><subject>Ileum - physiology</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Mast Cells - cytology</subject><subject>Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ</subject><subject>Physostigmine - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Staining and Labeling</subject><subject>Vagus Nerve - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0022-3751</issn><issn>1469-7793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUuLFDEUhYMo4zj6E5QsRNxUm1tJJZWNMAw-GdBFu3IRbqeTrgz1Mqmaof69abqnGTcqBBJyvntucg8hr4CtAIC_uxmbJYWhXYGu5SqNDCot2SNyDkLqQinNH5Nzxsqy4KqCp-RZSjeMAWdan5GzUpQlr-Cc_Fw3jkbXOkyODp42IU3Yhd7RzUJHjJiWbsSpcVOwNE2hm1ucwtDT0NPdnDksxrCjOMdgW0ex39KIEw2tm7vn5InHNrkXx_2C_Pj4YX31ubj-9unL1eV1YSsNuqg3zEsmtLfeM-6EYGVeAGhrhMpVkuXjVrK6qi3XlddCMxTOasm95Qr4BXl_8B3nTee21vVTxNaMMXQYFzNgMH8qfWjMbrg1ALpUTGeDN0eDOPyaXZpMF5J1bYu9G-ZklKyBayUy-PavIGQ3UILV7J-eIJRinO-bywNo45BSdP70cGBmH7W5j9rsozb3UefClw-_fSo7Zpv110cdk8XWR-xtSCdM6UoKKDN2ecDucmjLfzY366_f9xd5_FA-GGATds1diM4cqtJgg5sWkzEDJoO_AdCJ19E</recordid><startdate>19860201</startdate><enddate>19860201</enddate><creator>BANI-SACCHI, T</creator><creator>BARATTINI, M</creator><creator>BIANCHI, S</creator><creator>BLANDINA, P</creator><creator>BRUNELLESCHI, S</creator><creator>FANTOZZI, R</creator><creator>MANNAIONI, P. F</creator><creator>MASINI, E</creator><general>The Physiological Society</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19860201</creationdate><title>The release of histamine by parasympathetic stimulation in guinea-pig auricle and rat ileum</title><author>BANI-SACCHI, T ; BARATTINI, M ; BIANCHI, S ; BLANDINA, P ; BRUNELLESCHI, S ; FANTOZZI, R ; MANNAIONI, P. 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Electric organ</topic><topic>Physostigmine - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Staining and Labeling</topic><topic>Vagus Nerve - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BANI-SACCHI, T</creatorcontrib><creatorcontrib>BARATTINI, M</creatorcontrib><creatorcontrib>BIANCHI, S</creatorcontrib><creatorcontrib>BLANDINA, P</creatorcontrib><creatorcontrib>BRUNELLESCHI, S</creatorcontrib><creatorcontrib>FANTOZZI, R</creatorcontrib><creatorcontrib>MANNAIONI, P. 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F</au><au>MASINI, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The release of histamine by parasympathetic stimulation in guinea-pig auricle and rat ileum</atitle><jtitle>The Journal of physiology</jtitle><addtitle>J Physiol</addtitle><date>1986-02-01</date><risdate>1986</risdate><volume>371</volume><issue>1</issue><spage>29</spage><epage>43</epage><pages>29-43</pages><issn>0022-3751</issn><eissn>1469-7793</eissn><coden>JPHYA7</coden><abstract>Two preparations, a segment of rat ileum and the vagally innerved guinea-pig auricles, have been used in an analysis of the
responses to vagal or to electrical field stimulation. The responses to parasympathetic stimulation were depressed by atropine
and by tetrodotoxin, and potentiated by eserine. Supramaximal stimulation (10-20 Hz) resulted in increased release of acetylcholine
and histamine, both in rat ileum and guinea-pig auricles. The release of histamine after parasympathetic stimulation did not
exhibit tachyphylaxis, and it was not reproduced by non-parasympathetic stimuli. In both preparations, atropine produced a
significant, dose-related reduction of histamine measured in the bath fluid after stimulation, while eserine increased histamine
output. A significant diminution of mast cell granules metachromasia was observed in guinea-pig auricles and in rat intestine
after parasympathetic stimulation. The possibility is discussed that acetylcholine released by parasympathetic stimulation
would in turn evoke the secretion of histamine from tissue mast cells.</abstract><cop>Oxford</cop><pub>The Physiological Society</pub><pmid>2422351</pmid><doi>10.1113/jphysiol.1986.sp015960</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of physiology, 1986-02, Vol.371 (1), p.29-43 |
| issn | 0022-3751 1469-7793 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1192709 |
| source | MEDLINE; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals; Wiley Online Library All Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Acetylcholine - metabolism Animals Atrial Function Atropine - pharmacology Biological and medical sciences Cytoplasmic Granules - ultrastructure Female Fundamental and applied biological sciences. Psychology Guinea Pigs Histamine Release - drug effects Ileum - physiology In Vitro Techniques Male Mast Cells - cytology Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ Physostigmine - pharmacology Rats Rats, Inbred Strains Staining and Labeling Vagus Nerve - physiology Vertebrates: nervous system and sense organs |
| title | The release of histamine by parasympathetic stimulation in guinea-pig auricle and rat ileum |
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