Potentiation of gamma-aminobutyric-acid-activated chloride conductance by a steroid anaesthetic in cultured rat spinal neurones

1. Intracellular recordings from cultured rat spinal cord neurones demonstrated that Cl(-)-dependent responses to GABA (gamma-aminobutyric acid) (but not glycine) were increased in amplitude and duration by the steroid anaesthetic alphaxalone (3 alpha-hydroxy-5 alpha-pregnane-11,20-dione) at submicr...

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Veröffentlicht in:	The Journal of physiology 1987-05, Vol.386 (1), p.485-501
Hauptverfasser:	Barker, J L, Harrison, N L, Lange, G D, Owen, D G
Format:	Artikel
Sprache:	eng
Schlagworte:	alphaxalone anesthetics Anesthetics - pharmacology Anesthetics. Neuromuscular blocking agents Animals Biological and medical sciences Cells, Cultured chloride Chlorides - physiology Drug Synergism gamma -aminobutyric acid gamma-Aminobutyric Acid - pharmacology Ion Channels - drug effects Medical sciences Neurons - physiology Neuropharmacology Pharmacology. Drug treatments Pregnanediones - pharmacology Rats spinal cord Spinal Cord - physiology Time Factors
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