Lung C-fibre receptor activation and defensive reflexes in anaesthetized cats
1. With pentobarbitone-anaesthetized cats we have elicited cough reflexes from the tracheobronchial tree and the larynx, and the aspiration and sneeze reflexes from the nasopharynx and the nose respectively. The reflexes were induced by mechanical stimulation of the mucosa, before and during activat...
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| Veröffentlicht in: | The Journal of physiology 1988-08, Vol.402 (1), p.411-420 |
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| creator | Tatar, M Webber, S E Widdicombe, J G |
| description | 1. With pentobarbitone-anaesthetized cats we have elicited cough reflexes from the tracheobronchial tree and the larynx, and
the aspiration and sneeze reflexes from the nasopharynx and the nose respectively. The reflexes were induced by mechanical
stimulation of the mucosa, before and during activation of pulmonary C-fibre receptors by intravenous injections of capsaicin
or phenylbiguanide. 2. During the 20-30 s apnoea due to C-fibre stimulation, the cough reflex from both sites and the sneeze
reflex were completely abolished, whereas the aspiration reflex response was approximately halved. Reflex contractions of
genioglossus muscle still occurred at this time, but were far weaker than in the control state. 3. During the rapid shallow
breathing that immediately followed apnoea due to C-fibre receptor stimulation, the defensive reflexes recovered: the aspiration
and sneeze reflexes fully and the cough reflexes to about half of the control response. 4. Acute hypotension due to haemorrhage,
of a size considerably greater than that due to stimulation of the pulmonary C-fibre receptors, caused no significant inhibition
of the cough reflex from the tracheobronchial tree. 5. We conclude that the pulmonary C-fibre reflex powerfully inhibits airway
defensive reflexes, and that its activation is unlikely to contribute positively to coughing induced by aerosols of capsaicin
and similar agents. |
| doi_str_mv | 10.1113/jphysiol.1988.sp017212 |
| format | Article |
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the aspiration and sneeze reflexes from the nasopharynx and the nose respectively. The reflexes were induced by mechanical
stimulation of the mucosa, before and during activation of pulmonary C-fibre receptors by intravenous injections of capsaicin
or phenylbiguanide. 2. During the 20-30 s apnoea due to C-fibre stimulation, the cough reflex from both sites and the sneeze
reflex were completely abolished, whereas the aspiration reflex response was approximately halved. Reflex contractions of
genioglossus muscle still occurred at this time, but were far weaker than in the control state. 3. During the rapid shallow
breathing that immediately followed apnoea due to C-fibre receptor stimulation, the defensive reflexes recovered: the aspiration
and sneeze reflexes fully and the cough reflexes to about half of the control response. 4. Acute hypotension due to haemorrhage,
of a size considerably greater than that due to stimulation of the pulmonary C-fibre receptors, caused no significant inhibition
of the cough reflex from the tracheobronchial tree. 5. We conclude that the pulmonary C-fibre reflex powerfully inhibits airway
defensive reflexes, and that its activation is unlikely to contribute positively to coughing induced by aerosols of capsaicin
and similar agents.</description><identifier>ISSN: 0022-3751</identifier><identifier>EISSN: 1469-7793</identifier><identifier>DOI: 10.1113/jphysiol.1988.sp017212</identifier><identifier>PMID: 3236245</identifier><identifier>CODEN: JPHYA7</identifier><language>eng</language><publisher>Oxford: The Physiological Society</publisher><subject>Action Potentials - drug effects ; Anesthesia, General ; Animals ; Biguanides - pharmacology ; Biological and medical sciences ; Cardiorespiratory control. Arterial mecano- and chemoreceptor ; Cats ; Cough - physiopathology ; Fundamental and applied biological sciences. Psychology ; Lung - innervation ; Mechanoreceptors - physiopathology ; Nerve Fibers - physiology ; Reflex - physiology ; Respiratory System - physiopathology ; Sneezing - drug effects ; Vertebrates: respiratory system</subject><ispartof>The Journal of physiology, 1988-08, Vol.402 (1), p.411-420</ispartof><rights>1988 The Physiological Society</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5291-dc52c381e5057b775820a8ebf86e03828a5552ce59f2c5d372d4c2421ab073e03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1191899/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1191899/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,27924,27925,45574,45575,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7100070$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3236245$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tatar, M</creatorcontrib><creatorcontrib>Webber, S E</creatorcontrib><creatorcontrib>Widdicombe, J G</creatorcontrib><title>Lung C-fibre receptor activation and defensive reflexes in anaesthetized cats</title><title>The Journal of physiology</title><addtitle>J Physiol</addtitle><description>1. With pentobarbitone-anaesthetized cats we have elicited cough reflexes from the tracheobronchial tree and the larynx, and
the aspiration and sneeze reflexes from the nasopharynx and the nose respectively. The reflexes were induced by mechanical
stimulation of the mucosa, before and during activation of pulmonary C-fibre receptors by intravenous injections of capsaicin
or phenylbiguanide. 2. During the 20-30 s apnoea due to C-fibre stimulation, the cough reflex from both sites and the sneeze
reflex were completely abolished, whereas the aspiration reflex response was approximately halved. Reflex contractions of
genioglossus muscle still occurred at this time, but were far weaker than in the control state. 3. During the rapid shallow
breathing that immediately followed apnoea due to C-fibre receptor stimulation, the defensive reflexes recovered: the aspiration
and sneeze reflexes fully and the cough reflexes to about half of the control response. 4. Acute hypotension due to haemorrhage,
of a size considerably greater than that due to stimulation of the pulmonary C-fibre receptors, caused no significant inhibition
of the cough reflex from the tracheobronchial tree. 5. We conclude that the pulmonary C-fibre reflex powerfully inhibits airway
defensive reflexes, and that its activation is unlikely to contribute positively to coughing induced by aerosols of capsaicin
and similar agents.</description><subject>Action Potentials - drug effects</subject><subject>Anesthesia, General</subject><subject>Animals</subject><subject>Biguanides - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cardiorespiratory control. Arterial mecano- and chemoreceptor</subject><subject>Cats</subject><subject>Cough - physiopathology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Lung - innervation</subject><subject>Mechanoreceptors - physiopathology</subject><subject>Nerve Fibers - physiology</subject><subject>Reflex - physiology</subject><subject>Respiratory System - physiopathology</subject><subject>Sneezing - drug effects</subject><subject>Vertebrates: respiratory system</subject><issn>0022-3751</issn><issn>1469-7793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc2O0zAUhS0EGkrhEUBZIFil-NpxbW-QhopfFcFiWFuOc9N4lCbBTjuUp8dROhXsWFny-e45vj6EvAC6AgD-5nZoTtH37Qq0Uqs4UJAM2AOygGKtcyk1f0gWlDKWcyngMXkS4y2lwKnWV-SKM75mhViQr9tDt8s2ee3LgFlAh8PYh8y60R_t6Psus12VVVhjF_1xIuoWf2HM_KRYjGODo_-NVebsGJ-SR7VtIz47n0vy48P7m82nfPvt4-fN9TZ3gmnIq3Q4rgAFFbKUUihGrcKyVmukXDFlhUgECl0zJyouWVU4VjCwJZU8IUvydvYdDuUeK4fdGGxrhuD3NpxMb735V-l8Y3b90QBoUFong1dng9D_PKQtzN5Hh21rO-wP0UglqQYxJa1n0IU-xrT9JQSomYow90WYqQhzX0QafP73Ey9j559P-suzbqOzbR1s53y8YBIopXLKfzdjd77F03-Gm5sv36eLgjIoErYkr2eTxu-aOx_QzGOxdx7Hk0mcATORfwAZ67ey</recordid><startdate>19880801</startdate><enddate>19880801</enddate><creator>Tatar, M</creator><creator>Webber, S E</creator><creator>Widdicombe, J G</creator><general>The Physiological Society</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19880801</creationdate><title>Lung C-fibre receptor activation and defensive reflexes in anaesthetized cats</title><author>Tatar, M ; Webber, S E ; Widdicombe, J G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5291-dc52c381e5057b775820a8ebf86e03828a5552ce59f2c5d372d4c2421ab073e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Action Potentials - drug effects</topic><topic>Anesthesia, General</topic><topic>Animals</topic><topic>Biguanides - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cardiorespiratory control. Arterial mecano- and chemoreceptor</topic><topic>Cats</topic><topic>Cough - physiopathology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Lung - innervation</topic><topic>Mechanoreceptors - physiopathology</topic><topic>Nerve Fibers - physiology</topic><topic>Reflex - physiology</topic><topic>Respiratory System - physiopathology</topic><topic>Sneezing - drug effects</topic><topic>Vertebrates: respiratory system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tatar, M</creatorcontrib><creatorcontrib>Webber, S E</creatorcontrib><creatorcontrib>Widdicombe, J G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tatar, M</au><au>Webber, S E</au><au>Widdicombe, J G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lung C-fibre receptor activation and defensive reflexes in anaesthetized cats</atitle><jtitle>The Journal of physiology</jtitle><addtitle>J Physiol</addtitle><date>1988-08-01</date><risdate>1988</risdate><volume>402</volume><issue>1</issue><spage>411</spage><epage>420</epage><pages>411-420</pages><issn>0022-3751</issn><eissn>1469-7793</eissn><coden>JPHYA7</coden><abstract>1. With pentobarbitone-anaesthetized cats we have elicited cough reflexes from the tracheobronchial tree and the larynx, and
the aspiration and sneeze reflexes from the nasopharynx and the nose respectively. The reflexes were induced by mechanical
stimulation of the mucosa, before and during activation of pulmonary C-fibre receptors by intravenous injections of capsaicin
or phenylbiguanide. 2. During the 20-30 s apnoea due to C-fibre stimulation, the cough reflex from both sites and the sneeze
reflex were completely abolished, whereas the aspiration reflex response was approximately halved. Reflex contractions of
genioglossus muscle still occurred at this time, but were far weaker than in the control state. 3. During the rapid shallow
breathing that immediately followed apnoea due to C-fibre receptor stimulation, the defensive reflexes recovered: the aspiration
and sneeze reflexes fully and the cough reflexes to about half of the control response. 4. Acute hypotension due to haemorrhage,
of a size considerably greater than that due to stimulation of the pulmonary C-fibre receptors, caused no significant inhibition
of the cough reflex from the tracheobronchial tree. 5. We conclude that the pulmonary C-fibre reflex powerfully inhibits airway
defensive reflexes, and that its activation is unlikely to contribute positively to coughing induced by aerosols of capsaicin
and similar agents.</abstract><cop>Oxford</cop><pub>The Physiological Society</pub><pmid>3236245</pmid><doi>10.1113/jphysiol.1988.sp017212</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Action Potentials - drug effects Anesthesia, General Animals Biguanides - pharmacology Biological and medical sciences Cardiorespiratory control. Arterial mecano- and chemoreceptor Cats Cough - physiopathology Fundamental and applied biological sciences. Psychology Lung - innervation Mechanoreceptors - physiopathology Nerve Fibers - physiology Reflex - physiology Respiratory System - physiopathology Sneezing - drug effects Vertebrates: respiratory system |
| title | Lung C-fibre receptor activation and defensive reflexes in anaesthetized cats |
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