Cardiovascular responses to stimulation of cardiac receptors in the cat and their modification by changes in respiration
1. In cats anaesthetized with a mixture of chloralose and urethane, stimulation of cardiac receptors by left atrial injections of veratridine had little or no effect on pulmonary ventilation but caused bradycardia, systemic hypotension and hindlimb vasodilation with a latency of 3.3 s. 2. The hindli...
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| Veröffentlicht in: | The Journal of physiology 1988-12, Vol.407 (1), p.349-362 |
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| description | 1. In cats anaesthetized with a mixture of chloralose and urethane, stimulation of cardiac receptors by left atrial injections
of veratridine had little or no effect on pulmonary ventilation but caused bradycardia, systemic hypotension and hindlimb
vasodilation with a latency of 3.3 s. 2. The hindlimb vasodilatation was due largely, if not entirely, to a reduction in sympathetic
vasoconstrictor activity. 3. Similar cardiovascular responses occurred when the arterial blood pressure was maintained constant
and also in artificially ventilated animals. 4. When the cardiac receptors were excited during a period of apnoea which was
induced reflexly by electrical stimulation of the central cut end of a superior laryngeal nerve, the cardio-inhibitory response
to left atrial injections of veratridine was enhanced but the size of the vasodilator response was unaffected. 5. In contrast,
the cardiovascular effects of stimulation of the carotid body chemoreceptors, bradycardia and hindlimb vasoconstriction were
enhanced by the laryngeal input. 6. The possible central mechanism responsible for the differential modulation of cardiac
receptor and carotid chemoreceptor reflexes by respiration are discussed. |
| doi_str_mv | 10.1113/jphysiol.1988.sp017419 |
| format | Article |
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of veratridine had little or no effect on pulmonary ventilation but caused bradycardia, systemic hypotension and hindlimb
vasodilation with a latency of 3.3 s. 2. The hindlimb vasodilatation was due largely, if not entirely, to a reduction in sympathetic
vasoconstrictor activity. 3. Similar cardiovascular responses occurred when the arterial blood pressure was maintained constant
and also in artificially ventilated animals. 4. When the cardiac receptors were excited during a period of apnoea which was
induced reflexly by electrical stimulation of the central cut end of a superior laryngeal nerve, the cardio-inhibitory response
to left atrial injections of veratridine was enhanced but the size of the vasodilator response was unaffected. 5. In contrast,
the cardiovascular effects of stimulation of the carotid body chemoreceptors, bradycardia and hindlimb vasoconstriction were
enhanced by the laryngeal input. 6. The possible central mechanism responsible for the differential modulation of cardiac
receptor and carotid chemoreceptor reflexes by respiration are discussed.</description><identifier>ISSN: 0022-3751</identifier><identifier>EISSN: 1469-7793</identifier><identifier>DOI: 10.1113/jphysiol.1988.sp017419</identifier><identifier>PMID: 3256620</identifier><identifier>CODEN: JPHYA7</identifier><language>eng</language><publisher>Oxford: The Physiological Society</publisher><subject>Animals ; Biological and medical sciences ; bradycardia ; Cardiorespiratory control. Arterial mecano- and chemoreceptor ; Cats ; Chemoreceptor Cells - drug effects ; Female ; Fundamental and applied biological sciences. Psychology ; Heart - physiology ; Hemodynamics - drug effects ; Laryngeal Nerves - physiology ; Male ; Reflex - drug effects ; Respiration ; Respiration, Artificial ; vasodilation ; Vasodilation - drug effects ; Veratridine - pharmacology ; Veratrine - analogs & derivatives ; Vertebrates: respiratory system</subject><ispartof>The Journal of physiology, 1988-12, Vol.407 (1), p.349-362</ispartof><rights>1988 The Physiological Society</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5939-25f2b224b46a1f8375766d27d727b57ad153ae7b249d8639a3929c6b04a0992a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1191207/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1191207/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,27901,27902,45550,45551,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7237752$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3256620$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Burgh Daly, M</creatorcontrib><creatorcontrib>Kirkman, E</creatorcontrib><creatorcontrib>Wood, L M</creatorcontrib><title>Cardiovascular responses to stimulation of cardiac receptors in the cat and their modification by changes in respiration</title><title>The Journal of physiology</title><addtitle>J Physiol</addtitle><description>1. In cats anaesthetized with a mixture of chloralose and urethane, stimulation of cardiac receptors by left atrial injections
of veratridine had little or no effect on pulmonary ventilation but caused bradycardia, systemic hypotension and hindlimb
vasodilation with a latency of 3.3 s. 2. The hindlimb vasodilatation was due largely, if not entirely, to a reduction in sympathetic
vasoconstrictor activity. 3. Similar cardiovascular responses occurred when the arterial blood pressure was maintained constant
and also in artificially ventilated animals. 4. When the cardiac receptors were excited during a period of apnoea which was
induced reflexly by electrical stimulation of the central cut end of a superior laryngeal nerve, the cardio-inhibitory response
to left atrial injections of veratridine was enhanced but the size of the vasodilator response was unaffected. 5. In contrast,
the cardiovascular effects of stimulation of the carotid body chemoreceptors, bradycardia and hindlimb vasoconstriction were
enhanced by the laryngeal input. 6. The possible central mechanism responsible for the differential modulation of cardiac
receptor and carotid chemoreceptor reflexes by respiration are discussed.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>bradycardia</subject><subject>Cardiorespiratory control. Arterial mecano- and chemoreceptor</subject><subject>Cats</subject><subject>Chemoreceptor Cells - drug effects</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart - physiology</subject><subject>Hemodynamics - drug effects</subject><subject>Laryngeal Nerves - physiology</subject><subject>Male</subject><subject>Reflex - drug effects</subject><subject>Respiration</subject><subject>Respiration, Artificial</subject><subject>vasodilation</subject><subject>Vasodilation - drug effects</subject><subject>Veratridine - pharmacology</subject><subject>Veratrine - analogs & derivatives</subject><subject>Vertebrates: respiratory system</subject><issn>0022-3751</issn><issn>1469-7793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk9v1DAQxS0EKkvhI4B8QMAli8dO7PiCBCv-qhIcytlyHGfjKomDnW3Jt8dptiu4ACdbfr95ntE8hJ4B2QIAe301tnN0vtuCLMttHAmIHOQ9tIGcy0wIye6jDSGUZkwU8BA9ivGKEGBEyjN0xmjBOSUb9HOnQ-38tY7m0OmAg42jH6KNePI4Tq5Pr5PzA_YNNguqTWKMHScfInYDnlqbhAnroV7uLuDe165xZi2rZmxaPeztLby4u3CrPEYPGt1F--R4nqPvH95f7j5lF18_ft69vchMIZnMaNHQitK8yrmGpkyzCM5rKmpBRVUIXUPBtBUVzWVdciY1k1QaXpFcp0mpZufozeo7Hqre1sYOU9CdGoPrdZiV1079qQyuVXt_rQAkUCKSwYujQfA_DjZOqnfR2K7Tg_WHqEQpJIWCJPDVX0HgnDBZklL-0xOKnDIpF0--gib4GINtTo0DUUsO1F0O1JIDdZeDVPj097FPZcfFJ_35UU-b110T9GBcPGGCMiEKmrB3K3bjOjv_5-fq8su35SEnAli-9PJyNWndvr1xwaq1LHrj7DSrxClQC_kLRqHjXw</recordid><startdate>19881201</startdate><enddate>19881201</enddate><creator>de Burgh Daly, M</creator><creator>Kirkman, E</creator><creator>Wood, L M</creator><general>The Physiological Society</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7QR</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19881201</creationdate><title>Cardiovascular responses to stimulation of cardiac receptors in the cat and their modification by changes in respiration</title><author>de Burgh Daly, M ; Kirkman, E ; Wood, L M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5939-25f2b224b46a1f8375766d27d727b57ad153ae7b249d8639a3929c6b04a0992a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>bradycardia</topic><topic>Cardiorespiratory control. Arterial mecano- and chemoreceptor</topic><topic>Cats</topic><topic>Chemoreceptor Cells - drug effects</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart - physiology</topic><topic>Hemodynamics - drug effects</topic><topic>Laryngeal Nerves - physiology</topic><topic>Male</topic><topic>Reflex - drug effects</topic><topic>Respiration</topic><topic>Respiration, Artificial</topic><topic>vasodilation</topic><topic>Vasodilation - drug effects</topic><topic>Veratridine - pharmacology</topic><topic>Veratrine - analogs & derivatives</topic><topic>Vertebrates: respiratory system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Burgh Daly, M</creatorcontrib><creatorcontrib>Kirkman, E</creatorcontrib><creatorcontrib>Wood, L M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Burgh Daly, M</au><au>Kirkman, E</au><au>Wood, L M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiovascular responses to stimulation of cardiac receptors in the cat and their modification by changes in respiration</atitle><jtitle>The Journal of physiology</jtitle><addtitle>J Physiol</addtitle><date>1988-12-01</date><risdate>1988</risdate><volume>407</volume><issue>1</issue><spage>349</spage><epage>362</epage><pages>349-362</pages><issn>0022-3751</issn><eissn>1469-7793</eissn><coden>JPHYA7</coden><abstract>1. In cats anaesthetized with a mixture of chloralose and urethane, stimulation of cardiac receptors by left atrial injections
of veratridine had little or no effect on pulmonary ventilation but caused bradycardia, systemic hypotension and hindlimb
vasodilation with a latency of 3.3 s. 2. The hindlimb vasodilatation was due largely, if not entirely, to a reduction in sympathetic
vasoconstrictor activity. 3. Similar cardiovascular responses occurred when the arterial blood pressure was maintained constant
and also in artificially ventilated animals. 4. When the cardiac receptors were excited during a period of apnoea which was
induced reflexly by electrical stimulation of the central cut end of a superior laryngeal nerve, the cardio-inhibitory response
to left atrial injections of veratridine was enhanced but the size of the vasodilator response was unaffected. 5. In contrast,
the cardiovascular effects of stimulation of the carotid body chemoreceptors, bradycardia and hindlimb vasoconstriction were
enhanced by the laryngeal input. 6. The possible central mechanism responsible for the differential modulation of cardiac
receptor and carotid chemoreceptor reflexes by respiration are discussed.</abstract><cop>Oxford</cop><pub>The Physiological Society</pub><pmid>3256620</pmid><doi>10.1113/jphysiol.1988.sp017419</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biological and medical sciences bradycardia Cardiorespiratory control. Arterial mecano- and chemoreceptor Cats Chemoreceptor Cells - drug effects Female Fundamental and applied biological sciences. Psychology Heart - physiology Hemodynamics - drug effects Laryngeal Nerves - physiology Male Reflex - drug effects Respiration Respiration, Artificial vasodilation Vasodilation - drug effects Veratridine - pharmacology Veratrine - analogs & derivatives Vertebrates: respiratory system |
| title | Cardiovascular responses to stimulation of cardiac receptors in the cat and their modification by changes in respiration |
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