Local oxygen supply and blood flow regulation in contracting muscle in dogs and rabbits
1. Multiwire surface electrodes were used to measure local hydrogen clearance curves and tissues PO2 in the sartorius muscle in dogs under resting conditions and during stimulation of the muscle at 1, 2, 4, 8 and 20 Hz via the femoral nerve. Tissue oxygen supply was assessed by means of PO2 histogra...
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| Veröffentlicht in: | The Journal of physiology 1990-03, Vol.422 (1), p.227-243 |
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| creator | Harrison, D K Birkenhake, S Knauf, S K Kessler, M |
| description | 1. Multiwire surface electrodes were used to measure local hydrogen clearance curves and tissues PO2 in the sartorius muscle
in dogs under resting conditions and during stimulation of the muscle at 1, 2, 4, 8 and 20 Hz via the femoral nerve. Tissue
oxygen supply was assessed by means of PO2 histograms; evaluation of the initial slopes of the hydrogen clearance curves enabled
the measurement of capillary blood flow. 2. In a further model, the analysis of hydrogen clearance curves measured in the
femoral vein using intravascular needle electrodes in rabbits enabled the distribution of blood flow to be evaluated both
under resting conditions and during direct 2 Hz stimulation of the vastus medialis muscle. 3. Increased oxygen consumption,
induced by stimulation, caused increases in capillary flow which were not necessarily accompanied by augmentation of femoral
artery flow. 4. PO2 histograms provided no evidence of cellular anoxia even at the maximum level of oxygen consumption. 5.
A two-compartment distribution of flow was measured under resting conditions, whereas only one compartment could be resolved
during 2 Hz stimulation of the vastus medialis muscle in the rabbit experiments. A clear redistribution of flow was observed
in the absence of any increase in total flow. 6. A model for oxygen-dependent regulation of capillary blood flow involving
high-flow and normal-flow compartments is proposed. |
| doi_str_mv | 10.1113/jphysiol.1990.sp017981 |
| format | Article |
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in dogs under resting conditions and during stimulation of the muscle at 1, 2, 4, 8 and 20 Hz via the femoral nerve. Tissue
oxygen supply was assessed by means of PO2 histograms; evaluation of the initial slopes of the hydrogen clearance curves enabled
the measurement of capillary blood flow. 2. In a further model, the analysis of hydrogen clearance curves measured in the
femoral vein using intravascular needle electrodes in rabbits enabled the distribution of blood flow to be evaluated both
under resting conditions and during direct 2 Hz stimulation of the vastus medialis muscle. 3. Increased oxygen consumption,
induced by stimulation, caused increases in capillary flow which were not necessarily accompanied by augmentation of femoral
artery flow. 4. PO2 histograms provided no evidence of cellular anoxia even at the maximum level of oxygen consumption. 5.
A two-compartment distribution of flow was measured under resting conditions, whereas only one compartment could be resolved
during 2 Hz stimulation of the vastus medialis muscle in the rabbit experiments. A clear redistribution of flow was observed
in the absence of any increase in total flow. 6. A model for oxygen-dependent regulation of capillary blood flow involving
high-flow and normal-flow compartments is proposed.</description><identifier>ISSN: 0022-3751</identifier><identifier>EISSN: 1469-7793</identifier><identifier>DOI: 10.1113/jphysiol.1990.sp017981</identifier><identifier>PMID: 2352180</identifier><identifier>CODEN: JPHYA7</identifier><language>eng</language><publisher>Oxford: The Physiological Society</publisher><subject>Anesthesia, Intravenous ; Animals ; Biological and medical sciences ; blood flow ; Capillaries - physiology ; Dogs ; Fundamental and applied biological sciences. Psychology ; Models, Biological ; Muscle Contraction - physiology ; Muscles - blood supply ; oxygen ; Oxygen - physiology ; Oxygen Consumption - physiology ; Rabbits ; Regional Blood Flow - physiology ; Striated muscle. Tendons ; Vertebrates: osteoarticular system, musculoskeletal system</subject><ispartof>The Journal of physiology, 1990-03, Vol.422 (1), p.227-243</ispartof><rights>1990 The Physiological Society</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5617-5fc7a5a4f94a5884c132cc1c78e0f4cadb89f0c213c933ed9dd9ec921cfaef1d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1190129/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1190129/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,1418,27929,27930,45579,45580,53796,53798</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19504705$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2352180$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harrison, D K</creatorcontrib><creatorcontrib>Birkenhake, S</creatorcontrib><creatorcontrib>Knauf, S K</creatorcontrib><creatorcontrib>Kessler, M</creatorcontrib><title>Local oxygen supply and blood flow regulation in contracting muscle in dogs and rabbits</title><title>The Journal of physiology</title><addtitle>J Physiol</addtitle><description>1. Multiwire surface electrodes were used to measure local hydrogen clearance curves and tissues PO2 in the sartorius muscle
in dogs under resting conditions and during stimulation of the muscle at 1, 2, 4, 8 and 20 Hz via the femoral nerve. Tissue
oxygen supply was assessed by means of PO2 histograms; evaluation of the initial slopes of the hydrogen clearance curves enabled
the measurement of capillary blood flow. 2. In a further model, the analysis of hydrogen clearance curves measured in the
femoral vein using intravascular needle electrodes in rabbits enabled the distribution of blood flow to be evaluated both
under resting conditions and during direct 2 Hz stimulation of the vastus medialis muscle. 3. Increased oxygen consumption,
induced by stimulation, caused increases in capillary flow which were not necessarily accompanied by augmentation of femoral
artery flow. 4. PO2 histograms provided no evidence of cellular anoxia even at the maximum level of oxygen consumption. 5.
A two-compartment distribution of flow was measured under resting conditions, whereas only one compartment could be resolved
during 2 Hz stimulation of the vastus medialis muscle in the rabbit experiments. A clear redistribution of flow was observed
in the absence of any increase in total flow. 6. A model for oxygen-dependent regulation of capillary blood flow involving
high-flow and normal-flow compartments is proposed.</description><subject>Anesthesia, Intravenous</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>blood flow</subject><subject>Capillaries - physiology</subject><subject>Dogs</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Models, Biological</subject><subject>Muscle Contraction - physiology</subject><subject>Muscles - blood supply</subject><subject>oxygen</subject><subject>Oxygen - physiology</subject><subject>Oxygen Consumption - physiology</subject><subject>Rabbits</subject><subject>Regional Blood Flow - physiology</subject><subject>Striated muscle. Tendons</subject><subject>Vertebrates: osteoarticular system, musculoskeletal system</subject><issn>0022-3751</issn><issn>1469-7793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9v1DAQxS0EKtvCRwDlAj1l8djJOr4gQcVfrQSHIo6Wd2JnXXnjYCcs-fYkZFvgBCdLM7_3PDOPkKdA1wDAX9x0-zG54NcgJV2njoKQFdwjKyg2MhdC8vtkRSljORclPCTnKd1QCpxKeUbOGC8ZVHRFvm4Dap-FH2Nj2iwNXefHTLd1tvMh1Jn14ZhF0wxe9y60mWszDG0fNfaubbLDkNCbuVqHJv3SRb3buT49Ig-s9sk8Pr0X5MvbN9dX7_Ptp3cfrl5tcyw3IPLSotClLqwsdFlVBQJniICiMtQWqOtdJS1FBhwl56aWdS0NSgZotbFQ8wvycvHtht3B1Gjm4bzqojvoOKqgnfq707q9asJ3BSApMDkZPD8ZxPBtMKlXB5fQeK9bE4akpqsyEKX4Jwjlpio4qyZws4AYQ0rR2LtpgKo5O3WbnZqzU7fZTcInf-5yJzuFNfWfnfo6TaHZqFt06be7LGkhaDlxrxfu6LwZ__N3df3x81woGAPG5nUvF5O9a_ZHF41aZCmgM_2oJk6BmsmfA4TK9A</recordid><startdate>19900301</startdate><enddate>19900301</enddate><creator>Harrison, D K</creator><creator>Birkenhake, S</creator><creator>Knauf, S K</creator><creator>Kessler, M</creator><general>The Physiological Society</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19900301</creationdate><title>Local oxygen supply and blood flow regulation in contracting muscle in dogs and rabbits</title><author>Harrison, D K ; Birkenhake, S ; Knauf, S K ; Kessler, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5617-5fc7a5a4f94a5884c132cc1c78e0f4cadb89f0c213c933ed9dd9ec921cfaef1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Anesthesia, Intravenous</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>blood flow</topic><topic>Capillaries - physiology</topic><topic>Dogs</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Models, Biological</topic><topic>Muscle Contraction - physiology</topic><topic>Muscles - blood supply</topic><topic>oxygen</topic><topic>Oxygen - physiology</topic><topic>Oxygen Consumption - physiology</topic><topic>Rabbits</topic><topic>Regional Blood Flow - physiology</topic><topic>Striated muscle. Tendons</topic><topic>Vertebrates: osteoarticular system, musculoskeletal system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harrison, D K</creatorcontrib><creatorcontrib>Birkenhake, S</creatorcontrib><creatorcontrib>Knauf, S K</creatorcontrib><creatorcontrib>Kessler, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harrison, D K</au><au>Birkenhake, S</au><au>Knauf, S K</au><au>Kessler, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Local oxygen supply and blood flow regulation in contracting muscle in dogs and rabbits</atitle><jtitle>The Journal of physiology</jtitle><addtitle>J Physiol</addtitle><date>1990-03-01</date><risdate>1990</risdate><volume>422</volume><issue>1</issue><spage>227</spage><epage>243</epage><pages>227-243</pages><issn>0022-3751</issn><eissn>1469-7793</eissn><coden>JPHYA7</coden><abstract>1. Multiwire surface electrodes were used to measure local hydrogen clearance curves and tissues PO2 in the sartorius muscle
in dogs under resting conditions and during stimulation of the muscle at 1, 2, 4, 8 and 20 Hz via the femoral nerve. Tissue
oxygen supply was assessed by means of PO2 histograms; evaluation of the initial slopes of the hydrogen clearance curves enabled
the measurement of capillary blood flow. 2. In a further model, the analysis of hydrogen clearance curves measured in the
femoral vein using intravascular needle electrodes in rabbits enabled the distribution of blood flow to be evaluated both
under resting conditions and during direct 2 Hz stimulation of the vastus medialis muscle. 3. Increased oxygen consumption,
induced by stimulation, caused increases in capillary flow which were not necessarily accompanied by augmentation of femoral
artery flow. 4. PO2 histograms provided no evidence of cellular anoxia even at the maximum level of oxygen consumption. 5.
A two-compartment distribution of flow was measured under resting conditions, whereas only one compartment could be resolved
during 2 Hz stimulation of the vastus medialis muscle in the rabbit experiments. A clear redistribution of flow was observed
in the absence of any increase in total flow. 6. A model for oxygen-dependent regulation of capillary blood flow involving
high-flow and normal-flow compartments is proposed.</abstract><cop>Oxford</cop><pub>The Physiological Society</pub><pmid>2352180</pmid><doi>10.1113/jphysiol.1990.sp017981</doi><tpages>17</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anesthesia, Intravenous Animals Biological and medical sciences blood flow Capillaries - physiology Dogs Fundamental and applied biological sciences. Psychology Models, Biological Muscle Contraction - physiology Muscles - blood supply oxygen Oxygen - physiology Oxygen Consumption - physiology Rabbits Regional Blood Flow - physiology Striated muscle. Tendons Vertebrates: osteoarticular system, musculoskeletal system |
| title | Local oxygen supply and blood flow regulation in contracting muscle in dogs and rabbits |
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