Reversal and inhibition of cholera toxin-induced secretion in isolated rabbit ileum

1. Cholera toxin (1 microgram/ml) abolished net fluid absorption by everted sacs of rabbit ileum, leading to net fluid secretion. This action occurred via the toxin-catalysed ADP ribosylation of the stimulatory GTP-binding protein Gs which is linked to adenylate cyclase. Nicotinamide (10 mM), a reac...

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Veröffentlicht in:	The Journal of physiology 1990-02, Vol.421 (1), p.399-409
Hauptverfasser:	Falk, G, Freeman, M, Marshall, A T, Prenton, E, Shiells, R A, Slack, I
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - pharmacology Animals Bacterial Toxins - pharmacology Benzamides - pharmacology Biological and medical sciences Cell metabolism, cell oxidation Cell physiology Cholera Toxin - antagonists & inhibitors Cholera Toxin - pharmacology Enterotoxins - pharmacology Escherichia coli Escherichia coli Proteins Fundamental and applied biological sciences. Psychology Hypoxanthines - pharmacology ileum Ileum - metabolism In Vitro Techniques Intestinal Absorption - drug effects Methionine - pharmacology Molecular and cellular biology Niacinamide - pharmacology Rabbits Theophylline - pharmacology toxins
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