ATP-sensitive K+ channels in rat pancreatic beta-cells: modulation by ATP and Mg2+ ions

1. The inside-out configuration of the patch-clamp method was used to study the effects of MgATP, free ATP and Mg2+ on single ATP-sensitive K+ channel currents in rat pancreatic beta-cells. 2. Magnesium ions caused a marked reduction of channel activity: 5 mM-free Mg2+ produced a 50% reduction in th...

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Veröffentlicht in:	The Journal of physiology 1989-09, Vol.416 (1), p.349-367
Hauptverfasser:	Ashcroft, F M, Kakei, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - pharmacokinetics Adenosine Triphosphate - pharmacokinetics Animals Biological and medical sciences Dose-Response Relationship, Drug Endocrine pancreas Fundamental and applied biological sciences. Psychology Islets of Langerhans - metabolism Magnesium - pharmacokinetics Membrane Potentials Morphology. Functional localizations Potassium Channels - drug effects Potassium Channels - metabolism Rats Vertebrates: endocrinology
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