Wnt ligand expression in malignant melanoma: pilot study indicating correlation with histopathological features

Aims: Secreted Wnt ligands are key proteins regulating cell–cell interactions and cell growth and differentiation. These proteins, along with other components of the Wnt signalling pathway, are involved in the malignant transformation of various human cancers, including malignant melanoma. This stud...

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Veröffentlicht in:	Molecular pathology 2003-10, Vol.56 (5), p.280-285
Hauptverfasser:	Pham, K, Milovanovic, T, Barr, R J, Truong, T, Holcombe, R F
Format:	Artikel
Sprache:	eng
Schlagworte:	adenomatous polyposis coli APC Biological and medical sciences Biomarkers, Tumor - metabolism Dermatology Disease Progression DMEM Dulbecco’s modified Eagle’s medium FBS fetal bovine serum Frizzled Frizzled receptor Frizzled Receptors Humans in situ hybridisation In Situ Hybridization LEF1 Ligands lymphoid effector factor 1 Medical sciences melanoma Melanoma - metabolism Melanoma - pathology microphthalmia associated transcription factor Mitf naevi Neoplasm Proteins - metabolism Nevus - metabolism Original Pilot Projects Proteins - metabolism Proto-Oncogene Proteins - metabolism signal transduction Skin Neoplasms - metabolism Skin Neoplasms - pathology T cell factor TCF Tumor Cells, Cultured Tumors of the skin and soft tissue. Premalignant lesions Wnt Wnt Proteins Wnt-5a Protein Wnt2 Protein Zebrafish Proteins
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