Evaluation of paediatric osteosarcomas by classic cytogenetic and CGH analyses
Classic cytogenetic and comparative genomic hybridisation (CGH) data on osteosarcomas have been reported extensively in the literature. However, the number of paediatric osteosarcoma cases studied below the age of 14 years remains relatively small. This study reports four new cases of paediatric ost...
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| Veröffentlicht in: | Molecular pathology 2002-12, Vol.55 (6), p.389-393 |
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| creator | Batanian, J R Cavalli, L R Aldosari, N M Ma, E Sotelo-Avila, C Ramos, M B Rone, J D Thorpe, C M Haddad, B R |
| description | Classic cytogenetic and comparative genomic hybridisation (CGH) data on osteosarcomas have been reported extensively in the literature. However, the number of paediatric osteosarcoma cases studied below the age of 14 years remains relatively small. This study reports four new cases of paediatric osteosarcoma in patients aged 3 to 13 years, evaluated by classic cytogenetics and CGH analyses. Clonal chromosomal alterations were detected in all the cases and included structural rearrangements at 1p11–13, 1q11, 4q27–33, 6p23–25, 6q16–25, 7p13–22, 7q11–36, 11p10–15, 11q23, 17p11.2–13, 21p11, and 21q11–22. The CGH analysis revealed recurrent gains at 1p, 4q, 17p, and 21q and losses at 3q and 16p. Five amplification sites were observed at 1q11–23, 6p21, 8q13, 8q21.3–24.2, and 17p. The data are discussed and compared with other cytogenetic reports in the literature. |
| doi_str_mv | 10.1136/mp.55.6.389 |
| format | Article |
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However, the number of paediatric osteosarcoma cases studied below the age of 14 years remains relatively small. This study reports four new cases of paediatric osteosarcoma in patients aged 3 to 13 years, evaluated by classic cytogenetics and CGH analyses. Clonal chromosomal alterations were detected in all the cases and included structural rearrangements at 1p11–13, 1q11, 4q27–33, 6p23–25, 6q16–25, 7p13–22, 7q11–36, 11p10–15, 11q23, 17p11.2–13, 21p11, and 21q11–22. The CGH analysis revealed recurrent gains at 1p, 4q, 17p, and 21q and losses at 3q and 16p. Five amplification sites were observed at 1q11–23, 6p21, 8q13, 8q21.3–24.2, and 17p. The data are discussed and compared with other cytogenetic reports in the literature.</description><identifier>ISSN: 1366-8714</identifier><identifier>EISSN: 1472-4154</identifier><identifier>DOI: 10.1136/mp.55.6.389</identifier><identifier>PMID: 12456778</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Association of Clinical Pathologists</publisher><subject>Adolescent ; Biological and medical sciences ; Bone Neoplasms - genetics ; Cancer in children ; CGH ; Child ; Child, Preschool ; Chromosome Aberrations ; chromosome alterations ; comparative genomic hybridisation ; Cytogenetic Analysis - methods ; Cytogenetics ; Diagnosis ; Diseases of the osteoarticular system ; Female ; G banding using trypsin and Giemsa ; GTG ; Humans ; Karyotyping ; Male ; Medical sciences ; Nucleic Acid Hybridization ; Osteosarcoma ; Osteosarcoma - genetics ; paediatric osteosarcoma ; Pathology, Molecular ; Physiological aspects ; Short Reports ; Tumors of striated muscle and skeleton</subject><ispartof>Molecular pathology, 2002-12, Vol.55 (6), p.389-393</ispartof><rights>Copyright 2002 Journal of Clinical Pathology</rights><rights>2003 INIST-CNRS</rights><rights>COPYRIGHT 2002 BMJ Publishing Group Ltd.</rights><rights>Copyright © 2002, Journal of Clinical Pathology 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b551t-c3ed4caaaf0e65d5f4dd3d7d7d53e9837223b499e4305ff526fd590cc6e9ba0e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1187277/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1187277/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14368948$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12456778$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Batanian, J R</creatorcontrib><creatorcontrib>Cavalli, L R</creatorcontrib><creatorcontrib>Aldosari, N M</creatorcontrib><creatorcontrib>Ma, E</creatorcontrib><creatorcontrib>Sotelo-Avila, C</creatorcontrib><creatorcontrib>Ramos, M B</creatorcontrib><creatorcontrib>Rone, J D</creatorcontrib><creatorcontrib>Thorpe, C M</creatorcontrib><creatorcontrib>Haddad, B R</creatorcontrib><title>Evaluation of paediatric osteosarcomas by classic cytogenetic and CGH analyses</title><title>Molecular pathology</title><addtitle>Mol Path</addtitle><description>Classic cytogenetic and comparative genomic hybridisation (CGH) data on osteosarcomas have been reported extensively in the literature. However, the number of paediatric osteosarcoma cases studied below the age of 14 years remains relatively small. This study reports four new cases of paediatric osteosarcoma in patients aged 3 to 13 years, evaluated by classic cytogenetics and CGH analyses. Clonal chromosomal alterations were detected in all the cases and included structural rearrangements at 1p11–13, 1q11, 4q27–33, 6p23–25, 6q16–25, 7p13–22, 7q11–36, 11p10–15, 11q23, 17p11.2–13, 21p11, and 21q11–22. The CGH analysis revealed recurrent gains at 1p, 4q, 17p, and 21q and losses at 3q and 16p. Five amplification sites were observed at 1q11–23, 6p21, 8q13, 8q21.3–24.2, and 17p. The data are discussed and compared with other cytogenetic reports in the literature.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Bone Neoplasms - genetics</subject><subject>Cancer in children</subject><subject>CGH</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chromosome Aberrations</subject><subject>chromosome alterations</subject><subject>comparative genomic hybridisation</subject><subject>Cytogenetic Analysis - methods</subject><subject>Cytogenetics</subject><subject>Diagnosis</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>G banding using trypsin and Giemsa</subject><subject>GTG</subject><subject>Humans</subject><subject>Karyotyping</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nucleic Acid Hybridization</subject><subject>Osteosarcoma</subject><subject>Osteosarcoma - genetics</subject><subject>paediatric osteosarcoma</subject><subject>Pathology, Molecular</subject><subject>Physiological aspects</subject><subject>Short Reports</subject><subject>Tumors of striated muscle and skeleton</subject><issn>1366-8714</issn><issn>1472-4154</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1v1DAQxSMEoqVw4o5ygQtksePPXCpVq36AqqJKgLhZE2e8uCRxsLNV97_H1a66IFVoDjPy_PQ0z68oXlOyoJTJj8O0EGIhF0w3T4pDylVdcSr40zwzKSutKD8oXqR0QwjRvNbPiwNacyGV0ofF1ekt9GuYfRjL4MoJsPMwR2_LkGYMCaINA6Sy3ZS2h5Tywm7msMIR5zzD2JXL84vcod8kTC-LZw76hK92_aj4dnb6dXlRXX45_7Q8uaxaIehcWYYdtwDgCErRCce7jnUql2DYaKbqmrW8aZAzIpwTtXSdaIi1EpsWCLKj4nirO63bATuL4xyhN1P0A8SNCeDNv5vR_zSrcGso1apWKgu82wnE8HuNaTaDTxb7HkYM62QyxEhNWAY_bMEV9Gj86ELWs_f-s2wY0fn8fNIIqXVDecarR_BcHQ7ePsa_3_I2hpQiugcPlJj7eM0wGSGMNDneTL_52_ae3eWZgbc7AJKF3kUYrU97jjOpG673Z_qc8t3DHuIvIxVTwlx9Xxp-_aO-Zp-J0fvvaoeb_174B_ZlynQ</recordid><startdate>20021201</startdate><enddate>20021201</enddate><creator>Batanian, J R</creator><creator>Cavalli, L R</creator><creator>Aldosari, N M</creator><creator>Ma, E</creator><creator>Sotelo-Avila, C</creator><creator>Ramos, M B</creator><creator>Rone, J D</creator><creator>Thorpe, C M</creator><creator>Haddad, B R</creator><general>BMJ Publishing Group Ltd and Association of Clinical Pathologists</general><general>BMJ</general><general>BMJ Publishing Group Ltd</general><general>British Medical Journal Publishing Group</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20021201</creationdate><title>Evaluation of paediatric osteosarcomas by classic cytogenetic and CGH analyses</title><author>Batanian, J R ; Cavalli, L R ; Aldosari, N M ; Ma, E ; Sotelo-Avila, C ; Ramos, M B ; Rone, J D ; Thorpe, C M ; Haddad, B R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b551t-c3ed4caaaf0e65d5f4dd3d7d7d53e9837223b499e4305ff526fd590cc6e9ba0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Bone Neoplasms - genetics</topic><topic>Cancer in children</topic><topic>CGH</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chromosome Aberrations</topic><topic>chromosome alterations</topic><topic>comparative genomic hybridisation</topic><topic>Cytogenetic Analysis - methods</topic><topic>Cytogenetics</topic><topic>Diagnosis</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>G banding using trypsin and Giemsa</topic><topic>GTG</topic><topic>Humans</topic><topic>Karyotyping</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nucleic Acid Hybridization</topic><topic>Osteosarcoma</topic><topic>Osteosarcoma - genetics</topic><topic>paediatric osteosarcoma</topic><topic>Pathology, Molecular</topic><topic>Physiological aspects</topic><topic>Short Reports</topic><topic>Tumors of striated muscle and skeleton</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Batanian, J R</creatorcontrib><creatorcontrib>Cavalli, L R</creatorcontrib><creatorcontrib>Aldosari, N M</creatorcontrib><creatorcontrib>Ma, E</creatorcontrib><creatorcontrib>Sotelo-Avila, C</creatorcontrib><creatorcontrib>Ramos, M B</creatorcontrib><creatorcontrib>Rone, J D</creatorcontrib><creatorcontrib>Thorpe, C M</creatorcontrib><creatorcontrib>Haddad, B R</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Batanian, J R</au><au>Cavalli, L R</au><au>Aldosari, N M</au><au>Ma, E</au><au>Sotelo-Avila, C</au><au>Ramos, M B</au><au>Rone, J D</au><au>Thorpe, C M</au><au>Haddad, B R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of paediatric osteosarcomas by classic cytogenetic and CGH analyses</atitle><jtitle>Molecular pathology</jtitle><addtitle>Mol Path</addtitle><date>2002-12-01</date><risdate>2002</risdate><volume>55</volume><issue>6</issue><spage>389</spage><epage>393</epage><pages>389-393</pages><issn>1366-8714</issn><eissn>1472-4154</eissn><abstract>Classic cytogenetic and comparative genomic hybridisation (CGH) data on osteosarcomas have been reported extensively in the literature. However, the number of paediatric osteosarcoma cases studied below the age of 14 years remains relatively small. This study reports four new cases of paediatric osteosarcoma in patients aged 3 to 13 years, evaluated by classic cytogenetics and CGH analyses. Clonal chromosomal alterations were detected in all the cases and included structural rearrangements at 1p11–13, 1q11, 4q27–33, 6p23–25, 6q16–25, 7p13–22, 7q11–36, 11p10–15, 11q23, 17p11.2–13, 21p11, and 21q11–22. The CGH analysis revealed recurrent gains at 1p, 4q, 17p, and 21q and losses at 3q and 16p. Five amplification sites were observed at 1q11–23, 6p21, 8q13, 8q21.3–24.2, and 17p. The data are discussed and compared with other cytogenetic reports in the literature.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Association of Clinical Pathologists</pub><pmid>12456778</pmid><doi>10.1136/mp.55.6.389</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Biological and medical sciences Bone Neoplasms - genetics Cancer in children CGH Child Child, Preschool Chromosome Aberrations chromosome alterations comparative genomic hybridisation Cytogenetic Analysis - methods Cytogenetics Diagnosis Diseases of the osteoarticular system Female G banding using trypsin and Giemsa GTG Humans Karyotyping Male Medical sciences Nucleic Acid Hybridization Osteosarcoma Osteosarcoma - genetics paediatric osteosarcoma Pathology, Molecular Physiological aspects Short Reports Tumors of striated muscle and skeleton |
| title | Evaluation of paediatric osteosarcomas by classic cytogenetic and CGH analyses |
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