IGFs and IGFBPs: surrogate markers for diagnosis and surveillance of tumour growth?

Insulin-like growth factors (IGFs), IGF receptors, and IGF binding proteins (IGFBPs) constitute the IGF system. Comprehensive data indicate that these factors play a pivotal role in tumorigenesis. Epidemiological data indicate that cancer risk is associated with high serum IGF-I values. Because dysr...

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Veröffentlicht in:	Molecular pathology 2001-10, Vol.54 (5), p.285-288
1. Verfasser:	Zumkeller, W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biomarkers, Tumor - blood Breast Neoplasms - metabolism Cancer Carrier proteins Colorectal Neoplasms - metabolism Female Host-tumor relations. Immunology. Biological markers Humans insulin-like growth factor binding proteins Insulin-Like Growth Factor Binding Proteins - blood Insulin-Like Growth Factor I - analysis Insulin-Like Growth Factor II - analysis Insulin-like growth factors Male Medical sciences Mice Mice, Transgenic Molecular biology Physiological aspects Prostatic Neoplasms - metabolism Rats Receptor, IGF Type 1 - blood Receptor, IGF Type 2 - blood Review Tumor markers Tumors tumour marker
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Beschreibung
Zusammenfassung:	Insulin-like growth factors (IGFs), IGF receptors, and IGF binding proteins (IGFBPs) constitute the IGF system. Comprehensive data indicate that these factors play a pivotal role in tumorigenesis. Epidemiological data indicate that cancer risk is associated with high serum IGF-I values. Because dysregulation of the IGF system is a frequent pattern in malignancy, IGFs/IGFBPs might represent novel tumour markers that could be useful both for diagnosis and surveillance.
ISSN:	1366-8714 1472-4154
DOI:	10.1136/mp.54.5.285