The IGF system in thyroid cancer: new concepts

In recent years, the activation of the insulin-like growth factor (IGF) system in cancer has emerged as a key factor for tumour progression and resistance to apoptosis. Therefore, a variety of strategies have been developed to block the type I IGF receptor (IGF-I-R), which is thought to mediate the...

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Veröffentlicht in:	Molecular pathology 2001-06, Vol.54 (3), p.121-125
Hauptverfasser:	Vella, V, Sciacca, L, Pandini, G, Mineo, R, Squatrito, S, Vigneri, R, Belfiore, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Carcinoma, Papillary - metabolism Case-Control Studies Endocrinopathies Enzyme-Linked Immunosorbent Assay Genetic aspects Growth Humans insulin receptor Insulin-like growth factor 1 Insulin-Like Growth Factor I - metabolism insulin-like growth factor I receptor Insulin-Like Growth Factor II - metabolism insulin-like growth factor system Malignant tumors Medical sciences Protein Isoforms - metabolism Receptor, IGF Type 1 - metabolism Receptor, IGF Type 2 - metabolism Receptor, Insulin - metabolism Review Stromal Cells - metabolism Thyroid cancer Thyroid Gland - pathology Thyroid hormones Thyroid Neoplasms - metabolism Thyroid. Thyroid axis (diseases) Tumor Cells, Cultured Tumors
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