Arginine methylation regulates IL-2 gene expression: a role for protein arginine methyltransferase 5 (PRMT5)

Arginine methylation is a post-translational modification resulting in the generation of aDMAs (asymmetrical omega-NG, NG-dimethylated arginines) and sDMAs (symmetrical omega-NG, N'G-dimethylated arginines). The role of arginine methylation in cell signalling and gene expression in T lymphocyte...

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Veröffentlicht in:	Biochemical journal 2005-05, Vol.388 (Pt 1), p.379-386
Hauptverfasser:	Richard, Stéphane, Morel, Mélanie, Cléroux, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Arginine - metabolism Gene Expression Regulation, Enzymologic - physiology Humans Interleukin-2 - biosynthesis Jurkat Cells Methylation Promoter Regions, Genetic Protein Processing, Post-Translational Protein-Arginine N-Methyltransferases - antagonists & inhibitors Protein-Arginine N-Methyltransferases - metabolism RNA Interference RNA, Small Interfering T-Lymphocytes - metabolism
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