The reaction of menadione with haemoglobin. Mechanism and effect of superoxide dismutase

1. Menadione was found to react with both the haem groups and the beta-93 thiol groups of haemoglobin. 2. It oxidized the haem groups of oxyhaemoglobin, giving mainly methaemoglobin and a smaller amount of haemichrome. The reaction rate was decrease in the presence of catalase and markedly accelerat...

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Veröffentlicht in:	Biochemical journal 1979-06, Vol.179 (3), p.665-673
Hauptverfasser:	Winterbourn, C C, French, J K, Claridge, R F
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalase Erythrocytes - drug effects Humans Kinetics Methemoglobin Oxidation-Reduction Oxyhemoglobins Quinones Spectrophotometry Sulfhydryl Compounds - antagonists & inhibitors Superoxide Dismutase Vitamin K - pharmacology
Online-Zugang:	Volltext
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