Inactivation of glutamate dehydrogenase and glutamate synthase from Bacillus megaterium by phenylglyoxal, butane-2,3-dione and pyridoxal 5'-phosphate

Reaction of phenylglyoxal with glutamate dehydrogenase (EC 1.4.1.4), but not with glutamate synthase (EC 2.6.1.53), from Bacillus megaterium resulted in complete loss of enzyme activity. NADPH alone or together with 2-oxoglutarate provided substantial protection from inactivation by phenylglyoxal. S...

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Veröffentlicht in:	Biochemical journal 1978-07, Vol.173 (1), p.53-58
Hauptverfasser:	Hemmilä, I A, Mäntsälä, P I
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes - pharmacology Arginine Bacillus megaterium - enzymology Binding Sites Butanones - pharmacology Diacetyl - pharmacology Glutamate Dehydrogenase - antagonists & inhibitors Glutamate Synthase - antagonists & inhibitors Glyoxal - analogs & derivatives Glyoxal - pharmacology Kinetics NADP - metabolism Pyridoxal Phosphate - pharmacology Transaminases - antagonists & inhibitors
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