A permissive role for the vagus nerves in the genesis of antro-antral reflexes in the anaesthetized ferret
1. The role of the vagus nerves in the genesis of antro-antral reflexes was investigated in the urethane-anaesthetized, splanchnectomized ferret. 2. Antral distension stimulated antral contractions with a threshold volume of 3.5 +/- 0.9 ml (corresponding to an intra-antral pressure of 0.27 +/- 0.11...
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| Veröffentlicht in: | The Journal of physiology 1986-12, Vol.381 (1), p.377-384 |
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| description | 1. The role of the vagus nerves in the genesis of antro-antral reflexes was investigated in the urethane-anaesthetized, splanchnectomized
ferret. 2. Antral distension stimulated antral contractions with a threshold volume of 3.5 +/- 0.9 ml (corresponding to an
intra-antral pressure of 0.27 +/- 0.11 kPa) by a vagal-dependent mechanism as indicated by the attenuated response seen during
vagal blockade by cooling. Atropine (1 mg/kg) abolished the antral response to distension. 3. In vagotomized animals, close
arterial infusions of acetylcholine at a dose sufficient to return antral motility to basal levels led to the reappearance
of the reflex. Low-frequency electrical stimulation of the preganglionic vagal neurones had a similar effect. These effects
were also abolished by atropine (1 mg/kg). 4. Hexamethonium (10-25 mg/kg) suppressed the potentiating effect of acetylcholine,
indicating a ganglionic site of action. The attenuated response to antral distension seen in vagotomized animals in the absence
of exogenous acetylcholine or electrical vagal stimulation was not sensitive to hexamethonium but abolished by atropine (1
mg/kg). 5. The results are consistent with the vagus performing a permissive role in the genesis of antro-antral reflexes
mediated through local enteric pathways. |
| doi_str_mv | 10.1113/jphysiol.1986.sp016332 |
| format | Article |
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ferret. 2. Antral distension stimulated antral contractions with a threshold volume of 3.5 +/- 0.9 ml (corresponding to an
intra-antral pressure of 0.27 +/- 0.11 kPa) by a vagal-dependent mechanism as indicated by the attenuated response seen during
vagal blockade by cooling. Atropine (1 mg/kg) abolished the antral response to distension. 3. In vagotomized animals, close
arterial infusions of acetylcholine at a dose sufficient to return antral motility to basal levels led to the reappearance
of the reflex. Low-frequency electrical stimulation of the preganglionic vagal neurones had a similar effect. These effects
were also abolished by atropine (1 mg/kg). 4. Hexamethonium (10-25 mg/kg) suppressed the potentiating effect of acetylcholine,
indicating a ganglionic site of action. The attenuated response to antral distension seen in vagotomized animals in the absence
of exogenous acetylcholine or electrical vagal stimulation was not sensitive to hexamethonium but abolished by atropine (1
mg/kg). 5. The results are consistent with the vagus performing a permissive role in the genesis of antro-antral reflexes
mediated through local enteric pathways.</description><identifier>ISSN: 0022-3751</identifier><identifier>EISSN: 1469-7793</identifier><identifier>DOI: 10.1113/jphysiol.1986.sp016332</identifier><identifier>PMID: 2887649</identifier><identifier>CODEN: JPHYA7</identifier><language>eng</language><publisher>Oxford: The Physiological Society</publisher><subject>Acetylcholine - pharmacology ; Anesthesia, General ; Animals ; Atropine - pharmacology ; Biological and medical sciences ; Carnivora - physiology ; Ferrets - physiology ; Fundamental and applied biological sciences. Psychology ; Gastrointestinal Motility ; Hexamethonium ; Hexamethonium Compounds - pharmacology ; Mustela ; Mustela putorius furo ; Pressure ; Pyloric Antrum - physiology ; Reflex - drug effects ; Reflex - physiology ; Splanchnic Nerves - physiology ; Stomach ; Vagus Nerve - physiology ; Vertebrates: digestive system</subject><ispartof>The Journal of physiology, 1986-12, Vol.381 (1), p.377-384</ispartof><rights>1986 The Physiological Society</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5937-cb4c98faf0729df36dc98d05cb17d2840a5004c52d07d358dfd7d10aa34a7fc53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1182984/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1182984/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,1412,27905,27906,45555,45556,53772,53774</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8237270$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2887649$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grundy, D</creatorcontrib><creatorcontrib>Hutson, D</creatorcontrib><creatorcontrib>Scratcherd, T</creatorcontrib><title>A permissive role for the vagus nerves in the genesis of antro-antral reflexes in the anaesthetized ferret</title><title>The Journal of physiology</title><addtitle>J Physiol</addtitle><description>1. The role of the vagus nerves in the genesis of antro-antral reflexes was investigated in the urethane-anaesthetized, splanchnectomized
ferret. 2. Antral distension stimulated antral contractions with a threshold volume of 3.5 +/- 0.9 ml (corresponding to an
intra-antral pressure of 0.27 +/- 0.11 kPa) by a vagal-dependent mechanism as indicated by the attenuated response seen during
vagal blockade by cooling. Atropine (1 mg/kg) abolished the antral response to distension. 3. In vagotomized animals, close
arterial infusions of acetylcholine at a dose sufficient to return antral motility to basal levels led to the reappearance
of the reflex. Low-frequency electrical stimulation of the preganglionic vagal neurones had a similar effect. These effects
were also abolished by atropine (1 mg/kg). 4. Hexamethonium (10-25 mg/kg) suppressed the potentiating effect of acetylcholine,
indicating a ganglionic site of action. The attenuated response to antral distension seen in vagotomized animals in the absence
of exogenous acetylcholine or electrical vagal stimulation was not sensitive to hexamethonium but abolished by atropine (1
mg/kg). 5. The results are consistent with the vagus performing a permissive role in the genesis of antro-antral reflexes
mediated through local enteric pathways.</description><subject>Acetylcholine - pharmacology</subject><subject>Anesthesia, General</subject><subject>Animals</subject><subject>Atropine - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Carnivora - physiology</subject><subject>Ferrets - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastrointestinal Motility</subject><subject>Hexamethonium</subject><subject>Hexamethonium Compounds - pharmacology</subject><subject>Mustela</subject><subject>Mustela putorius furo</subject><subject>Pressure</subject><subject>Pyloric Antrum - physiology</subject><subject>Reflex - drug effects</subject><subject>Reflex - physiology</subject><subject>Splanchnic Nerves - physiology</subject><subject>Stomach</subject><subject>Vagus Nerve - physiology</subject><subject>Vertebrates: digestive system</subject><issn>0022-3751</issn><issn>1469-7793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1vEzEQhi0EKmnhJ4B8QMBlg73eXduXSqXiU5XgUM6WY4-zjjbrYG9S0l-Pt5sGuAAXf80zr2fmReg5JXNKKXuz2rT75EM3p1I087QhtGGsfIBmtGpkwblkD9GMkLIsGK_pY3Sa0ooQyoiUJ-ikFII3lZyh1QXeQFz7lPwOcAwdYBciHlrAO73cJtxD3EHCvr97W0IPySccHNb9EEMxrrrDEVwHP35xuteQ8mHwt2CxgxhheIIeOd0leHrYz9C39--uLz8WV18-fLq8uCpMLRkvzKIyUjjtCC-ldayx-WpJbRaU21JURNeEVKYuLeGW1cI6yy0lWrNKc2dqdobOJ93NdrEGa-CuRLWJfq3jXgXt1Z-R3rdqGXaKUlFKUWWBlweBGL5vcx8qz8dA1-kewjYpzhlrmKAZfP1XkHIiKW8aUf5Tk1ZciIbwDDYTaGJIKc_1WDglanRe3TuvRufVvfM58dnvbR_TDlbn-ItDXCejOxd1b3w6YrlGXnKSsbcTduM72P_n5-r689fxIQ-FMj428WoSaf2yvfER1JSWgvEw7FXmFFUj-RMX3t70</recordid><startdate>19861201</startdate><enddate>19861201</enddate><creator>Grundy, D</creator><creator>Hutson, D</creator><creator>Scratcherd, T</creator><general>The Physiological Society</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19861201</creationdate><title>A permissive role for the vagus nerves in the genesis of antro-antral reflexes in the anaesthetized ferret</title><author>Grundy, D ; Hutson, D ; Scratcherd, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5937-cb4c98faf0729df36dc98d05cb17d2840a5004c52d07d358dfd7d10aa34a7fc53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Acetylcholine - pharmacology</topic><topic>Anesthesia, General</topic><topic>Animals</topic><topic>Atropine - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Carnivora - physiology</topic><topic>Ferrets - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastrointestinal Motility</topic><topic>Hexamethonium</topic><topic>Hexamethonium Compounds - pharmacology</topic><topic>Mustela</topic><topic>Mustela putorius furo</topic><topic>Pressure</topic><topic>Pyloric Antrum - physiology</topic><topic>Reflex - drug effects</topic><topic>Reflex - physiology</topic><topic>Splanchnic Nerves - physiology</topic><topic>Stomach</topic><topic>Vagus Nerve - physiology</topic><topic>Vertebrates: digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grundy, D</creatorcontrib><creatorcontrib>Hutson, D</creatorcontrib><creatorcontrib>Scratcherd, T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grundy, D</au><au>Hutson, D</au><au>Scratcherd, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A permissive role for the vagus nerves in the genesis of antro-antral reflexes in the anaesthetized ferret</atitle><jtitle>The Journal of physiology</jtitle><addtitle>J Physiol</addtitle><date>1986-12-01</date><risdate>1986</risdate><volume>381</volume><issue>1</issue><spage>377</spage><epage>384</epage><pages>377-384</pages><issn>0022-3751</issn><eissn>1469-7793</eissn><coden>JPHYA7</coden><abstract>1. The role of the vagus nerves in the genesis of antro-antral reflexes was investigated in the urethane-anaesthetized, splanchnectomized
ferret. 2. Antral distension stimulated antral contractions with a threshold volume of 3.5 +/- 0.9 ml (corresponding to an
intra-antral pressure of 0.27 +/- 0.11 kPa) by a vagal-dependent mechanism as indicated by the attenuated response seen during
vagal blockade by cooling. Atropine (1 mg/kg) abolished the antral response to distension. 3. In vagotomized animals, close
arterial infusions of acetylcholine at a dose sufficient to return antral motility to basal levels led to the reappearance
of the reflex. Low-frequency electrical stimulation of the preganglionic vagal neurones had a similar effect. These effects
were also abolished by atropine (1 mg/kg). 4. Hexamethonium (10-25 mg/kg) suppressed the potentiating effect of acetylcholine,
indicating a ganglionic site of action. The attenuated response to antral distension seen in vagotomized animals in the absence
of exogenous acetylcholine or electrical vagal stimulation was not sensitive to hexamethonium but abolished by atropine (1
mg/kg). 5. The results are consistent with the vagus performing a permissive role in the genesis of antro-antral reflexes
mediated through local enteric pathways.</abstract><cop>Oxford</cop><pub>The Physiological Society</pub><pmid>2887649</pmid><doi>10.1113/jphysiol.1986.sp016332</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acetylcholine - pharmacology Anesthesia, General Animals Atropine - pharmacology Biological and medical sciences Carnivora - physiology Ferrets - physiology Fundamental and applied biological sciences. Psychology Gastrointestinal Motility Hexamethonium Hexamethonium Compounds - pharmacology Mustela Mustela putorius furo Pressure Pyloric Antrum - physiology Reflex - drug effects Reflex - physiology Splanchnic Nerves - physiology Stomach Vagus Nerve - physiology Vertebrates: digestive system |
| title | A permissive role for the vagus nerves in the genesis of antro-antral reflexes in the anaesthetized ferret |
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