Activation and deactivation rates of recombinant GABA(A) receptor channels are dependent on alpha-subunit isoform

The role of subunit composition in determining intrinsic maximum activation and deactivation kinetics of GABA(A) receptor channels is unknown. We used rapid ligand application (100-micros solution exchange) to examine the effects of alpha-subunit composition on GABA-evoked activation and deactivatio...

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Veröffentlicht in:	Biophysical journal 1997-11, Vol.73 (5), p.2518-2526
Hauptverfasser:	Lavoie, A.M., Tingey, J.J., Harrison, N.L., Pritchett, D.B., Twyman, R.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells, Cultured Electrophysiology gamma-Aminobutyric Acid - pharmacology Humans Ion Channels - chemistry Ion Channels - metabolism Kinetics Models, Biological Patch-Clamp Techniques Receptors, GABA-A - chemistry Receptors, GABA-A - genetics Receptors, GABA-A - metabolism Recombinant Proteins - chemistry Recombinant Proteins - metabolism Structure-Activity Relationship Transfection - genetics
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