CARD15: a Pleiotropic Autoimmune Gene That Confers Susceptibility to Psoriatic Arthritis

A recent genomewide scan in psoriatic arthritis (PsA) revealed a susceptibility locus at 16q. This region overlaps CARD15, a susceptibility gene in Crohn disease. The possibility of a common susceptibility gene between PsA and Crohn disease is further supported by epidemiological studies that note a...

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Veröffentlicht in:	American journal of human genetics 2003-09, Vol.73 (3), p.677-681
Hauptverfasser:	Rahman, P., Bartlett, S., Siannis, F., Pellett, F.J., Farewell, V.T., Peddle, L., Schentag, C.T., Alderdice, C.A., Hamilton, S., Khraishi, M., Tobin, Y., Hefferton, D., Gladman, D.D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Arthritis, Psoriatic - genetics Autoimmunity - genetics Carrier Proteins - genetics Female Gene Frequency Genetic Predisposition to Disease Genetic Variation HLA-C Antigens - genetics Humans Intracellular Signaling Peptides and Proteins Male Molecular Sequence Data Mutation Nod2 Signaling Adaptor Protein
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