Risk of hypertension and reduced kidney function after acute gastroenteritis from bacteria-contaminated drinking water
The long-term health consequences of acute bacterial gastroenteritis remain uncertain. We studied the risk of hypertension and reduced kidney function after an outbreak of acute gastroenteritis due to contamination of a regional drinking water supply with Escherichia coli O157:H7 and Campylobacter s...
Gespeichert in:
| Veröffentlicht in: | Canadian Medical Association journal 2005-08, Vol.173 (3), p.261-268 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 268 |
|---|---|
| container_issue | 3 |
| container_start_page | 261 |
| container_title | Canadian Medical Association journal |
| container_volume | 173 |
| creator | Garg, Amit X Moist, Louise Matsell, Douglas Thiessen-Philbrook, Heather R Haynes, R. Brian Suri, Rita S Salvadori, Marina Ray, Joel Clark, William F for The Walkerton Health Study Investigators |
| description | The long-term health consequences of acute bacterial gastroenteritis remain uncertain. We studied the risk of hypertension and reduced kidney function after an outbreak of acute gastroenteritis due to contamination of a regional drinking water supply with Escherichia coli O157:H7 and Campylobacter species.
A total of 1958 adults with no known history of hypertension or kidney disease before the outbreak participated in a long-term follow-up study. Of the participants, 675 had been asymptomatic during the outbreak, 909 had had moderate symptoms of acute self-limited gastroenteritis, and 374 had had severe symptoms that necessitated medical attention. The outcomes of interest were a diagnosis of hypertension or the presence of reduced kidney function and albuminuria during the follow-up period.
After a mean follow-up of 3.7 years after the outbreak, hypertension was diagnosed in 27.0% of participants who had been asymptomatic during the outbreak and in 32.3% and 35.9% of those who had had moderate and severe symptoms of acute gastroenteritis respectively (trend p = 0.009). Compared with the asymptomatic participants, those with moderate and severe symptoms of gastroenteritis had an adjusted relative risk of hypertension of 1.15 (95% confidence interval [CI] 0.97-1.35) and 1.28 (95% CI 1.04-1.56) respectively. A similar graded association was seen for reduced kidney function, defined as the presence of an estimated glomerular filtration rate below 60 mL/min per 1.73 m2 (trend p = 0.03). No association was observed between gastroenteritis and the subsequent risk of albuminuria.
Acute bacterial gastroenteritis necessitating medical attention was associated with an increased risk of hypertension and reduced kidney function 4 years after infection. Maintaining safe drinking water remains essential to human health, as transient bacterial contaminations may have implications well beyond a period of acute self-limited illness. |
| doi_str_mv | 10.1503/cmaj.050581 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1180655</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A134673875</galeid><sourcerecordid>A134673875</sourcerecordid><originalsourceid>FETCH-LOGICAL-c671t-4f192842ecd2d9e381926373db74d55c07df58cbbddfbad31bfc65af2ed40f8d3</originalsourceid><addsrcrecordid>eNqVkt-LEzEQxxdRvHr65LssPhyIbE02-yP7IhyHPw4OhVOfQzaZ7KbdTXpJ9mr_e1NbbCsHInkIM_PJN8PMN0leYjTHJSLvxMgXc1SikuJHyQwXlGY5yZvHyQwhRLOiQM1Z8sz7BUIxj4qnyRkum5wUDZol97faL1Or0n6zAhfAeG1Nyo1MHchJgEyXWhrYpGoyIvyuqQAu5WIKkHbcB2fBxIwO2qfK2TFtudjGPBPWBD5qw0OUkU6bpTZduo6he548UXzw8GJ_nyc_Pn74fvU5u_n66frq8iYTVY1DVijc5LTIQchcNkBoDCtSE9nWhSxLgWqpSiraVkrVcklwq0RVcpWDLJCikpwn73e6q6kdQYrYquMDWzk9crdhlmt2WjG6Z529ZxhTVJVlFLjYCzh7N4EPbNRewDBwA3byrKIFqZqq-SeYI1xhUqAIvv4LXNjJmTiFyBQU5xXeqmU7qOMDMG2Ujd2JDgzEJq0BpWP6MupVNaF1eRA94cVK37FjaP4AFI-EUYsHVd-cPNguFH6Gjk_es-tvt__BfjllL47YHvgQem-Haesvfwq-3YHCWe8dqD-bw4htzc-25mc780f61fGyD-ze7Yd_e931a-2A-ZEPQ8QxW6_XuCaMsDh_8guAhAzf</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>204812619</pqid></control><display><type>article</type><title>Risk of hypertension and reduced kidney function after acute gastroenteritis from bacteria-contaminated drinking water</title><source>MEDLINE</source><source>PubMed Central(OpenAccess)</source><source>Directory of Open Access Journals</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>Garg, Amit X ; Moist, Louise ; Matsell, Douglas ; Thiessen-Philbrook, Heather R ; Haynes, R. Brian ; Suri, Rita S ; Salvadori, Marina ; Ray, Joel ; Clark, William F ; for The Walkerton Health Study Investigators</creator><creatorcontrib>Garg, Amit X ; Moist, Louise ; Matsell, Douglas ; Thiessen-Philbrook, Heather R ; Haynes, R. Brian ; Suri, Rita S ; Salvadori, Marina ; Ray, Joel ; Clark, William F ; for The Walkerton Health Study Investigators ; Walkerton Health Study Investigators</creatorcontrib><description>The long-term health consequences of acute bacterial gastroenteritis remain uncertain. We studied the risk of hypertension and reduced kidney function after an outbreak of acute gastroenteritis due to contamination of a regional drinking water supply with Escherichia coli O157:H7 and Campylobacter species.
A total of 1958 adults with no known history of hypertension or kidney disease before the outbreak participated in a long-term follow-up study. Of the participants, 675 had been asymptomatic during the outbreak, 909 had had moderate symptoms of acute self-limited gastroenteritis, and 374 had had severe symptoms that necessitated medical attention. The outcomes of interest were a diagnosis of hypertension or the presence of reduced kidney function and albuminuria during the follow-up period.
After a mean follow-up of 3.7 years after the outbreak, hypertension was diagnosed in 27.0% of participants who had been asymptomatic during the outbreak and in 32.3% and 35.9% of those who had had moderate and severe symptoms of acute gastroenteritis respectively (trend p = 0.009). Compared with the asymptomatic participants, those with moderate and severe symptoms of gastroenteritis had an adjusted relative risk of hypertension of 1.15 (95% confidence interval [CI] 0.97-1.35) and 1.28 (95% CI 1.04-1.56) respectively. A similar graded association was seen for reduced kidney function, defined as the presence of an estimated glomerular filtration rate below 60 mL/min per 1.73 m2 (trend p = 0.03). No association was observed between gastroenteritis and the subsequent risk of albuminuria.
Acute bacterial gastroenteritis necessitating medical attention was associated with an increased risk of hypertension and reduced kidney function 4 years after infection. Maintaining safe drinking water remains essential to human health, as transient bacterial contaminations may have implications well beyond a period of acute self-limited illness.</description><identifier>ISSN: 0008-4409</identifier><identifier>ISSN: 0820-3946</identifier><identifier>EISSN: 1488-2329</identifier><identifier>DOI: 10.1503/cmaj.050581</identifier><identifier>PMID: 15923490</identifier><identifier>CODEN: CMAJAX</identifier><language>eng</language><publisher>Canada: Can Med Assoc</publisher><subject>Acute Disease ; Adult ; Campylobacter ; Campylobacter Infections - complications ; Causes ; Disease Outbreaks ; Drinking water ; E coli ; Escherichia coli ; Escherichia coli Infections - complications ; Female ; Follow-Up Studies ; Gastroenteritis ; Gastroenteritis - complications ; Gastroenteritis - epidemiology ; Gastroenteritis - microbiology ; Gastrointestinal diseases ; Humans ; Hypertension ; Hypertension - etiology ; Infections ; Kidney diseases ; Kidney Diseases - etiology ; Male ; Middle Aged ; Ontario - epidemiology ; Risk Factors ; Rural Population ; Water Microbiology ; Water Supply</subject><ispartof>Canadian Medical Association journal, 2005-08, Vol.173 (3), p.261-268</ispartof><rights>COPYRIGHT 2005 CMA Impact Inc.</rights><rights>Copyright Canadian Medical Association Aug 2, 2005</rights><rights>2005 CMA Media Inc. or its licensors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c671t-4f192842ecd2d9e381926373db74d55c07df58cbbddfbad31bfc65af2ed40f8d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180655/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180655/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,861,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15923490$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garg, Amit X</creatorcontrib><creatorcontrib>Moist, Louise</creatorcontrib><creatorcontrib>Matsell, Douglas</creatorcontrib><creatorcontrib>Thiessen-Philbrook, Heather R</creatorcontrib><creatorcontrib>Haynes, R. Brian</creatorcontrib><creatorcontrib>Suri, Rita S</creatorcontrib><creatorcontrib>Salvadori, Marina</creatorcontrib><creatorcontrib>Ray, Joel</creatorcontrib><creatorcontrib>Clark, William F</creatorcontrib><creatorcontrib>for The Walkerton Health Study Investigators</creatorcontrib><creatorcontrib>Walkerton Health Study Investigators</creatorcontrib><title>Risk of hypertension and reduced kidney function after acute gastroenteritis from bacteria-contaminated drinking water</title><title>Canadian Medical Association journal</title><addtitle>CMAJ</addtitle><description>The long-term health consequences of acute bacterial gastroenteritis remain uncertain. We studied the risk of hypertension and reduced kidney function after an outbreak of acute gastroenteritis due to contamination of a regional drinking water supply with Escherichia coli O157:H7 and Campylobacter species.
A total of 1958 adults with no known history of hypertension or kidney disease before the outbreak participated in a long-term follow-up study. Of the participants, 675 had been asymptomatic during the outbreak, 909 had had moderate symptoms of acute self-limited gastroenteritis, and 374 had had severe symptoms that necessitated medical attention. The outcomes of interest were a diagnosis of hypertension or the presence of reduced kidney function and albuminuria during the follow-up period.
After a mean follow-up of 3.7 years after the outbreak, hypertension was diagnosed in 27.0% of participants who had been asymptomatic during the outbreak and in 32.3% and 35.9% of those who had had moderate and severe symptoms of acute gastroenteritis respectively (trend p = 0.009). Compared with the asymptomatic participants, those with moderate and severe symptoms of gastroenteritis had an adjusted relative risk of hypertension of 1.15 (95% confidence interval [CI] 0.97-1.35) and 1.28 (95% CI 1.04-1.56) respectively. A similar graded association was seen for reduced kidney function, defined as the presence of an estimated glomerular filtration rate below 60 mL/min per 1.73 m2 (trend p = 0.03). No association was observed between gastroenteritis and the subsequent risk of albuminuria.
Acute bacterial gastroenteritis necessitating medical attention was associated with an increased risk of hypertension and reduced kidney function 4 years after infection. Maintaining safe drinking water remains essential to human health, as transient bacterial contaminations may have implications well beyond a period of acute self-limited illness.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Campylobacter</subject><subject>Campylobacter Infections - complications</subject><subject>Causes</subject><subject>Disease Outbreaks</subject><subject>Drinking water</subject><subject>E coli</subject><subject>Escherichia coli</subject><subject>Escherichia coli Infections - complications</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastroenteritis</subject><subject>Gastroenteritis - complications</subject><subject>Gastroenteritis - epidemiology</subject><subject>Gastroenteritis - microbiology</subject><subject>Gastrointestinal diseases</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - etiology</subject><subject>Infections</subject><subject>Kidney diseases</subject><subject>Kidney Diseases - etiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Ontario - epidemiology</subject><subject>Risk Factors</subject><subject>Rural Population</subject><subject>Water Microbiology</subject><subject>Water Supply</subject><issn>0008-4409</issn><issn>0820-3946</issn><issn>1488-2329</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqVkt-LEzEQxxdRvHr65LssPhyIbE02-yP7IhyHPw4OhVOfQzaZ7KbdTXpJ9mr_e1NbbCsHInkIM_PJN8PMN0leYjTHJSLvxMgXc1SikuJHyQwXlGY5yZvHyQwhRLOiQM1Z8sz7BUIxj4qnyRkum5wUDZol97faL1Or0n6zAhfAeG1Nyo1MHchJgEyXWhrYpGoyIvyuqQAu5WIKkHbcB2fBxIwO2qfK2TFtudjGPBPWBD5qw0OUkU6bpTZduo6he548UXzw8GJ_nyc_Pn74fvU5u_n66frq8iYTVY1DVijc5LTIQchcNkBoDCtSE9nWhSxLgWqpSiraVkrVcklwq0RVcpWDLJCikpwn73e6q6kdQYrYquMDWzk9crdhlmt2WjG6Z529ZxhTVJVlFLjYCzh7N4EPbNRewDBwA3byrKIFqZqq-SeYI1xhUqAIvv4LXNjJmTiFyBQU5xXeqmU7qOMDMG2Ujd2JDgzEJq0BpWP6MupVNaF1eRA94cVK37FjaP4AFI-EUYsHVd-cPNguFH6Gjk_es-tvt__BfjllL47YHvgQem-Haesvfwq-3YHCWe8dqD-bw4htzc-25mc780f61fGyD-ze7Yd_e931a-2A-ZEPQ8QxW6_XuCaMsDh_8guAhAzf</recordid><startdate>20050802</startdate><enddate>20050802</enddate><creator>Garg, Amit X</creator><creator>Moist, Louise</creator><creator>Matsell, Douglas</creator><creator>Thiessen-Philbrook, Heather R</creator><creator>Haynes, R. Brian</creator><creator>Suri, Rita S</creator><creator>Salvadori, Marina</creator><creator>Ray, Joel</creator><creator>Clark, William F</creator><creator>for The Walkerton Health Study Investigators</creator><general>Can Med Assoc</general><general>CMA Impact Inc</general><general>CMA Impact, Inc</general><general>Canadian Medical Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISN</scope><scope>ISR</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FQ</scope><scope>8FV</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M3G</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7QL</scope><scope>7T2</scope><scope>7T7</scope><scope>7TV</scope><scope>7U1</scope><scope>7U2</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20050802</creationdate><title>Risk of hypertension and reduced kidney function after acute gastroenteritis from bacteria-contaminated drinking water</title><author>Garg, Amit X ; Moist, Louise ; Matsell, Douglas ; Thiessen-Philbrook, Heather R ; Haynes, R. Brian ; Suri, Rita S ; Salvadori, Marina ; Ray, Joel ; Clark, William F ; for The Walkerton Health Study Investigators</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c671t-4f192842ecd2d9e381926373db74d55c07df58cbbddfbad31bfc65af2ed40f8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>Campylobacter</topic><topic>Campylobacter Infections - complications</topic><topic>Causes</topic><topic>Disease Outbreaks</topic><topic>Drinking water</topic><topic>E coli</topic><topic>Escherichia coli</topic><topic>Escherichia coli Infections - complications</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastroenteritis</topic><topic>Gastroenteritis - complications</topic><topic>Gastroenteritis - epidemiology</topic><topic>Gastroenteritis - microbiology</topic><topic>Gastrointestinal diseases</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - etiology</topic><topic>Infections</topic><topic>Kidney diseases</topic><topic>Kidney Diseases - etiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Ontario - epidemiology</topic><topic>Risk Factors</topic><topic>Rural Population</topic><topic>Water Microbiology</topic><topic>Water Supply</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garg, Amit X</creatorcontrib><creatorcontrib>Moist, Louise</creatorcontrib><creatorcontrib>Matsell, Douglas</creatorcontrib><creatorcontrib>Thiessen-Philbrook, Heather R</creatorcontrib><creatorcontrib>Haynes, R. Brian</creatorcontrib><creatorcontrib>Suri, Rita S</creatorcontrib><creatorcontrib>Salvadori, Marina</creatorcontrib><creatorcontrib>Ray, Joel</creatorcontrib><creatorcontrib>Clark, William F</creatorcontrib><creatorcontrib>for The Walkerton Health Study Investigators</creatorcontrib><creatorcontrib>Walkerton Health Study Investigators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Canada</collection><collection>Gale in Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>ProQuest Nursing and Allied Health Source</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>CBCA Complete</collection><collection>Canadian Business & Current Affairs Database (Alumni Edition)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Healthcare Administration Database</collection><collection>PML(ProQuest Medical Library)</collection><collection>Psychology Database (ProQuest)</collection><collection>ProQuest_Research Library</collection><collection>ProQuest Science Journals</collection><collection>CBCA Reference & Current Events</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Pollution Abstracts</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Canadian Medical Association journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garg, Amit X</au><au>Moist, Louise</au><au>Matsell, Douglas</au><au>Thiessen-Philbrook, Heather R</au><au>Haynes, R. Brian</au><au>Suri, Rita S</au><au>Salvadori, Marina</au><au>Ray, Joel</au><au>Clark, William F</au><au>for The Walkerton Health Study Investigators</au><aucorp>Walkerton Health Study Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk of hypertension and reduced kidney function after acute gastroenteritis from bacteria-contaminated drinking water</atitle><jtitle>Canadian Medical Association journal</jtitle><addtitle>CMAJ</addtitle><date>2005-08-02</date><risdate>2005</risdate><volume>173</volume><issue>3</issue><spage>261</spage><epage>268</epage><pages>261-268</pages><issn>0008-4409</issn><issn>0820-3946</issn><eissn>1488-2329</eissn><coden>CMAJAX</coden><abstract>The long-term health consequences of acute bacterial gastroenteritis remain uncertain. We studied the risk of hypertension and reduced kidney function after an outbreak of acute gastroenteritis due to contamination of a regional drinking water supply with Escherichia coli O157:H7 and Campylobacter species.
A total of 1958 adults with no known history of hypertension or kidney disease before the outbreak participated in a long-term follow-up study. Of the participants, 675 had been asymptomatic during the outbreak, 909 had had moderate symptoms of acute self-limited gastroenteritis, and 374 had had severe symptoms that necessitated medical attention. The outcomes of interest were a diagnosis of hypertension or the presence of reduced kidney function and albuminuria during the follow-up period.
After a mean follow-up of 3.7 years after the outbreak, hypertension was diagnosed in 27.0% of participants who had been asymptomatic during the outbreak and in 32.3% and 35.9% of those who had had moderate and severe symptoms of acute gastroenteritis respectively (trend p = 0.009). Compared with the asymptomatic participants, those with moderate and severe symptoms of gastroenteritis had an adjusted relative risk of hypertension of 1.15 (95% confidence interval [CI] 0.97-1.35) and 1.28 (95% CI 1.04-1.56) respectively. A similar graded association was seen for reduced kidney function, defined as the presence of an estimated glomerular filtration rate below 60 mL/min per 1.73 m2 (trend p = 0.03). No association was observed between gastroenteritis and the subsequent risk of albuminuria.
Acute bacterial gastroenteritis necessitating medical attention was associated with an increased risk of hypertension and reduced kidney function 4 years after infection. Maintaining safe drinking water remains essential to human health, as transient bacterial contaminations may have implications well beyond a period of acute self-limited illness.</abstract><cop>Canada</cop><pub>Can Med Assoc</pub><pmid>15923490</pmid><doi>10.1503/cmaj.050581</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0008-4409 |
| ispartof | Canadian Medical Association journal, 2005-08, Vol.173 (3), p.261-268 |
| issn | 0008-4409 0820-3946 1488-2329 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1180655 |
| source | MEDLINE; PubMed Central(OpenAccess); Directory of Open Access Journals; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Acute Disease Adult Campylobacter Campylobacter Infections - complications Causes Disease Outbreaks Drinking water E coli Escherichia coli Escherichia coli Infections - complications Female Follow-Up Studies Gastroenteritis Gastroenteritis - complications Gastroenteritis - epidemiology Gastroenteritis - microbiology Gastrointestinal diseases Humans Hypertension Hypertension - etiology Infections Kidney diseases Kidney Diseases - etiology Male Middle Aged Ontario - epidemiology Risk Factors Rural Population Water Microbiology Water Supply |
| title | Risk of hypertension and reduced kidney function after acute gastroenteritis from bacteria-contaminated drinking water |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T18%3A13%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Risk%20of%20hypertension%20and%20reduced%20kidney%20function%20after%20acute%20gastroenteritis%20from%20bacteria-contaminated%20drinking%20water&rft.jtitle=Canadian%20Medical%20Association%20journal&rft.au=Garg,%20Amit%20X&rft.aucorp=Walkerton%20Health%20Study%20Investigators&rft.date=2005-08-02&rft.volume=173&rft.issue=3&rft.spage=261&rft.epage=268&rft.pages=261-268&rft.issn=0008-4409&rft.eissn=1488-2329&rft.coden=CMAJAX&rft_id=info:doi/10.1503/cmaj.050581&rft_dat=%3Cgale_pubme%3EA134673875%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=204812619&rft_id=info:pmid/15923490&rft_galeid=A134673875&rfr_iscdi=true |