Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part III: Bipolar Disorder
Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage. The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD genome scan data sets in an effort to identify regions with significant support for linkage in the combined data. The two primary ana...
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| Veröffentlicht in: | American journal of human genetics 2003-07, Vol.73 (1), p.49-62 |
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| creator | Segurado, Ricardo Detera-Wadleigh, Sevilla D. Levinson, Douglas F. Lewis, Cathryn M. Gill, Michael Nurnberger, John I. Craddock, Nick DePaulo, J. Raymond Baron, Miron Gershon, Elliot S. Ekholm, Jenny Cichon, Sven Turecki, Gustavo Claes, Stephan Kelsoe, John R. Schofield, Peter R. Badenhop, Renee F. Morissette, J. Coon, Hilary Blackwood, Douglas McInnes, L. Alison Foroud, Tatiana Edenberg, Howard J. Reich, Theodore Rice, John P. Goate, Alison McInnis, Melvin G. McMahon, Francis J. Badner, Judith A. Goldin, Lynn R. Bennett, Phil Willour, Virginia L. Zandi, Peter P. Liu, Jianjun Gilliam, Conrad Juo, Suh-Hang Berrettini, Wade H. Yoshikawa, Takeo Peltonen, Leena Lönnqvist, Jouko Nöthen, Markus M. Schumacher, Johannes Windemuth, Christine Rietschel, Marcella Propping, Peter Maier, Wolfgang Alda, Martin Grof, Paul Rouleau, Guy A. Del-Favero, Jurgen Van Broeckhoven, Christine Mendlewicz, Julien Adolfsson, Rolf Spence, M. Anne Luebbert, Hermann Adams, Linda J. Donald, Jennifer A. Mitchell, Philip B. Barden, Nicholas Shink, Eric Byerley, William Muir, Walter Visscher, Peter M. Macgregor, Stuart Gurling, Hugh Kalsi, Gursharan McQuillin, Andrew Escamilla, Michael A. Reus, Victor I. Leon, Pedro Freimer, Nelson B. Ewald, Henrik Kruse, Torben A. Mors, Ole Radhakrishna, Uppala Blouin, Jean-Louis Antonarakis, Stylianos E. Akarsu, Nurten |
| description | Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage. The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD genome scan data sets in an effort to identify regions with significant support for linkage in the combined data. The two primary analyses considered available linkage data for “very narrow” (i.e., BP-I and schizoaffective disorder–BP) and “narrow” (i.e., adding BP-II disorder) disease models, with the ranks weighted for sample size. A “broad” model (i.e., adding recurrent major depression) and unweighted analyses were also performed. No region achieved genomewide statistical significance by several simulation-based criteria. The most significant
P values ( |
| doi_str_mv | 10.1086/376547 |
| format | Article |
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Raymond ; Baron, Miron ; Gershon, Elliot S. ; Ekholm, Jenny ; Cichon, Sven ; Turecki, Gustavo ; Claes, Stephan ; Kelsoe, John R. ; Schofield, Peter R. ; Badenhop, Renee F. ; Morissette, J. ; Coon, Hilary ; Blackwood, Douglas ; McInnes, L. Alison ; Foroud, Tatiana ; Edenberg, Howard J. ; Reich, Theodore ; Rice, John P. ; Goate, Alison ; McInnis, Melvin G. ; McMahon, Francis J. ; Badner, Judith A. ; Goldin, Lynn R. ; Bennett, Phil ; Willour, Virginia L. ; Zandi, Peter P. ; Liu, Jianjun ; Gilliam, Conrad ; Juo, Suh-Hang ; Berrettini, Wade H. ; Yoshikawa, Takeo ; Peltonen, Leena ; Lönnqvist, Jouko ; Nöthen, Markus M. ; Schumacher, Johannes ; Windemuth, Christine ; Rietschel, Marcella ; Propping, Peter ; Maier, Wolfgang ; Alda, Martin ; Grof, Paul ; Rouleau, Guy A. ; Del-Favero, Jurgen ; Van Broeckhoven, Christine ; Mendlewicz, Julien ; Adolfsson, Rolf ; Spence, M. Anne ; Luebbert, Hermann ; Adams, Linda J. ; Donald, Jennifer A. ; Mitchell, Philip B. ; Barden, Nicholas ; Shink, Eric ; Byerley, William ; Muir, Walter ; Visscher, Peter M. ; Macgregor, Stuart ; Gurling, Hugh ; Kalsi, Gursharan ; McQuillin, Andrew ; Escamilla, Michael A. ; Reus, Victor I. ; Leon, Pedro ; Freimer, Nelson B. ; Ewald, Henrik ; Kruse, Torben A. ; Mors, Ole ; Radhakrishna, Uppala ; Blouin, Jean-Louis ; Antonarakis, Stylianos E. ; Akarsu, Nurten</creator><creatorcontrib>Segurado, Ricardo ; Detera-Wadleigh, Sevilla D. ; Levinson, Douglas F. ; Lewis, Cathryn M. ; Gill, Michael ; Nurnberger, John I. ; Craddock, Nick ; DePaulo, J. Raymond ; Baron, Miron ; Gershon, Elliot S. ; Ekholm, Jenny ; Cichon, Sven ; Turecki, Gustavo ; Claes, Stephan ; Kelsoe, John R. ; Schofield, Peter R. ; Badenhop, Renee F. ; Morissette, J. ; Coon, Hilary ; Blackwood, Douglas ; McInnes, L. Alison ; Foroud, Tatiana ; Edenberg, Howard J. ; Reich, Theodore ; Rice, John P. ; Goate, Alison ; McInnis, Melvin G. ; McMahon, Francis J. ; Badner, Judith A. ; Goldin, Lynn R. ; Bennett, Phil ; Willour, Virginia L. ; Zandi, Peter P. ; Liu, Jianjun ; Gilliam, Conrad ; Juo, Suh-Hang ; Berrettini, Wade H. ; Yoshikawa, Takeo ; Peltonen, Leena ; Lönnqvist, Jouko ; Nöthen, Markus M. ; Schumacher, Johannes ; Windemuth, Christine ; Rietschel, Marcella ; Propping, Peter ; Maier, Wolfgang ; Alda, Martin ; Grof, Paul ; Rouleau, Guy A. ; Del-Favero, Jurgen ; Van Broeckhoven, Christine ; Mendlewicz, Julien ; Adolfsson, Rolf ; Spence, M. Anne ; Luebbert, Hermann ; Adams, Linda J. ; Donald, Jennifer A. ; Mitchell, Philip B. ; Barden, Nicholas ; Shink, Eric ; Byerley, William ; Muir, Walter ; Visscher, Peter M. ; Macgregor, Stuart ; Gurling, Hugh ; Kalsi, Gursharan ; McQuillin, Andrew ; Escamilla, Michael A. ; Reus, Victor I. ; Leon, Pedro ; Freimer, Nelson B. ; Ewald, Henrik ; Kruse, Torben A. ; Mors, Ole ; Radhakrishna, Uppala ; Blouin, Jean-Louis ; Antonarakis, Stylianos E. ; Akarsu, Nurten</creatorcontrib><description>Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage. The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD genome scan data sets in an effort to identify regions with significant support for linkage in the combined data. The two primary analyses considered available linkage data for “very narrow” (i.e., BP-I and schizoaffective disorder–BP) and “narrow” (i.e., adding BP-II disorder) disease models, with the ranks weighted for sample size. A “broad” model (i.e., adding recurrent major depression) and unweighted analyses were also performed. No region achieved genomewide statistical significance by several simulation-based criteria. The most significant
P values (<.01) were observed on chromosomes 9p22.3-21.1 (very narrow), 10q11.21-22.1 (very narrow), and 14q24.1-32.12 (narrow). Nominally significant
P values were observed in adjacent bins on chromosomes 9p and 18p-q, across all three disease models on chromosomes 14q and 18p-q, and across two models on chromosome 8q. Relatively few BPD pedigrees have been studied under narrow disease models relative to the schizophrenia GSMA data set, which produced more significant results. There was no overlap of the highest-ranked regions for the two disorders. The present results for the very narrow model are promising but suggest that more and larger data sets are needed. Alternatively, linkage might be detected in certain populations or subsets of pedigrees. The narrow and broad data sets had considerable power, according to simulation studies, but did not produce more highly significant evidence for linkage. We note that meta-analysis can sometimes provide support for linkage but cannot disprove linkage in any candidate region.</description><identifier>ISSN: 0002-9297</identifier><identifier>EISSN: 1537-6605</identifier><identifier>DOI: 10.1086/376547</identifier><identifier>PMID: 12802785</identifier><identifier>CODEN: AJHGAG</identifier><language>eng</language><publisher>Chicago, IL: Elsevier Inc</publisher><subject>Adult and adolescent clinical studies ; Biological and medical sciences ; Bipolar Disorder - genetics ; Bipolar disorders ; Genome, Human ; Humans ; Medical sciences ; Mood disorders ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Schizophrenia - genetics</subject><ispartof>American journal of human genetics, 2003-07, Vol.73 (1), p.49-62</ispartof><rights>2003 The American Society of Human Genetics</rights><rights>2003 INIST-CNRS</rights><rights>2003 by The American Society of Human Genetics. 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Anne</creatorcontrib><creatorcontrib>Luebbert, Hermann</creatorcontrib><creatorcontrib>Adams, Linda J.</creatorcontrib><creatorcontrib>Donald, Jennifer A.</creatorcontrib><creatorcontrib>Mitchell, Philip B.</creatorcontrib><creatorcontrib>Barden, Nicholas</creatorcontrib><creatorcontrib>Shink, Eric</creatorcontrib><creatorcontrib>Byerley, William</creatorcontrib><creatorcontrib>Muir, Walter</creatorcontrib><creatorcontrib>Visscher, Peter M.</creatorcontrib><creatorcontrib>Macgregor, Stuart</creatorcontrib><creatorcontrib>Gurling, Hugh</creatorcontrib><creatorcontrib>Kalsi, Gursharan</creatorcontrib><creatorcontrib>McQuillin, Andrew</creatorcontrib><creatorcontrib>Escamilla, Michael A.</creatorcontrib><creatorcontrib>Reus, Victor I.</creatorcontrib><creatorcontrib>Leon, Pedro</creatorcontrib><creatorcontrib>Freimer, Nelson B.</creatorcontrib><creatorcontrib>Ewald, Henrik</creatorcontrib><creatorcontrib>Kruse, Torben A.</creatorcontrib><creatorcontrib>Mors, Ole</creatorcontrib><creatorcontrib>Radhakrishna, Uppala</creatorcontrib><creatorcontrib>Blouin, Jean-Louis</creatorcontrib><creatorcontrib>Antonarakis, Stylianos E.</creatorcontrib><creatorcontrib>Akarsu, Nurten</creatorcontrib><title>Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part III: Bipolar Disorder</title><title>American journal of human genetics</title><addtitle>Am J Hum Genet</addtitle><description>Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage. The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD genome scan data sets in an effort to identify regions with significant support for linkage in the combined data. The two primary analyses considered available linkage data for “very narrow” (i.e., BP-I and schizoaffective disorder–BP) and “narrow” (i.e., adding BP-II disorder) disease models, with the ranks weighted for sample size. A “broad” model (i.e., adding recurrent major depression) and unweighted analyses were also performed. No region achieved genomewide statistical significance by several simulation-based criteria. The most significant
P values (<.01) were observed on chromosomes 9p22.3-21.1 (very narrow), 10q11.21-22.1 (very narrow), and 14q24.1-32.12 (narrow). Nominally significant
P values were observed in adjacent bins on chromosomes 9p and 18p-q, across all three disease models on chromosomes 14q and 18p-q, and across two models on chromosome 8q. Relatively few BPD pedigrees have been studied under narrow disease models relative to the schizophrenia GSMA data set, which produced more significant results. There was no overlap of the highest-ranked regions for the two disorders. The present results for the very narrow model are promising but suggest that more and larger data sets are needed. Alternatively, linkage might be detected in certain populations or subsets of pedigrees. The narrow and broad data sets had considerable power, according to simulation studies, but did not produce more highly significant evidence for linkage. We note that meta-analysis can sometimes provide support for linkage but cannot disprove linkage in any candidate region.</description><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>Bipolar Disorder - genetics</subject><subject>Bipolar disorders</subject><subject>Genome, Human</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Mood disorders</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Schizophrenia - genetics</subject><issn>0002-9297</issn><issn>1537-6605</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1vEzEQxS1ERdMCfwLaC5y64I_1FwekUqCNVAQScOJgTexZYrSxg72p1P71bJSIlnLgNNK8n948zSPkKaMvGTXqldBKdvoBmTEpdKsUlQ_JjFLKW8utPiRHtf6klDFDxSNyyLihXBs5I9_PMeUVNl88pOYjjtCeJhiua6xN7qftMt7k9bJgitBACs3buM4DlOZdrLkELCfNZyhjM5_PX_-jPSYHPQwVn-znMfn24f3Xs4v28tP5_Oz0svVS0LENEDh6LhkosH2vpNVeGWE7qTntUaFcUO87awK1YWFskDIoYylIHYLpOnFM3ux815vFCoPHNBYY3LrEFZRrlyG6v5UUl-5HvnLbd0hjJ4MXe4OSf22wjm4Vq8dhgIR5U50WQmspxX9BZgzXkt9x9CXXWrD_k4ZRty3M7QqbwGd3s99i-4Ym4PkegOph6AskH-st11mpjd1epDsOp09fRSyu-ojJY4gF_ehCjvdv_waYeazd</recordid><startdate>20030701</startdate><enddate>20030701</enddate><creator>Segurado, Ricardo</creator><creator>Detera-Wadleigh, Sevilla D.</creator><creator>Levinson, Douglas F.</creator><creator>Lewis, Cathryn M.</creator><creator>Gill, Michael</creator><creator>Nurnberger, John I.</creator><creator>Craddock, Nick</creator><creator>DePaulo, J. 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Raymond ; Baron, Miron ; Gershon, Elliot S. ; Ekholm, Jenny ; Cichon, Sven ; Turecki, Gustavo ; Claes, Stephan ; Kelsoe, John R. ; Schofield, Peter R. ; Badenhop, Renee F. ; Morissette, J. ; Coon, Hilary ; Blackwood, Douglas ; McInnes, L. Alison ; Foroud, Tatiana ; Edenberg, Howard J. ; Reich, Theodore ; Rice, John P. ; Goate, Alison ; McInnis, Melvin G. ; McMahon, Francis J. ; Badner, Judith A. ; Goldin, Lynn R. ; Bennett, Phil ; Willour, Virginia L. ; Zandi, Peter P. ; Liu, Jianjun ; Gilliam, Conrad ; Juo, Suh-Hang ; Berrettini, Wade H. ; Yoshikawa, Takeo ; Peltonen, Leena ; Lönnqvist, Jouko ; Nöthen, Markus M. ; Schumacher, Johannes ; Windemuth, Christine ; Rietschel, Marcella ; Propping, Peter ; Maier, Wolfgang ; Alda, Martin ; Grof, Paul ; Rouleau, Guy A. ; Del-Favero, Jurgen ; Van Broeckhoven, Christine ; Mendlewicz, Julien ; Adolfsson, Rolf ; Spence, M. Anne ; Luebbert, Hermann ; Adams, Linda J. ; Donald, Jennifer A. ; Mitchell, Philip B. ; Barden, Nicholas ; Shink, Eric ; Byerley, William ; Muir, Walter ; Visscher, Peter M. ; Macgregor, Stuart ; Gurling, Hugh ; Kalsi, Gursharan ; McQuillin, Andrew ; Escamilla, Michael A. ; Reus, Victor I. ; Leon, Pedro ; Freimer, Nelson B. ; Ewald, Henrik ; Kruse, Torben A. ; Mors, Ole ; Radhakrishna, Uppala ; Blouin, Jean-Louis ; Antonarakis, Stylianos E. ; Akarsu, Nurten</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c530t-dad2ec251a6a9ff6597c683945720fe6e5b0cc498d09db89d55d6890a57dd8443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Biological and medical sciences</topic><topic>Bipolar Disorder - genetics</topic><topic>Bipolar disorders</topic><topic>Genome, Human</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Mood disorders</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Schizophrenia - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Segurado, Ricardo</creatorcontrib><creatorcontrib>Detera-Wadleigh, Sevilla D.</creatorcontrib><creatorcontrib>Levinson, Douglas F.</creatorcontrib><creatorcontrib>Lewis, Cathryn M.</creatorcontrib><creatorcontrib>Gill, Michael</creatorcontrib><creatorcontrib>Nurnberger, John I.</creatorcontrib><creatorcontrib>Craddock, Nick</creatorcontrib><creatorcontrib>DePaulo, J. Raymond</creatorcontrib><creatorcontrib>Baron, Miron</creatorcontrib><creatorcontrib>Gershon, Elliot S.</creatorcontrib><creatorcontrib>Ekholm, Jenny</creatorcontrib><creatorcontrib>Cichon, Sven</creatorcontrib><creatorcontrib>Turecki, Gustavo</creatorcontrib><creatorcontrib>Claes, Stephan</creatorcontrib><creatorcontrib>Kelsoe, John R.</creatorcontrib><creatorcontrib>Schofield, Peter R.</creatorcontrib><creatorcontrib>Badenhop, Renee F.</creatorcontrib><creatorcontrib>Morissette, J.</creatorcontrib><creatorcontrib>Coon, Hilary</creatorcontrib><creatorcontrib>Blackwood, Douglas</creatorcontrib><creatorcontrib>McInnes, L. Alison</creatorcontrib><creatorcontrib>Foroud, Tatiana</creatorcontrib><creatorcontrib>Edenberg, Howard J.</creatorcontrib><creatorcontrib>Reich, Theodore</creatorcontrib><creatorcontrib>Rice, John P.</creatorcontrib><creatorcontrib>Goate, Alison</creatorcontrib><creatorcontrib>McInnis, Melvin G.</creatorcontrib><creatorcontrib>McMahon, Francis J.</creatorcontrib><creatorcontrib>Badner, Judith A.</creatorcontrib><creatorcontrib>Goldin, Lynn R.</creatorcontrib><creatorcontrib>Bennett, Phil</creatorcontrib><creatorcontrib>Willour, Virginia L.</creatorcontrib><creatorcontrib>Zandi, Peter P.</creatorcontrib><creatorcontrib>Liu, Jianjun</creatorcontrib><creatorcontrib>Gilliam, Conrad</creatorcontrib><creatorcontrib>Juo, Suh-Hang</creatorcontrib><creatorcontrib>Berrettini, Wade H.</creatorcontrib><creatorcontrib>Yoshikawa, Takeo</creatorcontrib><creatorcontrib>Peltonen, Leena</creatorcontrib><creatorcontrib>Lönnqvist, Jouko</creatorcontrib><creatorcontrib>Nöthen, Markus M.</creatorcontrib><creatorcontrib>Schumacher, Johannes</creatorcontrib><creatorcontrib>Windemuth, Christine</creatorcontrib><creatorcontrib>Rietschel, Marcella</creatorcontrib><creatorcontrib>Propping, Peter</creatorcontrib><creatorcontrib>Maier, Wolfgang</creatorcontrib><creatorcontrib>Alda, Martin</creatorcontrib><creatorcontrib>Grof, Paul</creatorcontrib><creatorcontrib>Rouleau, Guy A.</creatorcontrib><creatorcontrib>Del-Favero, Jurgen</creatorcontrib><creatorcontrib>Van Broeckhoven, Christine</creatorcontrib><creatorcontrib>Mendlewicz, Julien</creatorcontrib><creatorcontrib>Adolfsson, Rolf</creatorcontrib><creatorcontrib>Spence, M. Anne</creatorcontrib><creatorcontrib>Luebbert, Hermann</creatorcontrib><creatorcontrib>Adams, Linda J.</creatorcontrib><creatorcontrib>Donald, Jennifer A.</creatorcontrib><creatorcontrib>Mitchell, Philip B.</creatorcontrib><creatorcontrib>Barden, Nicholas</creatorcontrib><creatorcontrib>Shink, Eric</creatorcontrib><creatorcontrib>Byerley, William</creatorcontrib><creatorcontrib>Muir, Walter</creatorcontrib><creatorcontrib>Visscher, Peter M.</creatorcontrib><creatorcontrib>Macgregor, Stuart</creatorcontrib><creatorcontrib>Gurling, Hugh</creatorcontrib><creatorcontrib>Kalsi, Gursharan</creatorcontrib><creatorcontrib>McQuillin, Andrew</creatorcontrib><creatorcontrib>Escamilla, Michael A.</creatorcontrib><creatorcontrib>Reus, Victor I.</creatorcontrib><creatorcontrib>Leon, Pedro</creatorcontrib><creatorcontrib>Freimer, Nelson B.</creatorcontrib><creatorcontrib>Ewald, Henrik</creatorcontrib><creatorcontrib>Kruse, Torben A.</creatorcontrib><creatorcontrib>Mors, Ole</creatorcontrib><creatorcontrib>Radhakrishna, Uppala</creatorcontrib><creatorcontrib>Blouin, Jean-Louis</creatorcontrib><creatorcontrib>Antonarakis, Stylianos E.</creatorcontrib><creatorcontrib>Akarsu, Nurten</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of human genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Segurado, Ricardo</au><au>Detera-Wadleigh, Sevilla D.</au><au>Levinson, Douglas F.</au><au>Lewis, Cathryn M.</au><au>Gill, Michael</au><au>Nurnberger, John I.</au><au>Craddock, Nick</au><au>DePaulo, J. Raymond</au><au>Baron, Miron</au><au>Gershon, Elliot S.</au><au>Ekholm, Jenny</au><au>Cichon, Sven</au><au>Turecki, Gustavo</au><au>Claes, Stephan</au><au>Kelsoe, John R.</au><au>Schofield, Peter R.</au><au>Badenhop, Renee F.</au><au>Morissette, J.</au><au>Coon, Hilary</au><au>Blackwood, Douglas</au><au>McInnes, L. Alison</au><au>Foroud, Tatiana</au><au>Edenberg, Howard J.</au><au>Reich, Theodore</au><au>Rice, John P.</au><au>Goate, Alison</au><au>McInnis, Melvin G.</au><au>McMahon, Francis J.</au><au>Badner, Judith A.</au><au>Goldin, Lynn R.</au><au>Bennett, Phil</au><au>Willour, Virginia L.</au><au>Zandi, Peter P.</au><au>Liu, Jianjun</au><au>Gilliam, Conrad</au><au>Juo, Suh-Hang</au><au>Berrettini, Wade H.</au><au>Yoshikawa, Takeo</au><au>Peltonen, Leena</au><au>Lönnqvist, Jouko</au><au>Nöthen, Markus M.</au><au>Schumacher, Johannes</au><au>Windemuth, Christine</au><au>Rietschel, Marcella</au><au>Propping, Peter</au><au>Maier, Wolfgang</au><au>Alda, Martin</au><au>Grof, Paul</au><au>Rouleau, Guy A.</au><au>Del-Favero, Jurgen</au><au>Van Broeckhoven, Christine</au><au>Mendlewicz, Julien</au><au>Adolfsson, Rolf</au><au>Spence, M. Anne</au><au>Luebbert, Hermann</au><au>Adams, Linda J.</au><au>Donald, Jennifer A.</au><au>Mitchell, Philip B.</au><au>Barden, Nicholas</au><au>Shink, Eric</au><au>Byerley, William</au><au>Muir, Walter</au><au>Visscher, Peter M.</au><au>Macgregor, Stuart</au><au>Gurling, Hugh</au><au>Kalsi, Gursharan</au><au>McQuillin, Andrew</au><au>Escamilla, Michael A.</au><au>Reus, Victor I.</au><au>Leon, Pedro</au><au>Freimer, Nelson B.</au><au>Ewald, Henrik</au><au>Kruse, Torben A.</au><au>Mors, Ole</au><au>Radhakrishna, Uppala</au><au>Blouin, Jean-Louis</au><au>Antonarakis, Stylianos E.</au><au>Akarsu, Nurten</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part III: Bipolar Disorder</atitle><jtitle>American journal of human genetics</jtitle><addtitle>Am J Hum Genet</addtitle><date>2003-07-01</date><risdate>2003</risdate><volume>73</volume><issue>1</issue><spage>49</spage><epage>62</epage><pages>49-62</pages><issn>0002-9297</issn><eissn>1537-6605</eissn><coden>AJHGAG</coden><abstract>Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage. The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD genome scan data sets in an effort to identify regions with significant support for linkage in the combined data. The two primary analyses considered available linkage data for “very narrow” (i.e., BP-I and schizoaffective disorder–BP) and “narrow” (i.e., adding BP-II disorder) disease models, with the ranks weighted for sample size. A “broad” model (i.e., adding recurrent major depression) and unweighted analyses were also performed. No region achieved genomewide statistical significance by several simulation-based criteria. The most significant
P values (<.01) were observed on chromosomes 9p22.3-21.1 (very narrow), 10q11.21-22.1 (very narrow), and 14q24.1-32.12 (narrow). Nominally significant
P values were observed in adjacent bins on chromosomes 9p and 18p-q, across all three disease models on chromosomes 14q and 18p-q, and across two models on chromosome 8q. Relatively few BPD pedigrees have been studied under narrow disease models relative to the schizophrenia GSMA data set, which produced more significant results. There was no overlap of the highest-ranked regions for the two disorders. The present results for the very narrow model are promising but suggest that more and larger data sets are needed. Alternatively, linkage might be detected in certain populations or subsets of pedigrees. The narrow and broad data sets had considerable power, according to simulation studies, but did not produce more highly significant evidence for linkage. We note that meta-analysis can sometimes provide support for linkage but cannot disprove linkage in any candidate region.</abstract><cop>Chicago, IL</cop><pub>Elsevier Inc</pub><pmid>12802785</pmid><doi>10.1086/376547</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9297 |
| ispartof | American journal of human genetics, 2003-07, Vol.73 (1), p.49-62 |
| issn | 0002-9297 1537-6605 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1180589 |
| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adult and adolescent clinical studies Biological and medical sciences Bipolar Disorder - genetics Bipolar disorders Genome, Human Humans Medical sciences Mood disorders Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Schizophrenia - genetics |
| title | Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part III: Bipolar Disorder |
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